Results 51 to 60 of about 10,033 (176)

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help [PDF]

, 2017
Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone (DZ), and in the latter they proliferate and hypermutate their immunoglobulin genes. How this functional transition takes place is still controversial.
Allen, Bannard, Bonifaz, Boscardin, Calado, Chambers, Chie Kawai, Dansen, De Silva, Dominguez-Sola, Dominguez-Sola, Dorsey, Draghi, Dubrovska, Gitlin, Gitlin, Gong, Hedrick, Huang, Inoue, Ise, Itano, Kitamura, Kurosaki, Kuwahara, Liu, Murphy, Murphy, Paik, Pape, Rickert, Ryo Shinnakasu, Safford, Sagardoy, Sander, Schwickert, Shih, Shinnakasu, Shlomchik, Subramanian, Takeshi Egawa, Takeshi Inoue, Taylor, Toellner, Tomohiro Kurosaki, Trinh, Victora, Victora, Victora, Victora, Wataru Ise, Zhang, Zheng   +52 more
core   +2 more sources

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Immunomodulatory effects of human umbilical cord wharton's Jelly-Derived mesenchymal stem cells on differentiation, maturation and endocytosis of monocyte-derived dendritic cells [PDF]

, 2013
The Wharton's jelly of the umbilical cord is believed to be a source of mesenchymal stem cells (MSCs) which can be therapeutically applied in degenerative diseases.
Bonab, M.M., Hadjati, J., Latifpour, M., Masoud, A., Nicknam, M.H., Nikbin, B., Saeidi, M., Shakiba, Y.   +7 more
core  

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34+ progenitor cells during differentiation into antigen presenting cells [PDF]

, 2001
The inducible costimulator receptor (ICOS) is a third member of the CD28 receptor family that regulates T cell activation and function. ICOS binds to a newly identified ligand on antigen presenting cells different from the CD152 ligands CD80 and CD86. We
Aicher, A, Clark, EA, Daemen, K, Hayden-Ledbetter, M, Irgang, M, Korner, I, Ledbetter, JA, Pezzutto, A, Richter, G, Westermann, J   +9 more
core  

Topical Application of Soluble CD83 Induces IDO-Mediated Immune Modulation, Increases Foxp3+ T Cells, and Prolongs Allogeneic Corneal Graft Survival [PDF]

The Journal of Immunology, 2013
Abstract Modulation of immune responses is one of the main research aims in transplant immunology. In this study, we investigate the local immunomodulatory properties of soluble CD83 (sCD83) at the graft-host interface using the high-risk corneal transplantation model.
Felix Bock, Susanne Rössner, Jasmine Onderka, Matthias Lechmann, PALLOTTA, MARIA TERESA, FALLARINO, Francesca, Louis Boon, Charles Nicolette, Mark A. DeBenedette, Irina Y. Tcherepanova, GROHMANN, Ursula, Alexander Steinkasserer, Claus Cursiefen, Elisabeth Zinser   +13 more
openaire   +3 more sources

Direct contact of platelets and their released products exert different effects on human dendritic cell maturation

BMC Immunology, 2008
Background Dendritic cells (DCs) are antigen presenting cells capable of inducing innate and adaptive immune responses. According to the stimulus and their maturation state, DCs induce immunogenic or tolerogenic responses.
Delézay Olivier, Olivier Thomas, Chavarin Patricia, Palle Sabine, Cognasse Fabrice, Hamzeh-Cognasse Hind, Pozzetto Bruno, Garraud Olivier   +7 more
doaj   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Tumor-Infiltrating γδ T Cells Suppress T and Dendritic Cell Function via Mechanisms Controlled by a Unique Toll-like Receptor Signaling Pathway [PDF]

, 2007
Summaryγδ T cells are important contributors to innate immunity against cancer, but their regulatory role in controlling immune responses remains largely unknown.
Guangyong Peng, Helen Y. Wang, Weiyi Peng, Yukiko Kiniwa, Kook Heon Seo, Rong-Fu Wang, Akira, Bauer, Boismenu, Brenner, Bukowski, Choudhary, Constant, Crellin, Curiel, Diefenbach, Dunn, Eberl, Girardi, Groh, Groh, Havran, Hayday, Hayday, Huang, Huang, Jameson, Jameson, Jurk, Kabelitz, Liu, Liyanage, Modlin, Okita, Pasare, Peng, Pennington, Pennington, Qin, Rosenberg, Sakaguchi, Sato, Sato, Shevach, Shin, Sutmuller, Sutmuller, Wan, Wang, Wang, Wang, Wang, Wang, Woo   +53 more
core   +6 more sources

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source