Results 91 to 100 of about 415,803 (302)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Solid-Phase Synthesis of Naltrindole Derivatives Using Fischer Indole Synthesis Based on One-Pot Release and Cyclization Methodology [PDF]
, 2016 We describe a new approach for the solid-phase synthesis of indoles 1 that involves a one-pot release and cyclization reaction of a solid-supported hydrazone through a Wang-type linker. Using this solid-phase methodology, we accomplished the synthesis of
Hiroshi Tanaka (3087) +5 more
core +1 more source
Automated Synthesis of Oligosaccharides Provides Access to Chemical Tools and Vaccine Candidates
CHIMIA, 2008 Defined, pure oligosaccharides are important tools for biologists to study the structure and function of carbohydrates in biological systems and to create novel diagnostic and therapeutic approaches.
Lenz Kröck, Peter H. Seeberger
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives
Molecules, 2011 A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were
Shaorong Wang, Weishuo Fang
doaj +1 more source
FEBS Open Bio, EarlyView.Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley +1 more source
Pushing the Limits of Solid-Phase Peptide Synthesis with Continuous Flow [PDF]
Since its invention by Bruce Merrifield, solid-phase peptide synthesis has conventionally been performed in batch reactors. With systems created by Atherton, Dryland, and Sheppard in the 1980s, flow-chemistry techniques began to be applied to enhance ...
Steinauer, Angela +3 more
core +1 more source
Solid-Phase Total Synthesis of Scytalidamide A [PDF]
, 2016 The first total synthesis of the natural cyclic heptapeptide scytalidamide A was achieved on solid phase using two different resins, a phenylalanine silane resin and a 4-methoxybenzaldehyde backbone linker resin.
Wenxin Gu (1764613) +1 more
core +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Solid-Phase Enzymatic Synthesis of Oligonucleotides† [PDF]
, 2016 The controlled and selective synthesis of oligonucleotides on the solid phase is possible under mild aqueous conditions using the enzyme T4 RNA ligase, the resins being tentagel or kieselguhr ...
Carole Schmitz (3075507) +1 more
core +1 more source