Results 81 to 90 of about 784,608 (295)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Use of Solid Dispersion Systems in Pharmacy
Конденсированные среды и межфазные границы, 2020 An overview of the use of solid dispersion systems in pharmacy is presented. The main techniques of obtaining solid dispersions were considered. The simplest one is the solvent removal technique: the medicinal drug and the carrier are dissolved in the ...
Sof ’ya Yu. Silaeva +6 more
doaj +1 more source
Drug Design, Development and Therapy, 2015 Eun-Sol Ha,1 Jeong-Soo Kim,2 In-hwan Baek,3 Jin-Wook Yoo,1 Yunjin Jung,1 Hyung Ryong Moon,1 Min-Soo Kim1 1College of Pharmacy, Pusan National University, 2Dong-A ST Co Ltd, Yongin, 3College of Pharmacy, Kyungsung University, Busan, South Korea Abstract:
Ha ES +6 more
doaj
International Journal of Nanomedicine, 2023 Junying Zhang,1,* Yiwen Zhang,1,* Hufang Wang,1 Wenlin Chen,1 Aiyu Lu,1 Hailiang Li,1 Lifeng Kang,2 Chunyong Wu3 1Department of TCMs Pharmaceuticals, China Pharmaceutical University, Nanjing, People’s Republic of China; 2School of Pharmacy, Faculty
Zhang J +7 more
doaj
Pharmaceutics, 2018 Over the past decades, a large number of drugs as well as drug candidates with poor dissolution characteristics have been witnessed, which invokes great interest in enabling formulation of these active ingredients.
Xingwang Zhang +3 more
doaj +1 more source
Disolusi Asam Mefenamat Dalam Sistem Dispersi Padat Dengan Peg 4000 [PDF]
, 2014 Mefenamic acid is an analgetic that insoluble in water and classified into class II in theBiopharmaceutic Classification System (BCS), therefore the dissolution become the rate limitingstep of absorption process and bioavailability.
Sugiyono, S. (Sugiyono) +2 more
core
Pattern formation in crystal growth under parabolic shear flow
, 2003 Morphological instability of the solid-liquid interface occuring in a crystal growing from an undercooled thin liquid being bounded on one side by a free surface and flowing down inclined plane is investigated by a linear stability analysis under shear ...
A. Betat +9 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Asian Journal of Pharmaceutical Sciences, 2018 Due to low solubility and bioavailability, atorvastatin calcium is confronted with challenge in conceiving appropriate formulation. Solid dispersion of atorvastatin calcium was prepared through the solvent evaporation method, with Poloxamer 188 as ...
Wenxiang Dong +5 more
doaj +1 more source