Results 11 to 20 of about 534,042 (160)

Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14⁺ Monocytes. [PDF]

J Immunol, 2017
Abstract The transmembrane protein CD83, expressed on APCs, B cells, and T cells, can be expressed as a soluble form generated by alternative splice variants and/or by shedding. Soluble CD83 (sCD83) was shown to be involved in negatively regulating the immune response.
Horvatinovich JM, Grogan EW, Norris M, Steinkasserer A, Lemos H, Mellor AL, Tcherepanova IY, Nicolette CA, DeBenedette MA.   +8 more
europepmc   +6 more sources

A Soluble Form of CD83 Is Released From Activated Dendritic Cells and B Lymphocytes, and Is Detectable in Normal Human Sera. [PDF]

International Immunology, 2001
CD83 is an inducible glycoprotein expressed predominantly by dendritic cells (DC) and B lymphocytes. Expression of membrane CD83 (mCD83) is widely used as a marker of differentiated/activated DC but its function and ligand(s) are presently unknown. We report the existence of a soluble form of CD83 (sCD83).
Masato Kato, Derek Hart, J L McKenzie
exaly   +7 more sources

Soluble CD83 ameliorates experimental colitis in mice [PDF]

Mucosal Immunology, 2014
The physiological balance between pro- and anti-inflammatory processes is dysregulated in inflammatory bowel diseases (IBD) as in Crohn's disease and ulcerative colitis. Conventional therapy uses anti-inflammatory and immunosuppressive corticosteroids to treat acute-phase symptoms.
J, Eckhardt, S, Kreiser, M, Döbbeler, C, Nicolette, M A, DeBenedette, I Y, Tcherepanova, C, Ostalecki, A J, Pommer, C, Becker, C, Günther, E, Zinser, T W, Mak, A, Steinkasserer, M, Lechmann   +13 more
openaire   +3 more sources

CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma [PDF]

Haematologica, 2018
Chemotherapy and hematopoietic stem cell transplantation are effective treatments for most Hodgkin lymphoma patients, however there remains a need for better tumor-specific target therapy in Hodgkin lymphoma patients with refractory or relapsed disease ...
Ziduo Li, Xinsheng Ju, Kenneth Lee, Candice Clarke, Jennifer L. Hsu, Edward Abadir, Christian E. Bryant, Suzanne Pears, Neroli Sunderland, Scott Heffernan, Annemarie Hennessy, Tsun-Ho Lo, Geoffrey A. Pietersz, Fiona Kupresanin, Phillip D. Fromm, Pablo A. Silveira, Con Tsonis, Wendy A. Cooper, Ilona Cunningham, Christina Brown, Georgina J. Clark, Derek N.J. Hart   +21 more
doaj   +3 more sources

The CD83 Molecule – An Important Immune Checkpoint

Frontiers in Immunology, 2020
The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils.
Linda Grosche, Ilka Knippertz, Christina König, Dmytro Royzman, Andreas B. Wild, Elisabeth Zinser, Heinrich Sticht, Yves A. Muller, Alexander Steinkasserer, Matthias Lechmann   +9 more
doaj   +2 more sources

Prevention and treatment of experimental autoimmune encephalomyelitis by soluble CD83. [PDF]

J Exp Med, 2004
CD83 is up-regulated on the surface of dendritic cells (DCs) during maturation and has been widely used as a marker for mature DCs. Recently, we reported the recombinant expression of the extracellular immunoglobulin domain of human CD83 (hCD83ext). Using this soluble form of CD83, allogeneic as well as specific cytotoxic T lymphocyte proliferation ...
Zinser E, Lechmann M, Golka A, Lutz MB, Steinkasserer A.   +4 more
europepmc   +4 more sources

Molecular cloning and characterization of duck CD83 and its effect on H9N2 avian influenza virus replication. [PDF]

Poult Sci
Cluster of Differentiation 83 (CD83) is a multifunctional regulatory molecule that has been identified in several mammals, birds, and fishes; however, no reports have described CD83 in ducks to date.
Li H, Xin X, Yin Z, Dong C, Li F, Liu Y, Kong X, Wang L, Wang J, Yu F, Huo S.   +10 more
europepmc   +2 more sources

A Kinetic Study of CD83 Reveals an Upregulation and Higher Production of sCD83 in Lymphocytes from Pregnant Mice [PDF]

Frontiers in Immunology, 2017
For the normal development of pregnancy, a balance between immune tolerance and defense is crucial. However, the mechanisms mediating such a balance are not fully understood.
Damián Oscar Muzzio, Katrin Regina Helene Packhäuser, Gleyder Roman-Sosa, Jens Ehrhardt, Diana Krüger, Marek Zygmunt   +5 more
doaj   +2 more sources

The Soluble Form of CD83 Dramatically Changes the Cytoskeleton of Dendritic Cells

Immunobiology, 2004
CD83 is the best-known surface marker for mature dendritic cells (DC) and recently we could show that a soluble form of CD83 inhibits DC maturation. In addition, this soluble form inhibits DC-mediated T cell proliferation in vitro and in vivo. Furthermore, several viruses induce CD83 degradation or shedding in infected DC.
Alexander Steinkasserer, Matthias Lechmann   +1 more
exaly   +3 more sources

Pregnancy-related factors induce immune tolerance through regulation of sCD83 release. [PDF]

Front Immunol
A well-balanced maternal immune system is crucial to maintain fetal tolerance in case of infections during pregnancy. Immune adaptations include an increased secretion of soluble mediators to protect the semi-allogeneic fetus from excessive pro ...
Krupa P, Wein H, Zemmrich LS, Zygmunt M, Muzzio DO.   +4 more
europepmc   +2 more sources