Results 41 to 50 of about 415,803 (302)

Solid Phase Peptide Synthesis: Analysis and Identification of Protein Kinase Substrates [PDF]

open access: yes, 2005
This research study examines the synthesis of tyrosine containing peptides based on the protein paxillin. Paxillin is a proposed substrate of the Focal Adhesion Kinase (FAK) protein tyrosine kinase.
Kroodsma, Derrick
core   +1 more source

Rapid microwave-assisted solid phase peptide synthesis [PDF]

open access: yes, 2002
A microwave-assisted, rapid solid phase peptide synthesis procedure is presented. It has been applied to the coupling of sterically hindered Fmoc-protected amino acids yielding di- and tripeptides.
Gogoll, Adolf,, Erdelyi, Mate,
core   +1 more source

Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis

open access: yesGreen Chemistry Letters and Reviews, 2021
PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives.
Ashish Kumar   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Magnetic nanoparticle-based solid phase peptide synthesis and the synchronous detection of their biological activity

open access: yesMaterials Today Advances, 2021
The solid-phase peptide synthesis (SPPS) strategy, as the main procedure of peptide manufacturing, has a profound impact on the research of peptides.
D. Luo   +8 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Mechanochemical synthesis of AlCoCrFeNi powders via high-energy ball milling

open access: yesҚарағанды университетінің хабаршысы. Физика сериясы, 2023
AlCoCrFeNi powders in equimolar ratios were synthesized by mechanochemical synthesis on a high-energy ball milling machine (HEBM). The elemental and phase composition of AlCoCrFeNi powders before and after mechanochemical synthesis were investigated by ...
Е.Е. Камбаров   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

High pressure solid state chemistry of C-N-H and Ti-N systems [PDF]

open access: yes, 2010
This thesis presents the use of molecular precursors for the synthesis of solid-state materials through the application of extreme conditions. The main tool for the exploration of these materials was the diamond anvil cell which generated static ...
Salamat, N.
core  

Novel Solution- and Solid-Phase Syntheses of Heterocyclic Systems

open access: yesCHIMIA, 2003
Heterocyclic compounds are an attractive source of screening library structures because they possess varied structural diversity and can exhibit potent biological activity.
Gaelle Cabon   +4 more
doaj   +1 more source

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