Results 81 to 90 of about 415,803 (302)

Deprotection Strategies for Thioimidates During Fmoc Solid-Phase Peptide Synthesis: A Safe Route to Thioamides [PDF]

, 2019
Thioamides are important biophysical probes of peptide folding, but are prone to alpha-C epimerization during Fmoc solid-phase peptide synthesis. The stereochemical integrity of thioamide-containing peptides can be dramatically improved by protecting the
john, turner, Yen, Nguyen, Brett, VanVeller, luis, camacho III   +3 more
core   +1 more source

TiO2 phase-controlled synthesis of Li-La-TiO solid electrolytes for advanced all-solid-state batteries

Journal of Asian Ceramic Societies
This study focused on achieving high ionic conductivity in Li-La-TiO (LLTO) solid electrolyte. To enhance ionic conductivity, the synthesis reaction was optimized by controlling the composite crystal structure of TiO2 at the B-site of the perovskite ...
Minjeong Kim, Wolil Nam, Jihye Seo, Jihyun Park, Seokha Heo, Yuna Hwang, Sang-Soo Chee, Soobeom Lee, Seungchan Cho, Geon−hyoung An, Yangdo Kim, Moonhee Choi   +11 more
doaj   +1 more source

Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones

Molecules, 2011
A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N ...
Yilmaz Yildirir, Naki Colak, Hamdi Ozkan, Serkan Yavuz   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Promotion of 211 MAX Phase Formation through Bismuth A‐Site Solid Solution in Ti2(Al1‐xBix)C

Small Structures
Solid‐solution engineering is a powerful strategy for expanding the chemical diversity and functional tunability of MAX phases. In this study, we realize Ti2(Al1‐xBix)C MAX phase solid solutions via reactive synthesis, demonstrating that an A‐site solid ...
Yiftach Kushnir, Bar Favelukis, Martin Dahlqvist, Mark Baranov, Asaf Nitsan, Or Messer, Avia Greenberg, Alexander Upcher, Nitzan Maman, Johanna Rosen, Barak Ratzker, Maxim Sokol   +11 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Phase Equilibrium and Optimization Tools: Application for Enhanced Structured Lipids for Foods [PDF]

, 2010
Solid-liquid phase equilibrium modeling of triacylglycerols mixtures is essential for lipids design. Considering the α polymorphism and liquid phase as ideal, the Margules 2-suffix excess Gibbs energy model with predictive binary parameter correlations ...
SANTOS, Moises Teles dos, Moises Teles dos Santos, Teles dos Santos, Moises, Carrillo Le Roux, Galo, Vincent Gerbaud, Galo A. C. Le Roux, Gerbaud, Vincent, ROUX, Galo A. C. Le   +7 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Insights into the preparation of selenopeptides awaiting functional validation for fatigue mitigation: a comprehensive review

Food Science of Animal Products
Fatigue, a debilitating condition arising from intense physical and mental stress, significantly impairs work capacity and well-being, yet effective molecular interventions remain scarce.
Yuxiao Guo, Wei Jia, Rong Zhang, Bo He, Fen Ao, Haizhen Mo   +5 more
doaj   +1 more source

From Polymer to Small Organic Molecules: A Tight Relationship between Radical Chemistry and Solid-Phase Organic Synthesis

Molecules, 2011
Since Gomberg’s discovery of radicals as chemical entities, the interest around them has increased through the years. Nowadays, radical chemistry is used in the synthesis of 75% of all polymers, inevitably establishing a close relationship with Solid ...
Danilo Mirizzi, Maurizio Pulici
doaj   +1 more source