Results 261 to 270 of about 414,318 (301)

An Automatic Solid-Phase Synthesis of Peptaibols

The Journal of Organic Chemistry, 2008
An automated approach to peptaibols using microwave-assisted solid-phase peptide synthesis is demonstrated with a combination of HBTU and acid fluoride mediated couplings for normal and alpha,alpha-dialkylated amino acids, respectively. The method is utilized for the automated synthesis of several full-length peptaibols, including alamethicin ...
Hjørringgaard, Claudia Ulrich, Pedersen, Jan Mondrup, Vosegaard, Thomas; id_orcid 0000-0001-5414-4550, Nielsen, Niels Christian, Skrydstrup, Troels   +4 more
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Solid-Phase Synthesis of CD40L Mimetics

Synfacts, 2006
The C3-symmetric molecule has been previously shown to mimic CD40 ligand (CD40L) homotrimers and to display effector functions. This molecule consists of a cyclic hexapeptide core containing the repetition of the D-Ala-L-Lys motif. The side chains of the lysine residues have been modified by appending the CD40L-derived sequence 143Lys-Gly-Tyr-Tyr146 ...
Alberto, Bianco, Sylvie, Fournel, Sébastien, Wieckowski, Johan, Hoebeke, Gilles, Guichard   +4 more
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Lanthanide Reagents in Solid Phase Synthesis

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sloan, Lisa A., Procter, David J.
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Solid-Phase Synthesis of Octapeptin Lipopeptides

2019
Octapeptins are naturally derived cyclic lipopeptide antibiotics with activity against a range of Gram-negative pathogens, including highly resistant strains. Octapeptin C4, an exemplar of the class, was synthesized using a combination of Fmoc solid-phase peptide synthesis (SPPS) and solution-phase cyclization.
Hansford, Karl A., Ziora, Zyta M., Cooper, Matthew A., Blaskovich, Mark A. T.   +3 more
openaire   +5 more sources

Solid-Phase Organometallic Synthesis

Chemistry - A European Journal, 2001
A solid-phase synthesis approach for a class of molybdenum carbonyl complexes has been developed. The system can be used to perform metal-complexation, ligand substitution reactions and oxidative eliminations on the solid phase and to cleave the final complexes under mild and selective conditions.
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Solid Phase Synthesis

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
  +4 more sources

Recent advances in solid-phase synthesis

Molecular Diversity, 1997
The use of solid phase synthesis continues to expand as chemists identify methodology that enables complex reactions. Recent efforts in this area have focused on new carbon-carbon bond forming reactions as well as a variety of heterocyclic systems. These examples are described along with updates on new linking strategies for solid phase synthesis.
openaire   +2 more sources

Solid-Phase Synthesis of Lipidated Peptides

Journal of the American Chemical Society, 2002
Characteristic partial structures of lipidated proteins embodying different lipid groups as well as additional fluorescent tags or a maleimide for coupling to proteins can be synthesized readily by means of a new solid-phase technique employing the oxidative cleavage of the hydrazide linker as well as on-resin farnesylation and palmitoylation after ...
Ludolph, B., Eisele, F., Waldmann, H.
openaire   +3 more sources

Solid-Phase Synthesis of β-Mannosides

Journal of the American Chemical Society, 2002
The linkage of S-phenyl 2,3-di-O-benzyl-alpha-D-thiomannopyranoside to a cross-linked polystyrene support in the form of its 4,6-O-polystyrylborinate ester is described. The activation of this polymer-supported mannosyl donor is achieved at -60 degrees C in dichloromethane in the presence of 2,4,6-tri-tert-butylpyrimidine with the combination 1 ...
David, Crich, Mark, Smith
openaire   +2 more sources

Need for Solid-Phase Thinking in Solid-Phase Synthesis

1973
The invention of the solid-phase method looked like an ingenious trick to overcome some of the unpleasant features of the classical methods. As we know today, the ingenuity of the trick remains, but only a large investment of heavy real effort will eventually, if ever, work it into a real progress over the classical approach.
P. Fankhauser, M. Brenner
openaire   +1 more source