Results 31 to 40 of about 1,857,199 (369)

Green Solvent Mixtures for Solid-Phase Peptide Synthesis: A Dimethylformamide-Free Highly Efficient Synthesis of Pharmaceutical-Grade Peptides

ACS Sustainable Chemistry and Engineering, 2019
To replace dimethylformamide (DMF) in fluorenylmethoxycarbonyl (Fmoc) solid-phase peptide synthesis, we explored the application of mixtures of green solvents (green solvents mixtures for solid-phase peptide synthesis (GM-SPPS)) as combinations of Cyrene
L. Ferrazzano, Dario Corbisiero, Giulia Martelli, A. Tolomelli, Angelo Viola, Antonio Ricci, W. Cabri   +6 more
semanticscholar   +1 more source

HOBt·DCHA-Mediated Synthesis of Sterically Hindered Peptides employing Fmoc-Amino Acid Chlorides in Both Solution-Phase and Solid Phase Methods [PDF]

, 2008
The synthesis of peptides employing Fmoc-amino acid chlorides in presence of HOBt·DCHA salt in solution as well as by the solid-phase methods is described. The coupling was found to be complete in 30 min and free from racemization.
Krishna, G.C., Sudarshan, N.S., Sureshbabu, V.V.   +2 more
core   +1 more source

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose

Molecules, 2011
The solid-phase synthesis of the first example of a new diphosphate AICAR derivative is reported. The new substance is characterized by the presence of a 5'-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached ...
Gennaro Piccialli, Vincenzo Piccialli, Luciano Mayol, Michela Varra, Jussara Amato, Nicola Borbone, Giorgia Oliviero, Stefano D’Errico   +7 more
doaj   +1 more source

Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication.

Organic Letters, 2019
We investigated the ultrasonication-mediated effects on the Fmoc-based solid-phase peptide synthesis (SPPS). Our study culminated with the development of an ultrasound-assisted strategy (US-SPPS) that allowed for the synthesis of different biologically ...
F. Merlino, Stefano Tomassi, A. M. Yousif, A. Messere, L. Marinelli, P. Grieco, E. Novellino, S. Cosconati, Salvatore Di Maro   +8 more
semanticscholar   +1 more source

Parallel solid-phase synthesis of diaryltriazoles

Beilstein Journal of Organic Chemistry, 2012
A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a ...
Matthias Wrobel, Jeffrey Aubé, Burkhard König   +2 more
doaj   +1 more source

New Solid Phase Synthesis of Distamycin Analogues

Molecules, 2011
A novel and straightforward solid phase synthesis of distamycin analogues containing benzene units has been developed.
Drozdowska Danuta
doaj   +1 more source

Optimized Solid Phase-Assisted Synthesis of Dendrons Applicable as Scaffolds for Radiolabeled Bioactive Multivalent Compounds Intended for Molecular Imaging

Molecules, 2014
Dendritic structures, being highly homogeneous and symmetric, represent ideal scaffolds for the multimerization of bioactive molecules and thus enable the synthesis of compounds of high valency which are e.g., applicable in radiolabeled form as ...
Gabriel Fischer, Björn Wängler, Carmen Wängler   +2 more
doaj   +1 more source

An overview of recent progress in modern synthetic approach—combinatorial synthesis

Beni-Suef University Journal of Basic and Applied Sciences, 2020
Background In recent times, a powerful tool of combinatorial synthesis has been used for the preparation of large chemical entities through a small set up of reactions between different building blocks using solid-phase and solution-phase techniques ...
Chandravadivelu Gopi, Gudapati Krupamai, Chitikina Satya Sri, Magharla Dasaratha Dhanaraju   +3 more
doaj   +1 more source

Novel sulfur and selenium containing bis-α-amino acids from 4-hydroxyproline [PDF]

, 2010
The synthesis of new substituted prolines carrying at C-4 a second α-amino acid residue is reported. The amino acid, l-cysteine or l-selenocysteine, is linked to the proline ring through the sulfur or the selenium atom, respectively.
CAPUTO, ROMUALDO, D. MASTROIANNI, DELLA GRECA, MARINA, I. de PAOLA, LONGOBARDO, LUIGI   +4 more
core   +1 more source

Solid-Phase Synthesis of ?-Oligopeptides

CHIMIA, 1997
Fmoc-N-Protected ?-amino acids of (S)-configuration bearing the side chains of Ala, Val, Leu, and Phe in the 3- and 2-position have been prepared. Manual solid-phase synthesis (ortho-chlorotrityl-chloride resin) of the ?-heptapeptides H-?3-HVal-?
Gilles Guichard, Dieter Seebach
doaj   +2 more sources