Results 51 to 60 of about 414,318 (301)
Total Synthesis of Cyclosenegalin A
ChemistryOpenA Pro‐Gly‐typed cyclopeptide, cyclosenegalin A, was firstly isolated from Annona senegalensis and Annona scleroderma. In this study, we reported synthesis the cycloheptapeptide with a combination of solid‐ and solution‐phase synthetic methods. This study
Anderson Arnold Aloanis +3 more
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Practical Protocols for Solid-Phase Peptide Synthesis 4.0
Methods and Protocols, 2022 According to the Food and Drug Administration (FDA), there are two kinds of drugs, namely New Chemical Entities (NCEs) and Biologics [...]
Beatriz G. de la Torre +1 more
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Solid-Phase Synthesis of BRL 49653
, 2016 Solid-Phase Synthesis of BRL ...
Kay M. Brummond (1334937) +1 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Scientific Reports, 2021 Synthesis technology for sulfide-based solid electrolytes based on liquid-phase processing has attracted significant interest in relation to achieving the optimal design for all-solid-state batteries.
Hirotada Gamo +2 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
SASRIN™ a Versatile Tool in Peptide Synthesis and Solid-Phase Organic Chemistry
CHIMIA, 1999 The synthesis of the 4-(3-methoxy-4-(hydroxymethyl)phenoxymethyl) derivative of polystyrene-co-divinylbenzene (SASRIN™), its derivatives and its application in solid-phase peptide synthesis will be briefly reviewed in this paper.
Monika Mergler +4 more
doaj
Solid‐Phase Supports for Oligonucleotide Synthesis [PDF]
Current Protocols in Nucleic Acid Chemistry, 2000 AbstractThis unit begins with a discussion of the advantages and disadvantages of oligonucleotide synthesis using solid supports. The physical and chemical properties of solid‐phase supports are discussed in terms of their suitability for oligonucleotide synthesis. In addition, the unit outlines the properties of linkers used for transient or permanent
openaire +4 more sources
Solid-Phase Synthesis of 6-Deoxyoligosaccharides
, 2016 Solid-Phase Synthesis of 6 ...
J. A. Hunt (2998107) +1 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source