Results 61 to 70 of about 10,033 (176)

Composition and Surface Charge of DNA-Loaded Microparticles Determine Maturation and Cytokine Secretion in Human Dendritic Cells [PDF]

, 2018
Purpose. Biodegradable microparticles prepared from poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) have been shown to be promising carrier systems for vaccine delivery.
Jilek, Samantha, Merkle, Hans, Ulrich, Michael, Walter, Elke   +3 more
core  

Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study [PDF]

, 2015
International audienceAbstractIn human lung fibrotic lesions, fibroblasts were shown to be closely associated with immature dendritic cell (DC) accumulation.
Crestani, Bruno, Freynet, Olivia, Jean-Louis, Francette, Mailleux, Arnaud, Marchal-Sommé, Joëlle, Michel, Laurence, Soler, Paul   +6 more
core   +4 more sources

Age‐related differences in mRNA vaccine immunogenicity and adjuvancy

Immunology &Cell Biology, Volume 104, Issue 4, Page 400-414, April 2026.
Older people often respond poorly to mRNA vaccines, with reduced T and B cell responses, but they also bear more morbidity and mortality for infectious diseases. This paper maps age‐related changes in mechanisms of adjuvancy that can shape the immunogenicity of mRNA vaccine in a mouse model. Created in BioRender.
Shivali Savita Chinni, Gemma S Trollope, Patrick Leung, Jonathan L McQualter, Chee Wah Tan, Linfa Wang, Leonard Lim, Adam K Wheatley, Jennifer A Juno, Stephen J Kent, Hareth A Al‐Wassiti, Colin W Pouton, Kylie M Quinn   +12 more
wiley   +1 more source

New Role of P. brasiliensis α-Glucan: Differentiation of Non-conventional Dendritic Cells

Frontiers in Microbiology, 2019
The cell wall has a critical role in the host immune response to fungal pathogens. In this study, we investigated the influence of two cell wall fractions of the dimorphic fungi Paracoccidioides brasiliensis (Pb) in the in vitro generation of monocyte ...
Ana Camila Oliveira Souza, Cecília Favali, Naiara Caroline Soares, Natalia Machado Tavares, Márcio Sousa Jerônimo, Paulo Henrique Veloso Junior, Clara Luna Marina, Claire Santos, Cláudia Brodskyn, Anamelia Lorenzetti Bocca   +9 more
doaj   +1 more source

Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and vasoprotective effects. This review aims to provide a comprehensive overview of LEO's pharmacokinetics, pharmacological mechanisms ...
Zhouyue Gu
wiley   +1 more source

Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials [PDF]

, 2011
Background For clinical applications, dendritic cells (DCs) need to be generated using GMP-approved reagents. In this study, we tested the characteristics of DCs generated in two clinical grade culture media and activated by three maturation stimuli ...
Jitka Fučíková, Daniela Rožková, Hana Ulčová, Vít Budinský, Klára Sochorová, Kateřina Pokorná, Jiřina Bartůňková, Radek Špíšek   +7 more
core   +1 more source

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan, Maija Corey, Alicia Gibbons, Mahati Rayadurgam, Neha Reddy, Pavithra Ramesh, Sonia Sharma   +6 more
wiley   +1 more source

Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer [PDF]

, 2007
The generation of antitumour immunity depends on the nature of dendritic cell (DC)-tumour interactions. These have been studied mostly by using in vitro-derived DC which may not reflect the natural biology of DC in vivo. In breast cancer, only one report
A Pinzon-Charry, A Pinzon-Charry, A Pinzon-Charry, A Pinzon-Charry, A Pinzon-Charry, A Pinzon-Charry, A Pinzon-Charry, AE Papatestas, AK Bengtsson, B Almand, B Berghofer, BJ Coventry, C Furnival, C M Pyke, C Menetrier-Caux, C S K Ho, C Schmidt, CA Savary, CC Sombroek, CS Ho, CS Ho, D Bell, DI Gabrilovich, DI Gabrilovich, F Sallusto, G Nalbandian, GJ Randolph, H Jonuleit, ID Davis, J A López, J Banchereau, J Komi, J Komi, J Peguet-Navarro, L Lespagnard, LH Sobin, M A McGuckin, M Cella, M Ratta, MW Onaitis, NA Zeid, P Lissoni, P Terheyden, R Thomas, R Thomas, S Della Bella, S Markowicz, S Satthaporn, SP Robinson, T Maxwell, TK Hoffmann, W Janni   +51 more
core   +2 more sources

Soluble CD83 Accelerates Wound Healing and Attenuates Inflammatory Responses Induced by Chronic Wound Fluid in a Human 3D in Vitro Wound Healing Model

Wound Repair and Regeneration, Volume 34, Issue 2, March/April 2026.
ABSTRACT Chronic wounds, as defined by prolonged inflammation and impaired healing, represent a major and growing healthcare challenge worldwide. Currently, only limited therapeutic options are available to address this condition. This study investigates the potential of soluble CD83 (sCD83), an immunomodulatory molecule, to facilitate wound healing in
Christian Hollard, Katrin Peckert‐Maier, Moritz Ronicke, Pia Sinner, Fabian Stritt, Tobias Spöttl, Petra Mühl‐Zürbes, Stefan Wirtz, Cornelia Erfurt‐Berge, Alexander Steinkasserer, Dmytro Royzman   +10 more
wiley   +1 more source

FOXP3 and GARP (LRRC32): the master and its minion [PDF]

, 2010
The transcription factor FOXP3 is essential for the development and function of CD4+CD25hiFOXP3+ regulatory T (Treg) cells, but also expressed in activated human helper T cells without acquisition of a regulatory phenotype.
Michael Probst-Kepper, Jan Buer
core   +1 more source