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Solid-Phase Synthesis of CD40L Mimetics [PDF]

Synfacts, 2006
The C3-symmetric molecule has been previously shown to mimic CD40 ligand (CD40L) homotrimers and to display effector functions. This molecule consists of a cyclic hexapeptide core containing the repetition of the D-Ala-L-Lys motif. The side chains of the lysine residues have been modified by appending the CD40L-derived sequence 143Lys-Gly-Tyr-Tyr146 ...
Sylvie Fournel, Johan Hoebeke, Alberto Bianco, Sébastien Wieckowski, Gilles Guichard   +4 more
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Solid‐phase synthesis of H‐ and methylphosphonopeptides

International Journal of Peptide and Protein Research, 1996
We introduce solid‐phase syntheses of H‐ and methylphosphonopeptides, giving access for the first time to a new class of mimics for o‐phosphoamino acids. The model peptides H‐GlyGlyXaaAla‐OH (Xaa = Ser, Thr) were synthesized on a solid‐phase using Fmoc/tBu strategy and HBTU/HOBt activation by incorporation of hydroxyl‐protected serine and threonine. As
Hoffmann, R., Tholey, A., Hoffmann, T., Kalbitzer, H.   +3 more
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Solid-phase dendrimer synthesis

Biopolymers, 1998
Dendrimers are highly ordered, hyperbranched polymers with potential for a whole range of chemical applications. Solution-phase synthesis of dendrimers is often challenging, requiring long reaction times and nontrivial purification; solid-phase methodology, on the other hand, enables reactions to be driven to completion by using a large excess of ...
N. WELLS, BASSO, ANDREA, M. BRADLEY
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Solid-Phase Organometallic Synthesis

Chemistry - A European Journal, 2001
A solid-phase synthesis approach for a class of molybdenum carbonyl complexes has been developed. The system can be used to perform metal-complexation, ligand substitution reactions and oxidative eliminations on the solid phase and to cleave the final complexes under mild and selective conditions.
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Lanthanide Reagents in Solid Phase Synthesis

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sloan, Lisa A., Procter, David J.
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Solid-phase phosphatidylethanolamine synthesis

Reactive Polymers, 1989
Abstract Dipalmitoylphosphatidylethanolamine(DPPE) was prepared from natural phosphatidylethanolamine (cephalin) and palmitic anhydride (PAh) by using polymer-supported trityl as a protective group for the ammo group of cephalin.
M. Tomoi, Y. Kimura, S. Tokuyama
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Solid-Phase Peptide Synthesis

Endeavour, 1965
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Solid-Phase Synthesis of Fullerene-peptides

Journal of the American Chemical Society, 2002
The solid-phase synthesis of peptides (SPPS) containing [60]fullerene-functionalized amino acids is reported. A new amino acid, fulleropyrrolidino-glutamic acid (Fgu), is used for the SPPS of a series of analogues of different length based on the natural Leu(5)-Enkephalin and on cationic antimicrobial peptides.
PANTAROTTO, DAVIDE, BIANCO A, PELLARINI F, TOSSI, ALESSANDRO, GIANGASPERO, ANNA, ZELEZETSKY, IGOR, BRIAND JP, PRATO, MAURIZIO   +7 more
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Solid‐phase peptide synthesis on proteins

International Journal of Peptide and Protein Research, 1993
A new method for solid‐phase peptide synthesis in which a protein is used as the solid support has been developed. Two aspects of the method have been demonstrated. The peptides H‐Phe‐Leu‐Glu‐Glu‐Val‐OH (1) and H‐Leu‐Leu‐Ala‐Glj‐Val‐OH (2), respectively, were synthesized on the amino groups of BSA via a cleaveable linker, using the Fmoc group ...
Hansen, Paul Robert, Holm, Arne, Houen, Gunnar   +2 more
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Fmoc Solid-Phase Peptide Synthesis

2015
Synthetic peptides are important as drugs and in research. Currently, the method of choice for producing these compounds is solid-phase peptide synthesis. In this nonspecialist review, we describe the scope and limitations of Fmoc solid-phase peptide synthesis. Furthermore, we provide a detailed protocol for Fmoc peptide synthesis.
Hansen, Paul Robert, Oddo, Alberto
openaire   +4 more sources