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Need for Solid-Phase Thinking in Solid-Phase Synthesis
1973The invention of the solid-phase method looked like an ingenious trick to overcome some of the unpleasant features of the classical methods. As we know today, the ingenuity of the trick remains, but only a large investment of heavy real effort will eventually, if ever, work it into a real progress over the classical approach.
P. Fankhauser, M. Brenner
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[48] Solid-phase peptide synthesis
1977Publisher Summary In solid-phase peptide synthesis, protein is synthesized by the successive addition of appropriately protected amino acid residues to a completely insoluble growing point. The majority of peptides prepared by solid-phase techniques have been synthesized in a stepwise fashion with progression from the COOH-terminal to the NH 2 ...
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Solid-Phase Synthesis of Octapeptin Lipopeptides
2019Octapeptins are naturally derived cyclic lipopeptide antibiotics with activity against a range of Gram-negative pathogens, including highly resistant strains. Octapeptin C4, an exemplar of the class, was synthesized using a combination of Fmoc solid-phase peptide synthesis (SPPS) and solution-phase cyclization.
Hansford, Karl A. +3 more
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1991
This chapter discusses solid phase peptide synthesis, an idea which first appeared in a scientific publication by Merrifield in 1963. It explains why the term ‘solid phaseȉ is misleading, elaborating that the reactions do not take place in or on the surfaces of solid phases, but in gel systems produced by the penetration of solvent and solute molecules
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This chapter discusses solid phase peptide synthesis, an idea which first appeared in a scientific publication by Merrifield in 1963. It explains why the term ‘solid phaseȉ is misleading, elaborating that the reactions do not take place in or on the surfaces of solid phases, but in gel systems produced by the penetration of solvent and solute molecules
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1988
By the conventional methods of organic synthesis, preparation of peptides containing more than just a few amino acids is an arduous task. Introduction of blocking groups, coupling reactions and deprotection steps entail a large number of operations, such as washing the reaction mixtures neutral after coupling, precipitation or crystallization of ...
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By the conventional methods of organic synthesis, preparation of peptides containing more than just a few amino acids is an arduous task. Introduction of blocking groups, coupling reactions and deprotection steps entail a large number of operations, such as washing the reaction mixtures neutral after coupling, precipitation or crystallization of ...
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Solid phase synthesis of oxytocin
Tetrahedron Letters, 1968Hanspaul Hagenmaier, Ernst Bayer
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SERS and Solid Phase Synthesis
AIP Conference Proceedings, 2010Magdalena Gellner +5 more
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Solid Phase Synthesis of Thiomethylene Pseudopeptides
2002FIERRO, OLGA +2 more
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