Results 51 to 60 of about 415,803 (302)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Application of statistical process control to solid-phase synthesis of peptides [PDF]
, 2001 A non invasive on-line monitoring strategy based on conductimetric measurements and on statistical analysis is applied to the solid phase synthesis of ...
BAGNO, ANDREA +3 more
core
Organic Synthesis on Solid Phase. (Supports, Linkers, Reactions)
Molecules, 2001 n ...
Florencio Zaragoza Dörwald
doaj +1 more source
Practical Protocols for Solid-Phase Peptide Synthesis 4.0
Methods and Protocols, 2022 According to the Food and Drug Administration (FDA), there are two kinds of drugs, namely New Chemical Entities (NCEs) and Biologics [...]
Beatriz G. de la Torre +1 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The development of PolyHIPE monoliths for use as supports in organic synthesis [PDF]
, 2003 As part of the ongoing research efforts to discover alternative support materials to polymer beads for use in polymer-supported synthesis, particularly under flow-through, this project involved the synthesis of PolyHIPE (High Internal Phase Emulsion ...
Brown, Jane F., Brown, Jane F
core
CHIMIA, 1996 In this account dedicated to '100 years Roche' in CHIMIA, we present some of our strategies towards the synthesis of interesting novel amino-acid-derived building blocks; multigeneration synthesis of thiazole libraries in solution; a novel solid-
Alexander Chucholowski +4 more
doaj +2 more sources
Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate
Molecules, 2006 Direct, solid phase synthesis of an oligonucleotide conjugate of the antibioticdrug metronidazole was accomplished by the phosphoramidite method. Removal ofprotecting groups and cleavage from the controlled pore glass (CPG) solid support wassuccessful ...
William Fraser +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Facile solid-phase synthesis of biotinylated alkyl thiols [PDF]
, 2006 Biotinylated alkyl thiols with the capacity to graft avidin proteins are in increasing demand for the development of self-assembled monolayers on gold.
Samitier, Josep +7 more
core +1 more source