Results 11 to 20 of about 1,533,510 (152)

Formulation and Evaluation of Solid Self-Nanoemulsifying Drug Delivery System of Cannabidiol for Enhanced Solubility and Bioavailability [PDF]

Pharmaceutics
Background/Objectives: This study aims to develop a solid self-nanoemulsifying drug delivery system (SNEDDS) to enhance the solubility and oral bioavailability of cannabidiol (CBD).
Fengying Wu, Qing Ma, Guanghui Tian, Kaixian Chen, Rulei Yang, Jingshan Shen   +5 more
doaj   +3 more sources

Preparation of Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS) by Co-Extrusion of Liquid SNEDDS and Polymeric Carriers—A New and Promising Formulation Approach to Improve the Solubility of Poorly Water-Soluble Drugs [PDF]

Pharmaceuticals, 2022
The present study focused on a new formulation approach to improving the solubility of drugs with poor aqueous solubility. A hot melt extrusion (HME) process was applied to prepare drug-loaded solid self-nanoemulsifying drug delivery systems (S-SNEDDS ...
Fabian-Pascal Schmied, Alexander Bernhardt, Sandra Klein   +2 more
doaj   +2 more sources

Optimization of Glibenclamide Loaded Thermoresponsive SNEDDS Using Design of Experiment Approach: Paving the Way to Enhance Pharmaceutical Applicability [PDF]

Molecules
Thermoresponsive self-nanoemulsifying drug delivery systems (T-SNEDDS) offer a promising solution to the limitations of conventional SNEDDS formulations.
Abdelrahman Y. Sherif, Ehab M. Elzayat, Mohammad A. Altamimi   +2 more
doaj   +3 more sources

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection [PDF]

Nanomaterials, 2021
Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor solubility and permeability, thus leading to the development of intracellular pathogens induced multi-drug resistance and biofilms formation.
Rabia Arshad, Tanveer A. Tabish, Maria Hassan Kiani, Ibrahim M. Ibrahim, Gul Shahnaz, Abbas Rahdar, Misook Kang, Sadanand Pandey   +7 more
doaj   +4 more sources

Orlistat-loaded solid SNEDDS for the enhanced solubility, dissolution, and in vivo performance. [PDF]

Int J Nanomedicine, 2018
Dae Hun Kim,1,* Jae Yeol Kim,1,* Rae Man Kim,1 Pooja Maharjan,1 Yu-Geun Ji,2 Dong-Jin Jang,3 Kyoung Ah Min,1 Tae-Sung Koo,2 Kwan Hyung Cho1 1Department of Pharmacy, Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae ...
Kim DH, Kim JY, Kim RM, Maharjan P, Ji YG, Jang DJ, Min KA, Koo TS, Cho KH.   +8 more
europepmc   +2 more sources

Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution [PDF]

Saudi Pharmaceutical Journal, 2015
A solid self-nanoemulsifying drug-delivery system (solid SNEDDS) has been explored to improve the solubility and dissolution profile of glipizide. SNEDDS preconcentrate was systematically optimized using a circumscribed central composite design by ...
Rajendra Narayan Dash, Habibuddin Mohammed, Touseef Humaira, Devi Ramesh   +3 more
doaj   +2 more sources

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

Molecules, 2020
Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by ...
Mohsin Kazi, Ahmad A. Shahba, Saad Alrashoud, Majed Alwadei, Abdelrahman Y. Sherif, Fars K. Alanazi   +5 more
doaj   +2 more sources

Development and Evaluation of Paclitaxel‐Loaded Self‐Nanoemulsifying Drug Delivery System for Enhanced Cancer Therapy: A Promising Alternative to Cremophor EL–Based Formulation [PDF]

IET Nanobiotechnology, Volume 2026, Issue 1, 2026.
Background and Purpose Paclitaxel’s clinical use is limited by poor aqueous solubility and Cremophor EL–related toxicity in commercial formulations. This study aimed to develop a self‐nanoemulsifying drug delivery system (SNEDDS) to improve paclitaxel solubility, bioavailability, and anticancer efficacy.
Alshaimaa M. Almehmady, Amerh A. Alahmadi, Abrar Hakami, Ehab M. M. Ali, Abdulaziz A. Kalantan, Amjad Aljagthmi, Tarek A. Ahmed, Arul Lenus Roy Vellaisamy   +7 more
wiley   +2 more sources

Solid self-nanoemulsifying cyclosporin A pellets prepared by fluid-bed coating: preparation, characterization and in vitro redispersibility

International Journal of Nanomedicine, 2011
Yang Lei1,2, Yi Lu2, Jianping Qi2, Sufang Nie1, Fuqiang Hu3, Weisan Pan1, Wei Wu21School of Pharmacy, Shenyang Pharmaceutical University, Shenyang; 2School of Pharmacy, Fudan University, Shanghai; 3School of Pharmacy, Zhejiang University, Hangzhou ...
Lei Y, Lu Y, Qi J, Nie S, Hu F, Pan W, Wu W   +6 more
doaj   +1 more source

Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and bioavailability of ezetimibe

International Journal of Nanomedicine, 2015
Rehmana Rashid,1 Dong Wuk Kim,1 Abid Mehmood Yousaf,1 Omer Mustapha,1 Fakhar ud Din,1 Jong Hyuck Park,1 Chul Soon Yong,2 Yu-Kyoung Oh,3 Yu Seok Youn,4 Jong Oh Kim,2 Han-Gon Choi11College of Pharmacy and Institute of Pharmaceutical Science and Technology,
Rashid R, Kim DW, Yousaf AM, Mustapha O, Din FU, Park JH, Yong CS, Oh YK, Youn YS, Kim JO, Choi HG   +10 more
doaj   +1 more source