Results 111 to 120 of about 130,260 (303)

Development of ternary solid dispersions with hydrophilic polymer and surface adsorbent for improving dissolution rate of carbamazepine

Saudi Pharmaceutical Journal, 2018
In this study solid dispersions of carbamazepine in the hydrophilic Kollidon® VA64 polymer, adsorbed onto Neusilin® UFL2 adsorption carrier have been employed to improve carbamazepine dissolution rate.
Tanja Vojinović, Djordje Medarević, Edina Vranić, Zorica Potpara, Marko Krstić, Jelena Djuriš, Svetlana Ibrić   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Magnon Damping by magnon-phonon coupling in Manganese Perovskites

, 1999
Inelastic neutron scattering was used to systematically investigate the spin-wave excitations (magnons) in ferromagnetic manganese perovskites. In spite of the large differences in the Curie temperatures ($T_C$s) of different manganites, their low ...
A. H. Moudden, A. J. Millis, C. Kloc, C. Zener, G. H. Jonker, G. Khaliullin, H. Kawano, H. Röder, H. Y. Hwang, H. Y. Hwang, H. Y. Hwang, I. V. Solovyev, J. A. Fernandez-Baca, J. A. Fernandez-Baca, J. W. Lynn, J.-H. Park, J.-S. Zhou, Jiandi Zhang, K. H. Kim, K. Kubo, L. Vasiliu-Doloc, M. C. Martin, N. Furukawa, Pengcheng Dai, S. W. Lovesey, S.-W. Cheong, T. A. Kaplan, T. G. Perring, T. Izuyama, W. Heisenberg, X. D. Wang, Y. Tokura, Y. Tomioka   +32 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Rheology of Titania Based Ceramic Nanodispersions Stabilized by Cationic Comb Copolymers

Applied Rheology, 2016
Rheological studies of the ceramic based concentrated titania nanoparticle dispersions showed a clear correlation between molecular structure of the cationic polymers used as dispersants and the viscosity of the slurries.
Klimkevicius Vaidas, Makuska Ricardas, Graule Thomas   +2 more
doaj   +1 more source

Dynamic spin-lattice coupling and nematic fluctuations in NaFeAs

, 2018
We use inelastic neutron scattering to study acoustic phonons and spin excitations in single crystals of NaFeAs, a parent compound of iron pnictide superconductors.
Chen, Tong, Chi, Songxue, Cui, Shifeng, Dai, Pengcheng, Fang, Ziming, Guo, Wenan, Hu, Ding, Li, Yu, Liu, Yi, Song, 2 Yu, Tam, 1 David W., Wang, 1 Weiyi, Xia, Ke, Xu, Zhuang, Yamani, 1 Zahra, Zhang, 1 Chenglin, Zhang, Li   +16 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Energy bands of atomic monolayers of various materials: Possibility of energy gap engineering

, 2010
The mobility of graphene is very high because the quantum Hall effects can be observed even at room temperature. Graphene has the potential of the material for novel devices because of this high mobility.
Guzmán-Verri, Klintenberg, Latil, Lebègue, Miyake, Nagashima, Nagashima, Novoselov, Novoselov, Tatsuo Suzuki, Trevisanutto, Yang, Yushi Yokomizo   +12 more
core   +1 more source

SOLID DISPERSION: ITS TYPES AND MECHANISM OF ENHANCEMENT OF SOLUBILITY BY SOLID DISPERSION

, 2019
ABSTRACT To improve dissolution of poorly water-soluble drugs and thus enhancing their bioavailability, the dispersion of one or more active pharmaceutical ingredient in a carrier at solid state is used. This process is known as solid dispersion. It has engrossed significant interest as an efficient means of improving the dissolution rate.
openaire   +2 more sources