Realizing Serine/Threonine Ligation: Scope and Limitations and Mechanistic Implication Thereof
Frontiers in Chemistry, 2014 Serine/Threonine ligation (STL) has emerged as an alternative tool for protein chemical synthesis, bioconjugations as well as macrocyclization of peptides of various sizes. Owning to the high abundance of Ser/Thr residues in natural peptides and proteins,
Clarence T. T. Wong +10 more
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Development of a hypersensitive periodate-cleavable amino acid that is methionine- and disulfide-compatible and its application in MHC exchange reagents for T cell Characterisation [PDF]
, 2012 Incorporation of cleavable linkers into peptides and proteins is of particular value in the study of biological processes. Here we describe the synthesis of a cleavable linker that is hypersensitive to oxidative cleavage as the result of the periodate ...
Altman +28 more
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Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles
Applied Sciences, 2013 We have previously developed water-based microwave (MW)-assisted peptide synthesis using Fmoc-amino acid nanopaticles. It is an organic solvent-free, environmentally friendly method for peptide synthesis.
Yoshinobu Fukumori +4 more
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Chemistry of Peptide-Oligonucleotide Conjugates: A Review
Molecules, 2021 Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency of therapeutic nucleic acids, such as ...
Kristina Klabenkova +2 more
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Solid-Phase Synthesis of the Lipopeptide Myr-HBVpreS/2-78, a Hepatitis B Virus Entry Inhibitor
Molecules, 2010 Chronic HBV infection is the leading cause of liver cirrhosis and hepatocellular carcinoma (HCC). Synthetic peptides derived from the N-terminus of the large HBV envelope protein (L-protein) have been shown to efficiently block HBV entry.
Walter Mier +5 more
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Liquid-Phase Peptide Synthesis (LPPS): A Third Wave for the Preparation of Peptides.
Chemical Reviews, 2022 Since the last century, peptides have gained wide acceptance as drugs, with almost 100 already in the market and a large number in the pipeline. In this context, peptide synthesis has grown massively as a stringent field for pharmaceuticals around the ...
Anamika Sharma +3 more
semanticscholar +1 more source
Heat-enhanced peptide synthesis on Teflon-patterned paper [PDF]
, 2016 In this report, we describe the methodology for 96 parallel organic syntheses of peptides on Teflon-patterned paper assisted by heating with an infra-red lamp.
Deiss, Frédérique +3 more
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Nature Communications, 2020 Aspartimide formation is a frequently occurring problem during peptide synthesis. Here, the authors present cyanosulfurylides as a protection group that masks aspartic acid residues during solid phase peptide synthesis, thus preventing aspartimide ...
Kevin Neumann +3 more
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DNA display III. Solid-phase organic synthesis on unprotected DNA. [PDF]
PLoS Biology, 2004 DNA-directed synthesis represents a powerful new tool for molecular discovery. Its ultimate utility, however, hinges upon the diversity of chemical reactions that can be executed in the presence of unprotected DNA.
David R Halpin +3 more
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A facile, inexpensive scalable route to α-methyl cysteine [PDF]
, 2013 A facile, scalable synthesis of α-methyl cysteine with three alternate thiol protecting groups (Trt, Allyl and tBu) is described. The thiol protected amino acids are obtained in 6 steps from L-cysteine ethyl ester and are ideally suited for a range of ...
Hulme, Alison N, Johnston, Heather J
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