Results 31 to 40 of about 10,033 (176)

Direct Activation of Human Dendritic Cells by Particle-Bound but Not Soluble MHC Class II Ligand [PDF]

, 2013
Dendritic cells (DCs) are key activators of cellular immune responses through their capacity to induce naïve T cells and sustained effector T cell responses. This capacity is a function of their superior efficiency of antigen presentation via MHC class I
Baleeiro, R.B. (Renato), Barbuto, J.A. (José), Dähne, L. (Lars), Lademann, J. (Jürgen), Walden, P. (Peter), Wiesmüller, K.H. (Karl Heinz)   +5 more
core   +1 more source

Expression of chicken DEC205 reflects the unique structure and function of the avian immune system [PDF]

, 2013
The generation of appropriate adaptive immune responses relies critically on dendritic cells, about which relatively little is known in chickens, a vital livestock species, in comparison with man and mouse. We cloned and sequenced chicken DEC205 cDNA and
Butter, Colin, Staines, Karen, Young, John R.   +2 more
core   +11 more sources

DENDRITIC CELL DIFFERENTIATION BLOCKED BY PRIMARY EFFUSION LYMPHOMA-RELEASED FACTORS IS PARTIALLY RESTORED BY INHIBITION OF P38 MAPK [PDF]

, 2010
To better understand the molecular mechanisms underlying the dendritic cell (DC) defects in cancer, we analyzed which signaling pathway is implicated in the abnormal monocyte differentiation into DC determined by the presence of Primary effusion lymphoma
CIRONE, Mara, DI RENZO, Livia Maria, FAGGIONI, Alberto, FRATI, Luigi, G. Borgia, G. Lucania, TRIVEDI, PANKAJ   +6 more
core   +2 more sources

A Kinetic Study of CD83 Reveals an Upregulation and Higher Production of sCD83 in Lymphocytes from Pregnant Mice

Frontiers in Immunology, 2017
For the normal development of pregnancy, a balance between immune tolerance and defense is crucial. However, the mechanisms mediating such a balance are not fully understood.
Damián Oscar Muzzio, Katrin Regina Helene Packhäuser, Gleyder Roman-Sosa, Jens Ehrhardt, Diana Krüger, Marek Zygmunt   +5 more
doaj   +1 more source

Tumor derived Microvesicles enhance cross-processing ability of clinical grade Dendritic Cells [PDF]

, 2018
Tumor cells release extracellular microvesicles (MVs) in the microenvironment to deliver biological signals to neighbouring cells as well as to cells in distant tissues.
Battisti, Federico, Belleudi, Francesca, Claudia De Archangelis,, DI FILIPPO, Alessandra, Dionisi, Marco, Napoletano, Chiara, Nuti, Marianna, RAHIMI KOSHKAKI, Hassan, Rughetti, Aurelia, Ruscito, Ilary, Torrisi, Maria Rosaria, Zizzari, ILARIA GRAZIA   +11 more
core   +1 more source

An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases

Frontiers in Immunology, 2018
Many neurologic diseases are related to autoimmune dysfunction and a variety of molecules or reaction pathways are involved in the regulation of immune function of the nervous system. Soluble CD83 (sCD83) is the soluble form of CD83, a specific marker of
Li Bo, Tan Guojun, Guo Li
doaj   +1 more source

CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells [PDF]

, 2012
CD40L has a well-established role in enhancing the immunostimulatory capacity of normal and malignant B cells, but a formulation suitable for clinical use has not been widely available.
Ahove, Deborah, Alonso, Anselmo, Burkhardt, Ute E., Duke-Cohan, Jonathan S., Freeman, Gordon James, Fu, Buyin, Hainz, Ursula, Matsuoka, Ken-ichi, Naito, Masayasu, Neuberg, Donna, Rajasagi, Mohini, Stevenson, Kristen E., Witten, Elizabeth, Wu, Cathy Ju-Ying, Zhu, Baogong   +14 more
core   +1 more source

Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells

Frontiers in Immunology, 2019
The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation.
Elisabeth Zinser, Ronald Naumann, Andreas B. Wild, Julia Michalski, Andrea Deinzer, Lena Stich, Christine Kuhnt, Alexander Steinkasserer, Ilka Knippertz   +8 more
doaj   +1 more source

Immunomodulatory effects of heat killed 'Mycobacterium obuense' on human blood dendritic cells [PDF]

, 2017
Heat-killed (HK) Mycobacterium obuense is a novel immunomodulator, currently undergoing clinical evaluation as an immunotherapeutic agent in the treatment of cancer. Here, we examined the effect of in vitro exposure to HK M. obuense on the expression of
Achkar, Marcel, Akle, Charles, Bahr, Georges, Bazzi, Samer, Modjtahedi, Helmout, Mudan, Satvinder   +5 more
core   +1 more source

Involvement of Caveolin-1 in CD83 Internalization in Mouse Dendritic Cells

Cell Transplantation, 2015
To become potent T-cell stimulators, DCs need to mature. Treatment with soluble CD83 (sCD83) induces immune tolerance and protects against transplant rejection by maintaining dendritic cells in an immature, tolerogenic state.
Yuejing Yang, Zhongcheng Xin, Jingjia Chu, Na Li, Tao Sun M.D., Ph.D.   +4 more
doaj   +1 more source