Results 71 to 80 of about 414,318 (301)

Solid-Phase Synthesis of Nannocystin Ax and Its Analogues

, 2023
Solid-phase total synthesis of nannocystin Ax (1) was disclosed. A coupling reaction between a peptide and a polyketide moiety was conducted on a solid support, and macrocyclization was achieved by Mitsunobu cyclization.
Satoshi Ichikawa, Kohei Kawanishi (16616712), Fumika Yakushiji, Satoshi Ichikawa (1310742), Fumika Yakushiji (1639009), Kazuki Yamamoto (1475920), Daiki Miyakita, Kohei Kawanishi, Akira Katsuyama (2796379), Akira Katsuyama, Daiki Miyakita (16616709), Kazuki Yamamoto   +11 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

TiO2 phase-controlled synthesis of Li-La-TiO solid electrolytes for advanced all-solid-state batteries

Journal of Asian Ceramic Societies
This study focused on achieving high ionic conductivity in Li-La-TiO (LLTO) solid electrolyte. To enhance ionic conductivity, the synthesis reaction was optimized by controlling the composite crystal structure of TiO2 at the B-site of the perovskite ...
Minjeong Kim, Wolil Nam, Jihye Seo, Jihyun Park, Seokha Heo, Yuna Hwang, Sang-Soo Chee, Soobeom Lee, Seungchan Cho, Geon−hyoung An, Yangdo Kim, Moonhee Choi   +11 more
doaj   +1 more source

From Polymer to Small Organic Molecules: A Tight Relationship between Radical Chemistry and Solid-Phase Organic Synthesis

Molecules, 2011
Since Gomberg’s discovery of radicals as chemical entities, the interest around them has increased through the years. Nowadays, radical chemistry is used in the synthesis of 75% of all polymers, inevitably establishing a close relationship with Solid ...
Danilo Mirizzi, Maurizio Pulici
doaj   +1 more source

Solid Phase Peptide Synthesis: Analysis and Identification of Protein Kinase Substrates

, 2005
This research study examines the synthesis of tyrosine containing peptides based on the protein paxillin. Paxillin is a proposed substrate of the Focal Adhesion Kinase (FAK) protein tyrosine kinase.
Kroodsma, Derrick
core  

Rapid microwave-assisted solid phase peptide synthesis

, 2002
A microwave-assisted, rapid solid phase peptide synthesis procedure is presented. It has been applied to the coupling of sterically hindered Fmoc-protected amino acids yielding di- and tripeptides.
Gogoll, Adolf,, Erdelyi, Mate,
core   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Promotion of 211 MAX Phase Formation through Bismuth A‐Site Solid Solution in Ti2(Al1‐xBix)C

Small Structures
Solid‐solution engineering is a powerful strategy for expanding the chemical diversity and functional tunability of MAX phases. In this study, we realize Ti2(Al1‐xBix)C MAX phase solid solutions via reactive synthesis, demonstrating that an A‐site solid ...
Yiftach Kushnir, Bar Favelukis, Martin Dahlqvist, Mark Baranov, Asaf Nitsan, Or Messer, Avia Greenberg, Alexander Upcher, Nitzan Maman, Johanna Rosen, Barak Ratzker, Maxim Sokol   +11 more
doaj   +1 more source

Phase Equilibrium and Optimization Tools: Application for Enhanced Structured Lipids for Foods [PDF]

, 2010
Solid-liquid phase equilibrium modeling of triacylglycerols mixtures is essential for lipids design. Considering the α polymorphism and liquid phase as ideal, the Margules 2-suffix excess Gibbs energy model with predictive binary parameter correlations ...
SANTOS, Moises Teles dos, Moises Teles dos Santos, Teles dos Santos, Moises, Carrillo Le Roux, Galo, Vincent Gerbaud, Galo A. C. Le Roux, Gerbaud, Vincent, ROUX, Galo A. C. Le   +7 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source