Results 101 to 110 of about 415,803 (302)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

SYNTHESIS OF OLIGOPEPTIDES OF DEFINED FRAGMENT COMPOSITION [PDF]

Journal of IMAB, 2011
The advantages of the solid-phase peptide synthesis were used. The peptide chain was built on specially processed insoluble polymer resin: Wang- and Rink Amide MBHA-resin.
Tamara Paypanova, Tatyana Hristova, Rumyana Cherkezova   +2 more
doaj  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Solid-Phase Synthesis of Fullerene-peptides [PDF]

, 2016
The solid-phase synthesis of peptides (SPPS) containing [60]fullerene-functionalized amino acids is reported. A new amino acid, fulleropyrrolidino-glutamic acid (Fgu), is used for the SPPS of a series of analogues of different length based on the natural
Davide Pantarotto (2680936), Maurizio Prato (444708), Alessandro Tossi (381543), Igor Zelezetsky (2990463), Jean-Paul Briand (39159), Anna Giangaspero (2990466), Federica Pellarini (2990460), Alberto Bianco (151604)   +7 more
core   +1 more source

Ultra-fast synthesis and composition-dependent formation behavior of (HfxZr1−x)B2 solid solution nanopowders

Journal of Advanced Ceramics
Ultrafine boride solid solutions offer immense potential for extreme environmental applications, yet their rapid synthesis with nanoscale compositional control remains a challenge.
Sen Yang, Zhengang Zhang, Yanqin Fu, Tao Li, Liyuan Han, Lingxiang Guo, Hang Yu, Jianhua Zhang, Wei Xie, Hailong Wang, Yulei Zhang   +10 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

High throughput methodology for synthesis, screening, and optimization of solid state Lithium ion electrolytes [PDF]

, 2011
A study of the lithium ion conductor Li3xLa2/3–xTiO3 solid solution and the surrounding composition space was carried out using a high throughput physical vapor deposition system.
Yokoishi, Shoji, Xiaojuan Lu, Denis Pasero, Duncan C. A. Smith, Thierry Le Gall, Shoji Yokoishi, Yada, Chihiro, Chihiro Yada, Andrew Weld, Christopher E. Lee, Le Gall, Thierry, Pasero, Denis, Lu, Xiaojuan, Mormiche, Claire, Beal, Mark, Mark S. Beal, Mehdi Mirsaneh, Mirsaneh, Mehdi, Weld, Andrew, Claire Mormiche, Hayden, Brian E., Brian E. Hayden, Lee, Christopher E., Smith, Duncan C.A.   +23 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Solid-Phase Synthesis of β‑Hydroxy Ketones Via DNA-Compatible Organocatalytic Aldol Reactions [PDF]

, 2018
One-bead one-compound (OBOC) libraries constructed by solid-phase split-and-pool synthesis are a valuable source of protein ligands. Most OBOC libraries are composed of oligoamides, particularly peptides, peptoids, and peptoid-inspired molecules. Further
Keitou Shu (5052467), Thomas Kodadek (61725)   +1 more
core   +1 more source