Results 71 to 80 of about 1,687,750 (295)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Nimodipino: do polimorfismo à obtenção de dispersões sólidas amorfas destinadas ao tratamento da hipertensão arterial [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.A baixa solubilidade de fármacos apresenta-se como um dos aspectos mais desafiadores no ...
Riekes, Manoela Klüppel
core  

Topical Meloxicam Hydroxypropyl Guar Hydrogels Based on Low-Substituted Hydroxypropyl Cellulose Solid Dispersions [PDF]

Meloxicam (MX) is a poorly water-soluble drug with severe gastrointestinal side effects. Topical hydrogel of hydroxypropyl guar (HPG) was formulated using a solid dispersion (SD) of MX with hydroxypropyl cellulose (LHPC) as an alternative to oral ...
Víctor Guarnizo-Herrero, Torrado Salmerón, Carlos Félix, Álvarez Álvarez, Covadonga, Torre Iglesias, Paloma de la, Martínez Alonso, Borja, Guarnizo Herrero, Víctor, Torrado Durán, Guillermo, Guillermo Torrado, Dahma, Zaid, Martínez-Alonso, Borja, Paloma Marina de la Torre-Iglesias, Torrado, Guillermo, Zaid Dahma, Álvarez Álvarez, Covandonga, Torre Iglesias, Paloma Marina De La, Santiago Torrado-Santiago, Guarnizo-Herrero, Víctor, Torrado Durán, Santiago, Carlos Torrado-Salmerón, Covadonga Álvarez-Álvarez, Borja Martínez-Alonso   +20 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Solubility enhancement of benfotiamine, a lipid derivative of thiamine by solid dispersion technique

Journal of Pharmacy and Bioallied Sciences, 2012
The present study was aimed to increase the solubility of the poorly water soluble drug benfotiamine using hydrophilic polymers (PVP K-30 and HPMC E4). Solid dispersions were prepared by kneading method.
S M Patel, R P Patel, B G Prajapati
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Preparation, Characterization and In Vitro Evaluation of Aceclofenac Solid Dispersions [PDF]

, 2010
The objective of the present investigation was to study the effect of various water soluble carriers like urea, mannitol, PVP and PVP/VA-64 on in vitro dissolution of aceclofenac from solid dispersions.
Pabreja, Kavita, Ramana, MV, Dua, Kamal, Ramana, M.V., Ramana, M. V., Kamal, Dua   +5 more
core   +2 more sources

Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015

Molecules, 2018
Background: Solid dispersions are an effective formulation technique to improve the solubility, dissolution rate, and bioavailability of water-insoluble drugs for oral delivery.
Jinglu Zhang, Run Han, Weijie Chen, Weixiang Zhang, Ying Li, Yuanhui Ji, Lijiang Chen, Hao Pan, Xinggang Yang, Weisan Pan, Defang Ouyang   +10 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

STUDIES ON SOLID DISPERSIONS OF LEFLUNOMIDE [PDF]

, 2020
Objective: Leflunomide is Non steroidal Anti-Inflammatory drug, which is poorly water soluble. In present study attempt has been made to prepare and characterize solid dispersions of leflunomide to increase solubility of drug.Method:  In Preparation of ...
VP, THORAT, PR, MAHAPARALE
core   +1 more source