Results 301 to 310 of about 327,171 (380)

Solid Phase Peptide Synthesis

Journal of Macromolecular Science: Part A - Chemistry, 1976
Abstract The last two decades have been an era of rapid progress in peptide research. This era was begun by the work of Sanger on the amino acid sequence determination of insulin and by du Vigneaud on the structure determination and synthesis of oxytocin.
BRUCE W. ERICKSON, R.B. MERRIFIELD
semanticscholar   +3 more sources

Fmoc Solid-Phase Peptide Synthesis

Methods in molecular biology, 2015
Synthetic peptides are important as drugs and in research. Currently, the method of choice for producing these compounds is solid-phase peptide synthesis. In this nonspecialist review, we describe the scope and limitations of Fmoc solid-phase peptide synthesis. Furthermore, we provide a detailed protocol for Fmoc peptide synthesis.
Hansen, Paul Robert, Oddo, Alberto
openaire   +5 more sources

Solid-Phase Peptide Synthesis

Chemical Approaches to the Synthesis of Peptides and Proteins, 2020
Paul Lloyd-Williams, Fernando Albericio, Ernest Giralt   +2 more
semanticscholar   +3 more sources

Convergent solid-phase peptide synthesis

Tetrahedron, 1993
The solid-phase synthesis, photolytic detachment from the solid support and purification in solution, of a fully-protected octapeptide containing a methionine residue (protected as the sulphoxide) is described. Protection of methionine in this manner avoids problems associated with the oxidation of this residue during the photolysis.
F, Albericio, P, Lloyd-Williams, E, Giralt   +2 more
openaire   +2 more sources

Making Solid-Phase Peptide Synthesis Greener: A Review of the Literature.

Chemistry - An Asian Journal, 2019
To date, the synthesis of peptides is concurrent with the production of enormous amounts of toxic waste. DMF, CH2 Cl2 , and NMP are three of the most toxic organic solvents used in chemical synthesis and are the most common solvents used for peptide ...
Kyriakos G Varnava, V. Sarojini
semanticscholar   +1 more source

Green Transformation of Solid-Phase Peptide Synthesis

ACS Sustainable Chemistry and Engineering, 2019
Peptides play key roles in medicinal chemistry, being found in therapeutics and diagnostic agents, among others. Furthermore, their synthetic protocols have also been optimized for other fields such as the solid-phase organic synthesis of other organic ...
Yahya E. Jad, Ashish Kumar, A. El‐Faham, B. G. de la Torre, F. Albericio   +4 more
semanticscholar   +1 more source

Troubleshooting When Using γ-Valerolactone (GVL) in Green Solid-Phase Peptide Synthesis

Organic Process Research & Development, 2019
The synthesis of peptides for both research and API production is conveniently carried out using the solid-phase strategy. However, the main drawback of this approach is the large amounts of hazardous solvents required.
Ashish Kumar, Adeniyi T. Adewumi, K. Nandhini, Jonathan M. Collins, F. Albericio, F. Albericio, B. G. Torre   +6 more
semanticscholar   +1 more source

Biofunctionalization of Nano Channels by Direct In-Pore Solid-Phase Peptide Synthesis.

Chemistry, 2018
Diatom biosilica are highly complex inorganic/organic hybrid materials. To get deeper insights on their structure at a molecular level, model systems that mimic the complex natural compounds were synthesized and characterized.
M. Brodrecht, H. Breitzke, T. Gutmann, G. Buntkowsky   +3 more
semanticscholar   +1 more source

Solid‐phase peptide synthesis on proteins

International Journal of Peptide and Protein Research, 1993
A new method for solid‐phase peptide synthesis in which a protein is used as the solid support has been developed. Two aspects of the method have been demonstrated. The peptides H‐Phe‐Leu‐Glu‐Glu‐Val‐OH (1) and H‐Leu‐Leu‐Ala‐Glj‐Val‐OH (2), respectively, were synthesized on the amino groups of BSA via a cleaveable linker, using the Fmoc group ...
Hansen, Paul Robert, Holm, Arne, Houen, Gunnar   +2 more
openaire   +2 more sources

Automated Solid-Phase Peptide Synthesis

2019
The development of solid-phase peptide synthesis by Bruce Merrifield paved the way for a synthesis carried out by machines. Automated peptide synthesis is a fast and convenient way of synthesizing many peptides simultaneously. This chapter tries to give a general guidance for the development of synthesis protocols for the peptide synthesizer.
openaire   +2 more sources