Results 31 to 40 of about 534,042 (160)

CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential

Frontiers in Immunology, 2019
CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic
Ziduo Li, Ziduo Li, Xinsheng Ju, Xinsheng Ju, Pablo A. Silveira, Pablo A. Silveira, Edward Abadir, Edward Abadir, Wei-Hsun Hsu, Wei-Hsun Hsu, Derek N. J. Hart, Derek N. J. Hart, Georgina J. Clark, Georgina J. Clark   +13 more
doaj   +1 more source

Alternative Splicing Generates Putative Soluble CD83 Proteins That Inhibit T Cell Proliferation [PDF]

The Journal of Immunology, 2005
Abstract CD83 is expressed on mature dendritic cells and activated lymphocytes and has been implicated to play an important role during T cell development in the thymus. In contrast, not much is known about the function of CD83 in the periphery.
Diana, Dudziak, Falk, Nimmerjahn, Georg W, Bornkamm, Gerhard, Laux   +3 more
openaire   +2 more sources

CD83 Regulates the Immune Responses in Inflammatory Disorders

, 2023
Activating the immune system plays an important role in maintaining physiological homeostasis and defending the body against harmful infections. However, abnormalities in the immune response can lead to various immunopathological responses and severe ...
Islam, SMS, Riaz, B, Sohn, S, Seonghyang Sohn, Hye Ryu, Ryu, HM, Bushra Riaz, S. Islam   +7 more
core   +1 more source

Human T-cell leukemia virus type-I Tax induces the expression of CD83 on T cells [PDF]

, 2015
Background: CD83, a cell surface glycoprotein that is stably expressed on mature dendritic cells, can be transiently induced on other hematopoietic cell lineages upon cell activation.
Mariko Mizuguchi, Tanaka, Reiko, Mizuguchi, Mariko, Yuetsu Tanaka, Takuya Fukushima, Yoshiaki Takahashi, Takeaki Tomoyose, Ansari, Aftab A, Takahashi, Yoshiaki, Masataka Nakamura, Fukushima, Takuya, Tanaka, Yuetsu, Nakamura, Masataka, Tomoyose, Takeaki, Hideki Fujii, Aftab A Ansari, Reiko Tanaka, Fujii, Hideki   +17 more
core   +1 more source

An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases

Frontiers in Immunology, 2018
Many neurologic diseases are related to autoimmune dysfunction and a variety of molecules or reaction pathways are involved in the regulation of immune function of the nervous system. Soluble CD83 (sCD83) is the soluble form of CD83, a specific marker of
Li Bo, Tan Guojun, Guo Li
doaj   +1 more source

Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells

Frontiers in Immunology, 2019
The CD83 is a type I membrane protein and part of the immunoglobulin superfamily of receptors. CD83 is involved in the regulation of antigen presentation and dendritic cell dependent allogeneic T cell proliferation.
Elisabeth Zinser, Ronald Naumann, Andreas B. Wild, Julia Michalski, Andrea Deinzer, Lena Stich, Christine Kuhnt, Alexander Steinkasserer, Ilka Knippertz   +8 more
doaj   +1 more source

Involvement of Caveolin-1 in CD83 Internalization in Mouse Dendritic Cells

Cell Transplantation, 2015
To become potent T-cell stimulators, DCs need to mature. Treatment with soluble CD83 (sCD83) induces immune tolerance and protects against transplant rejection by maintaining dendritic cells in an immature, tolerogenic state.
Yuejing Yang, Zhongcheng Xin, Jingjia Chu, Na Li, Tao Sun M.D., Ph.D.   +4 more
doaj   +1 more source

Soluble human CD83 ameliorates lupus in NZB/W F1 mice

Immunobiology, 2013
In the present study we explored the immunomodulatory potential of prokaryotically expressed soluble CD83 in the treatment of murine lupus using the NZB/W F1 mouse model. Therefore female NZB/W F1 lupus mice were treated either with sCD83 or PBS for 4 weeks.
Starke, Charlotte, Steinkasserer, Alexander, Voll, Reinhard E., Zinser, Elisabeth   +3 more
openaire   +3 more sources

Development of an adjuvanted nanoparticle vaccine against influenza virus, an in vitro study.

PLoS ONE, 2020
Influenza is an infectious respiratory illness caused by influenza viruses. Despite yearly updates, the efficacy of influenza vaccines is significantly curtailed by the virus antigenic drift and antigenic shift.
Kamonthip Rungrojcharoenkit, Panya Sunintaboon, Damon Ellison, Louis Macareo, Panuwat Midoeng, Preamrudee Chaisuwirat, Stefan Fernandez, Sukathida Ubol   +7 more
doaj   +1 more source

Shed GP of Ebola virus triggers immune activation and increased vascular permeability. [PDF]

PLoS Pathogens, 2014
During Ebola virus (EBOV) infection a significant amount of surface glycoprotein GP is shed from infected cells in a soluble form due to cleavage by cellular metalloprotease TACE.
Beatriz Escudero-Pérez, Valentina A Volchkova, Olga Dolnik, Philip Lawrence, Viktor E Volchkov   +4 more
doaj   +1 more source