Results 61 to 70 of about 22,095 (155)

Analysis of some B-adrenergic agonists in biological matrices after evaluation of various extraction methodologies and determination procedures [PDF]

, 1994
Biological sample clean-up procedures were evaluated for the extraction of a range of /3-agonists. Once extracted the compounds were determined by immunoassay, electrochemical techniques and supercritical fluid chromatography (SFC).
Boyd, Damien Thomas
core  

A REVIEW ON SOLID DISPERSION CONTAINING PHOSPHOLIPID

, 2019
The oral solubility of poorly aqueous soluble drugs endures the major challenging feature in pharmaceutical formulation. There are more than 60-70 % of the drugs suffers low aqueous solubility, which can be dramatically increased by solid dispersion. One
Osama R. Ahmed, Vishal C. Gurumukhi*, Shailesh S. Chalikwar
core   +1 more source

Solid-Phase Debundling of Single-Walled Carbon Nanotubes for the “Stock Solid” Delivery of Concentrated Nanotube Dispersions

, 2019
Debundling of single-walled carbon nanotubes (SWNTs) has been mostly limited to liquid-phase exfoliation. Since the SWNTs in dispersion are prone to aggregate and precipitate gradually during their storage, a solid-phase method that provides debundled ...
Wubin Dai (1503829), Shunjie Wang (6388688), Ping Zhao (47228), Gang Liu (81776), Xueying Zeng (4354027), Neng Liu (2118667), Can Qin (6388685), Shengwei Shi (3226881)   +7 more
core   +2 more sources

Solubilisation and Enhanced Oral Absorption of Curcumin Using a Natural Non-Nutritive Sweetener Mogroside V

International Journal of Nanomedicine, 2023
Junying Zhang,1,* Yiwen Zhang,1,* Hufang Wang,1 Wenlin Chen,1 Aiyu Lu,1 Hailiang Li,1 Lifeng Kang,2 Chunyong Wu3 1Department of TCMs Pharmaceuticals, China Pharmaceutical University, Nanjing, People’s Republic of China; 2School of Pharmacy, Faculty
Zhang J, Zhang Y, Wang H, Chen W, Lu A, Li H, Kang L, Wu C   +7 more
doaj  

Preparation, characterization, and in vitro/vivo evaluation of polymer-assisting formulation of atorvastatin calcium based on solid dispersion technique

Asian Journal of Pharmaceutical Sciences, 2018
Due to low solubility and bioavailability, atorvastatin calcium is confronted with challenge in conceiving appropriate formulation. Solid dispersion of atorvastatin calcium was prepared through the solvent evaporation method, with Poloxamer 188 as ...
Wenxiang Dong, Xitong Su, Meng Xu, Mingming Hu, Yinghua Sun, Peng Zhang   +5 more
doaj   +1 more source

Itraconazole solid dispersion prepared by a supercritical fluid technique: preparation, in vitro characterization, and bioavailability in beagle dogs

, 2015
Xuezhi Yin,1,3 Linda Sharon Daintree,2 Sheng Ding,3 Daniel Mark Ledger,2 Bing Wang,3 Wenwen Zhao,2 Jianping Qi,1 Wei Wu1 1Department of Pharmaceutics, School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery of Ministry of Education ...
Yin X, Qi J, Ding S, Wang B, Daintree LS, Zhao W, Wu W, Ledger DM   +7 more
core  

Selection of Solubility Enhancement Technologies for S-892216, a Novel COVID-19 Drug Candidate

Pharmaceutics
Background/Objectives: S-892216 is a poorly water-soluble drug developed as a novel oral treatment for COVID-19, although its oral absorption is low. For Phase 1 (Ph1) studies and commercial use, both oral solution and solid dispersion technologies are ...
Ryo Ohashi, Shuichi Otake, Tatsuhiko Murata, Ryosuke Watari, Shinpei Yoshida, Mikiko Kitade, Daisuke Kondo, Go Kimura   +7 more
doaj   +1 more source

Preparation, Characterization, and In Vitro Evaluation of Nitrendipine Solid Dispersions

, 2012
In order to enhance the absorption of dissolution rate of nitrendipine (NIT), solid dispersions were prepared using two water soluble carriers, polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 4000 (PEG-4000), by solvent and fusion method.
Dua, K, Hoon, TP, Rajendran, A, Gorajana, A, Pabreja, K   +4 more
core   +1 more source

REVIEW ARTICLE: SOLUBILITY ENHANCEMENT BY SOLID DISPERSION

, 2017
Enhancement of solubility, dissolution rate and bioavailability of the drug is a very challenging task in drug development, nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs. The solubility behaviour of the
R. B. Saudagar, A. N. Patil, D. M. Shinkar   +2 more
core   +2 more sources

Solid dispersion: application and limitations: Solid dispersion Application and limitations

Solubility and dissolution rate are essential factors in the bioavailability of a drug. The drug must be well-soluble in water to have good bioavailability.
Mohammed, Ebtissam Ameer, Alfahad, Mohanad, Qazzaz, Mohannad E   +2 more
core   +1 more source