Results 31 to 40 of about 1,773,765 (367)
Solid‐Phase Supports for Oligonucleotide Synthesis [PDF]
Current Protocols in Nucleic Acid Chemistry, 2000 AbstractThis unit begins with a discussion of the advantages and disadvantages of oligonucleotide synthesis using solid supports. The physical and chemical properties of solid‐phase supports are discussed in terms of their suitability for oligonucleotide synthesis. In addition, the unit outlines the properties of linkers used for transient or permanent
Richard T. Pon
openalex +7 more sources
Total wash elimination for solid phase peptide synthesis
Nature Communications, 2023 We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins +6 more
doaj +1 more source
HOBt·DCHA-Mediated Synthesis of Sterically Hindered Peptides employing Fmoc-Amino Acid Chlorides in Both Solution-Phase and Solid Phase Methods [PDF]
, 2008 The synthesis of peptides employing Fmoc-amino acid chlorides in presence of HOBt·DCHA salt in solution as well as by the solid-phase methods is described. The coupling was found to be complete in 30 min and free from racemization.
Krishna, G.C. +2 more
core +1 more source
Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis
Green Chemistry Letters and Reviews, 2021 PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives.
Ashish Kumar +3 more
doaj +1 more source
A microfluidic oligonucleotide synthesizer [PDF]
, 2010 De novo gene and genome synthesis enables the design of any sequence without the requirement of a pre-existing template as in traditional genetic engineering methods.
Lee, Cheng-Chung +2 more
core +4 more sources
Molecules, 2011 The solid-phase synthesis of the first example of a new diphosphate AICAR derivative is reported. The new substance is characterized by the presence of a 5'-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached ...
Gennaro Piccialli +7 more
doaj +1 more source
An overview of recent progress in modern synthetic approach—combinatorial synthesis
Beni-Suef University Journal of Basic and Applied Sciences, 2020 Background In recent times, a powerful tool of combinatorial synthesis has been used for the preparation of large chemical entities through a small set up of reactions between different building blocks using solid-phase and solution-phase techniques ...
Chandravadivelu Gopi +3 more
doaj +1 more source
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication.
Organic Letters, 2019 We investigated the ultrasonication-mediated effects on the Fmoc-based solid-phase peptide synthesis (SPPS). Our study culminated with the development of an ultrasound-assisted strategy (US-SPPS) that allowed for the synthesis of different biologically ...
F. Merlino +8 more
semanticscholar +1 more source
ACS Sustainable Chemistry and Engineering, 2019 To replace dimethylformamide (DMF) in fluorenylmethoxycarbonyl (Fmoc) solid-phase peptide synthesis, we explored the application of mixtures of green solvents (green solvents mixtures for solid-phase peptide synthesis (GM-SPPS)) as combinations of Cyrene
L. Ferrazzano +6 more
semanticscholar +1 more source
New Solid Phase Synthesis of Distamycin Analogues
Molecules, 2011 A novel and straightforward solid phase synthesis of distamycin analogues containing benzene units has been developed.
Drozdowska Danuta
doaj +1 more source