Results 81 to 90 of about 128,995 (308)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Cosmology with velocity dispersion counts: an alternative to measuring cluster halo masses [PDF]

, 2016
The evolution of galaxy cluster counts is a powerful probe of several fundamental cosmological parameters. A number of recent studies using this probe have claimed tension with the cosmology preferred by the analysis of the Planck primary CMB data, in ...
Baldry, I. K., Bird, S., Caldwell, C. E., Collins, C. A., McCarthy, I. G., Schaye, J.   +5 more
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

A Quaternary Solid Dispersion System for Improving the Solubility of Olaparib

Solids
To improve the low solubility of poorly water soluble olaparib, in the following study, we prepared olaparib-loaded quaternary solid dispersions with hypromellose, Tween 20 or Labrasol, and colloidal silica.
Tae-Han Yun, Jeong-Gyun Lee, Kyu-Ho Bang, Jung-Hyun Cho, Kyeong-Soo Kim   +4 more
doaj   +1 more source

Phase behaviour of charged colloidal sphere dispersions with added polymer chains

, 2005
We study the stability of mixtures of highly screened repulsive charged spheres and non-adsorbing ideal polymer chains in a common solvent using free volume theory.
Aarts D G A L, Andrea Fortini, Belloni L, Dijkstra M, Dijkstra M, Donnan F G, Donnan F G, Frenkel D, Hansen J-P, Hebert T T, Lekkerkerker H N W, Louis A A, Löwen H, Marjolein Dijkstra, Pieranski P, Poon W C K, Remco Tuinier, Russel W B, Van Helden A K, Verwey E J W, Vrij A, Widom B, Ya Grinberg V   +22 more
core   +1 more source

Direct numerical simulations for non-Newtonian rheology of concentrated particle dispersions [PDF]

, 2009
The non-Newtonian behavior of a monodisperse concentrated dispersion of spherical particles was investigated using a direct numerical simulation method, that takes into account hydrodynamic interactions and thermal fluctuations accurately.
A. Einstein, R. G. Larson, Ryoichi Yamamoto, Takuya Iwashita, W. B. Russel   +4 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Phonons and related properties of extended systems from density-functional perturbation theory

, 2000
This article reviews the current status of lattice-dynamical calculations in crystals, using density-functional perturbation theory, with emphasis on the plane-wave pseudo-potential method.
Ackland, G. J., Adler, C., Ancilotto, F., Andrea Dal Corso, Baroni, S., Baroni, S., Baroni, S., Baroni, S., Baroni, S., Baroni, S., Baroni, S., Bauer, R., Bauer, R., Becke, A. D., Bertoni, C. M., Blat, D. Kh., Born, M., Bungaro, C., Bungaro, C., Bungaro, C., Buongiorn Nardelli, M., Buongiorno Nardelli, M., Car, R., Ceperley, D. M., Cochran, W., Cockayne, E., Colombo, L., Dal Corso, A., Dal Corso, A., Dal Corso, A., Dal Corso, A., Dal Corso, A., Dal Corso, A., De Cicco, P. D., de Gironcoli, S., de Gironcoli, S., de Gironcoli, S., de Gironcoli, S., de Gironcoli, S., de Gironcoli, S., de Gironcoli, S., Debernardi, A., Debernardi, A., Debernardi, A., Debernardi, A., Debernardi, A., Debernardi, A., Debernardi, A., Debernardi, A., Debernardi, A., Detraux, F., Detraux, F., Eckl, C., Eckl, C., Einarsdotter, K., Eklund, P. C., Favot, F., Feynman, R. P., Fleszar, A., Fleszar, A., Frank, W., Fritsch, J., Fritsch, J., Fritsch, J., Fritsch, J., Fritsch, J., Fritsch, J., Fu, C.-L., Gammon, D., Gaál-Nagy, K., Gerratt, J., Ghandehari, K., Ghosez, Ph., Ghosez, Ph., Ghosez, Ph., Ghosez, Ph., Ghosez, Ph., Ghosez, Ph., Ghosez, Ph., Giannozzi, P., Giannozzi, P., Giannozzi, P., Gonze, X., Gonze, X., Gonze, X., Gonze, X., Gonze, X., Gonze, X., Gonze, X., Gonze, X., Gonze, X., Grosche, E. G., Guha, S., Hamann, D. R., Hedin, L., Heid, R., Heid, R., Heid, R., Herman, F., Hohenberg, P., Honke, R., Honke, R., Hybertsen, M. S., Jones, R. O., Kane, E. O., Karch, K., Karch, K., Karch, K., Karch, K., Karch, K., Karki, B. B., Karki, B. B., Kechrakos, D., Kern, G., Kim, K., King-Smith, R. D., King-Smith, R. D., Kingma, K. J., Kingma, K. J., Kleinman, L., Klotz, S., Kohanoff, J., Kohanoff, J., Kohanoff, J., Kohn, W., Kulda, J., Kuzmany, H., Laasonen, K., Lang, G., LaSota, C., LaSota, C., Lazzari, R., Lazzeri, M., Lazzeri, M., Lee, C., Lee, C., Lee, C., Lee, C., Littlewood, P. B., Liu, A. Y., Liu, A. Y., Liu, J., Louie, S. G., Mahan, G. D., Mao, H. K., Mao, H. K., Martin, M. C., Martin, R. M., Martyna, G. J., Marzari, N., Mauri, F., Mauri, F., Meregalli, V., Mermin, N. D., Methfessel, M., Molinari, E., Mäder, K. A., Nielsen, O. H., Nielsen, O. H., Nunes, R. W., Ortiz, G., Ozoliņš, V., Ozoliņš, V., Ozoliņš, V., Panella, V., Paolo Giannozzi, Parlinski, K., Parlinski, K., Parlinski, K., Pavone, P., Pavone, P., Pavone, P., Pavone, P., Payne, M. C., Perdew, J. P., Perdew, J. P., Perdew, J. P., Persson, K., Persson, K., Pichler, T., Pick, R., Pickett, W. E., Posternak, M., Pulay, P., Quong, A. A., Quong, A. A., Quong, A. A., Rabe, K. M., Rahman, A., Rappe, A. M., Resta, R., Resta, R., Resta, R., Rignanese, G. M., Robbie, D. A., Robbie, D. A., Roma, G., Rossi, F., Rudin, S. P., Saad, Y., Saitta, A. M., Savrasov, S. Y., Savrasov, S. Y., Savrasov, S. Y., Savrasov, S. Y., Savrasov, S. Y., Savrasov, S. Y., Schorer, R., Schwoerer-Böhning, M., Schütt, O., Stefano Baroni, Stefano de Gironcoli, Steininger, B., Sternheimer, R. M., Stigler, W., Stigler, W., Sághi-Szabó, G., Troullier, N., Vanderbilt, D., Vanderbilt, D., Vanderbilt, D., Vast, N., Vast, N., Waghmare, U. V., Waghmare, U. V., Wagner, J.-M., Wang, C.-Z., Wang, C.-Z., Wang, C.-Z., Wang, C.-Z., Wei, S., Wei, S., Wei, S., Wellenhofer, G., Widulle, F., Widulle, F., Windl, W., Windl, W., Windl, W., Xie, J., Xie, J., Xie, J.,, Yin, T. M, Yu, R., Yu, R., Zein, E. N., Zein, E. N., Zein, E. N., Zhang, J. M., Zunger, A., Öğüt, S., Štich, I.   +251 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source