Results 91 to 100 of about 22,095 (155)

SOLID DISPERSION: STRATEGY TO ENHANCE SOLUBILITY

, 2015
The solubility behavior of drugs remains one of the most exigent aspects in formulation development.With the advent of combinatorial chemistry and high throughput screening, the number of poorly water soluble compounds has dramatically increased.  Among
INGALE, P R, Gerange, A B, Dalvi, P B
core   +1 more source

Dissolution Enhancement and Characterization of Nimodipine Solid Dispersions with Poloxamer 407 or PEG 6000

, 2012
The solid dispersion approach is an alternative to increase drug solubility. Many carriers have been studied, but there is few information about poloxamer 407 (P407).
Kaneko, T. M., Baby, A. R., Serra, C. H. R., Velasco, M. V. R., Duque, M. D., Kreidel, R. N., Consiglieri, V. O.   +6 more
core   +1 more source

Novel nanocrystal-based solid dispersion with high drug loading, enhanced dissolution, and bioavailability of andrographolide

, 2018
Yueqin Ma,1,2,* Yang Yang,2,* Jin Xie,1 Junnan Xu,1 Pengfei Yue,1 Ming Yang1 1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, 2Department of Medicine and ...
Yang Y, Yue P, Xie J, Yang M, Ma Y, Xu J
core  

Nimodipino: do polimorfismo à obtenção de dispersões sólidas amorfas destinadas ao tratamento da hipertensão arterial [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.A baixa solubilidade de fármacos apresenta-se como um dos aspectos mais desafiadores no ...
Riekes, Manoela Klüppel
core  

Mid-IR coherent supercontinuum generation in all-solid step-index soft glass fibers

We numerically demonstrate that normal dispersion femtosecond pumping of tailored soft glass step-index fibers can generate highly coherent mid-IR supercontinuum light with two octaves bandwidth, suitable for recompression to few-cycle pulse ...
Heidt, A.M., Price, J.H.V., Richardson, D.J., Poletti, F.   +3 more
core  

Novel methotrexate long-acting system using ambroxol coating and hydroxypropyl methylcellulose encapsulation for preferential and enhanced lung cancer efficiency.

PLoS ONE
Methotrexate (MTX) is classified as an antimetabolite. It's commonly used to treat lung cancer. MTX is an immunosuppressant following the above-mentioned mechanism of action due to its poor selectivity.
Samaa Abdullah, Najla Altwaijry, Meaad Alnakhli, Ghezlan ALenezi, Alaa A Al-Masud, Hanan Henidi, Yahya F Jamous   +6 more
doaj   +1 more source

GAS HOLDUP AND AXIAL LIQUID DISPERSION IN THREE PHASE BUBBLE COLUMNS

Journal of Engineering and Sustainable Development, 2015
Axial liquid dispersion coefficient was studied in air-tap water systems (bubble columns) and air-tap water-PVC solid particles systems for different column diameters, 10, 15, and 30 cm, Each column had a gas distributor plate with perforated holes of
Burhan Sadeq Abdulrazzaq
doaj  

A REVIEW: SOLID DISPERSION

, 2014
Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Solid dispersions of poorly water-soluble drugs with water-soluble carriers has reduced the incidence of these problems and enhanced dissolution.
openaire   +2 more sources

The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: impact on solubility

, 2012
Kerstin J Frank,1,3 Ulrich Westedt,2 Karin M Rosenblatt,2 Peter Hölig,2 Jörg Rosenberg,2 Markus Mägerlein,2 Gert Fricker,3 Martin Brandl11Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense ...
Frank KJ, Hölig P, Rosenblatt KM, Fricker G, Brandl M, Mägerlein M, Rosenberg J, Westedt U   +7 more
core  

Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process

, 2011
Min-Soo Kim1, Jeong-Soo Kim1, Hee Jun Park1, Won Kyung Cho1,3, Kwang-Ho Cha1,3, Sung-Joo Hwang2,31College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea, 2College of Pharmacy, 3Yonsei Institute of Pharmaceutical Sciences, Yonsei ...
Hwang SJ, Kim MS, Park HJ, Cho WK, Cha KH, Kim JS   +5 more
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