Results 51 to 60 of about 534,042 (160)
Abstract INTRODUCTION Late‐onset Alzheimer's disease (LOAD) and major depressive disorder (MDD) share genetic etiologies. Here, we investigated brain transcriptomic landscapes to gain insights into shared and divergent molecular and biological etiologies across LOAD and MDD.
Michael W. Lutz +2 more
wiley +1 more source
Abstract Waldenström macroglobulinemia (WM) and IgM monoclonal gammopathy of undetermined significance (MGUS) share the same cell of origin but differ in clonal size. Compared with other B‐cell neoplasms, the lymphoplasmacytic clone in WM can be rather small, limiting our understanding of clonal expansion.
David F. Moreno +22 more
wiley +1 more source
New Role of P. brasiliensis α-Glucan: Differentiation of Non-conventional Dendritic Cells
The cell wall has a critical role in the host immune response to fungal pathogens. In this study, we investigated the influence of two cell wall fractions of the dimorphic fungi Paracoccidioides brasiliensis (Pb) in the in vitro generation of monocyte ...
Ana Camila Oliveira Souza +9 more
doaj +1 more source
Targeted proteomics reveal histiocytosis‐associated neurodegeneration signatures
Abstract Neurodegeneration (ND) is a severe complication of Langerhans cell histiocytosis (LCH), yet its underlying biology and reliable biomarkers remain poorly defined. The aim of this study was to (1) gain insight into neuroimmunological mechanisms governing ND and (2) assess the clinical value of established and novel biomarkers for ND‐LCH.
Egle Kvedaraite +29 more
wiley +1 more source
Applications of Mesenchymal Stromal Cells for Treatment of Diseases
This schematic summarizes the major therapeutic mechanisms of MSCs across different disease systems and highlights factors associated with MSCs dysfunction, together with current strategies to enhance MSCs function and therapeutic efficacy. This summary diagram illustrates that MSCs exert therapeutic effects in various diseases through multiple ...
Dongmei Xue, Yongsheng Li, Lei Wu
wiley +1 more source
The n−3 fatty acids are not produced by mammals, although they are essential for hormone synthesis and maintenance of cell membrane structure and integrity.
Éva Rajnavölgyi +4 more
doaj +1 more source
Background Soluble fibrinogen-like protein 2 (sFGL2), a secretory protein expressed by regulatory T cells (Tregs) with immunosuppressive activity, is highly expressed in both the peripheral blood and tumor tissue of patients with hepatocellular carcinoma
Muyang Yang +11 more
doaj +1 more source
Extracellular vesicles at the nexus of skin cancer progression and precision therapy. EVs orchestrate tumor microenvironment remodeling through cargo‐mediated intercellular communication, immune modulation, angiogenesis, and extracellular matrix reorganization, while also emerging as next‐generation platforms for targeted drug delivery, biomarker ...
Megha Kotian +7 more
wiley +1 more source
Spender-induzierte Transplantattoleranz durch CD83 nach Hornhauttransplantation [PDF]
The CD83 molecule is a powerful immunomodulatory protein which contributes to the resolution of inflammation. Expression of CD83 is a hallmark of mature dendritic cells (DCs), but this molecule is also expressed on other activated immune cells including ...
Peckert-Maier, Katrin
core
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley +1 more source

