Results 311 to 320 of about 327,171 (380)
Some of the next articles are maybe not open access.
Solid-Phase Synthesis of Fullerene-peptides
Journal of the American Chemical Society, 2002The solid-phase synthesis of peptides (SPPS) containing [60]fullerene-functionalized amino acids is reported. A new amino acid, fulleropyrrolidino-glutamic acid (Fgu), is used for the SPPS of a series of analogues of different length based on the natural Leu(5)-Enkephalin and on cationic antimicrobial peptides.
PANTAROTTO, DAVIDE +7 more
openaire +3 more sources
Solid phase synthesis of peptide-selenoesters
Bioorganic & Medicinal Chemistry, 2013The synthesis of proteins by native chemical ligation greatly enhances the application of chemistry to complex molecules such as proteins. The essential building blocks for this approach traditionally have been peptide-thioester segments that are linked chemoselectively in consecutive reactions.
Ghassemian, Artin +3 more
openaire +3 more sources
Solid‐Phase Synthesis of DOTA–Peptides
Chemistry – A European Journal, 2004AbstractA general synthetic route to two DOTA‐linked N‐Fmoc amino acids (DOTA‐F and DOTA‐K) is described that allows insertion of DOTA at any endo‐position within a peptide sequence. Three model pentapeptides were prepared to test the general utility of these derivatives in solid‐phase peptide synthesis.
Luis M, De León-Rodriguez +3 more
openaire +2 more sources
Solid-Phase Synthesis of Lipidated Peptides
Journal of the American Chemical Society, 2002Characteristic partial structures of lipidated proteins embodying different lipid groups as well as additional fluorescent tags or a maleimide for coupling to proteins can be synthesized readily by means of a new solid-phase technique employing the oxidative cleavage of the hydrazide linker as well as on-resin farnesylation and palmitoylation after ...
Ludolph, B., Eisele, F., Waldmann, H.
openaire +3 more sources
Apparatus for Solid-Phase Peptide Synthesis
Science, 1967The apparatus, designed for solid-phase peptide synthesis, consists of a round-bottom flask, rocked on a wrist-shaker, and fitted with a special dropping funnel and a fritted filter disc embedded within the flask. The dropping funnel is designed to wash down the polymer adhering to the neck of the flask.
M C, Khosla, R R, Smeby, F M, Bumpus
openaire +2 more sources
Analytical Methods for Solid Phase Peptide Synthesis
Current Organic Chemistry, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
SABATINO, GIUSEPPINA +3 more
openaire +4 more sources
1991
This chapter discusses solid phase peptide synthesis, an idea which first appeared in a scientific publication by Merrifield in 1963. It explains why the term ‘solid phaseȉ is misleading, elaborating that the reactions do not take place in or on the surfaces of solid phases, but in gel systems produced by the penetration of solvent and solute molecules
openaire +1 more source
This chapter discusses solid phase peptide synthesis, an idea which first appeared in a scientific publication by Merrifield in 1963. It explains why the term ‘solid phaseȉ is misleading, elaborating that the reactions do not take place in or on the surfaces of solid phases, but in gel systems produced by the penetration of solvent and solute molecules
openaire +1 more source
Convergent solid‐phase peptide synthesis
International Journal of Peptide and Protein Research, 1991The solid‐phase synthesis, photolytic detachment from the solid support and purification in solution, of a fully‐protected octapeptide containing a methionine residue (protected as the sulphoxide) is described. Protection of methionine in this manner avoids problems associated with the oxidation of this residue during the photolysis.
PAUL LLOYD‐WILLIAMS +2 more
openaire +1 more source
1994
Abstract The chemical synthesis of oxytocin, with biological activity indistinguishable from that of the native hormone, by du Vigneaud and co-workers in 1953, represents a landmark in the application of synthetic peptides to the study of biology (1).
openaire +1 more source
Abstract The chemical synthesis of oxytocin, with biological activity indistinguishable from that of the native hormone, by du Vigneaud and co-workers in 1953, represents a landmark in the application of synthetic peptides to the study of biology (1).
openaire +1 more source