Results 71 to 80 of about 10,033 (176)

Effects of RAMEA-complexed polyunsaturated fatty acids on the response of human dendritic cells to inflammatory signals

Beilstein Journal of Organic Chemistry, 2014
The n−3 fatty acids are not produced by mammals, although they are essential for hormone synthesis and maintenance of cell membrane structure and integrity.
Éva Rajnavölgyi, Renáta Laczik, Viktor Kun, Lajos Szente, Éva Fenyvesi   +4 more
doaj   +1 more source

Soluble fibrinogen-like protein 2 promotes the growth of hepatocellular carcinoma via attenuating dendritic cell-mediated cytotoxic T cell activity

Journal of Experimental & Clinical Cancer Research, 2019
Background Soluble fibrinogen-like protein 2 (sFGL2), a secretory protein expressed by regulatory T cells (Tregs) with immunosuppressive activity, is highly expressed in both the peripheral blood and tumor tissue of patients with hepatocellular carcinoma
Muyang Yang, Zhongwei Zhang, Jiajia Chen, Mengying Xu, Jiaquan Huang, Ming Wang, Weina Li, Xiaoyang Wan, Man-Fung Yuen, Xiaoping Luo, Dong Xi, Qin Ning   +11 more
doaj   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, Volume 15, Issue 8, 23 February 2026.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Human breast cancer-derived soluble factors facilitate CCL19-induced chemotaxis of human dendritic cells [PDF]

, 2016
Breast cancer remains as a challenging disease with high mortality in women. Increasing evidence points the importance of understanding a crosstalk between breast cancers and immune cells, but little is known about the effect of breast cancer-derived ...
A Lin, A MartIn-Fontecha, A Pinzon-Charry, AG Pantschenko, B Almand, B Weigelt, BG Ricart, BJ Coventry, BL Pierce, C Huang, C Sautes-Fridman, D Bell, D Gabrilovich, DF Quail, DG DeNardo, EF Wagner, F Pages, GJ Zhang, H Hwang, H Hwang, H Matsushita, I Treilleux, J Banchereau, J Crespo, JG Cyster, K Omori, K Wojas, KC Sheng, L Lespagnard, L Riol-Blanco, LM Coussens, MT Lotze, N Iijima, P Radwan, QL Liu, RM Steinman, RM Steinman, RM Steinman, S Della Bella, S Satthaporn, S Wang, SI Grivennikov, SP Kerkar, U Haessler, U Oltmanns, W Zou, Y Ma, ZC Hartman   +47 more
core   +1 more source

HLA‐DRB1 Allelic Combinations Differentially Shape Dendritic Cell Antigen Presentation Enhanced by Tumour Cell Line Lysate‐Pulsing

HLA, Volume 107, Issue 2, February 2026.
ABSTRACT The anti‐tumour immune response plays a pivotal role in eliminating tumour cells, with the presence of tumour‐infiltrating lymphocytes (TILs) often correlated with improved patient outcomes. Among these, CD4+ T lymphocytes act as key orchestrators of the immune response, functioning as effector and regulatory cells, and are essential for ...
Gonzalo Lázaro, Juan A. Cedano, Maitane Faus, Carme Roura‐Mir, Laia Garrigós, José Pérez‐García, Javier Román‐García, Javier Cortés, Andrea Aran, Mercè Martí   +9 more
wiley   +1 more source

Vibrio cholerae ghosts (VCG) exert immunomodulatory effect on dendritic cells for enhanced antigen presentation and induction of protective immunity [PDF]

, 2014
BACKGROUND: We previously showed that the Vibrio cholerae ghost platform (VCG; empty V. cholerae cell envelopes) is an effective delivery system for vaccine antigens promoting the induction of substantial immunity in the absence of external adjuvants ...
Arieian Johnson, Carolyn M Black, Cheng He, Chris Ibegbu, Daniel M N Okenu, Francis O Eko, Jayanti Mania-Pramanik, Joseph U Igietseme, Qing He, Qing Pan, Raedeen Russell, Roshan Pais   +11 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Mesenchymal stem cells derived from human exfoliated deciduous teeth (SHEDs) induce immune modulatory profile in monocyte-derived dendritic cells.

PLoS ONE, 2014
BackgroundMesenchymal stem cells have prominent immune modulatory properties, which may have clinical applications; however their major source, bone marrow, is of limited availability.
Fernando de Sá Silva, Rodrigo Nalio Ramos, Danilo Candido de Almeida, Enio Jose Bassi, Roberto Pereira Gonzales, Sueli Patricia Harumi Miyagi, Claudinéia Pereira Maranduba, Osvaldo Augusto Brazil Esteves Sant'Anna, Márcia Martins Marques, José Alexandre Marzagão Barbuto, Niels Olsen Saraiva Câmara, Carlos Magno da Costa Maranduba   +11 more
doaj   +1 more source

Pro‐Inflammatory c‐Met+ CD4 T Cells in Multiple Sclerosis

Annals of Neurology, Volume 99, Issue 1, Page 261-273, January 2026.
Objective Hepatocyte growth factor (HGF) binds exclusively the c‐Met surface receptor, and the HGF/c‐Met axis regulates T cell function in autoimmune diseases. We analyzed c‐Met expression on human CD4 T cells in the blood and cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) versus non‐inflammatory neurological disease (NIND), to ...
Gautier Breville, Mahdia Benkhoucha, Ayman Rezk, Ngoc Lan Tran, Isis Senoner, Amit Bar‐Or, Patrice H. Lalive   +6 more
wiley   +1 more source

Dendritic-Cell (DC)-Based Immunotherapy: Tumor Endothelial Marker 8 (TEM8) Gene Expression of DC Vaccines Correlates with Clinical Outcome [PDF]

, 2008
\ud Previous studies have shown that tumor-endothelial markers (TEMs) are upregulated in immunosuppressive, pro-angiogenic dendritic cells (DCs) found in tumor microenvironments. \ud We reported that pro-angiogenic monocyte-derived DCs (Mo-DCs), utilized
Bolli, Elisabetta, Ridolfi, R., Venanzi, F.M.   +2 more
core