Results 21 to 30 of about 10,033 (176)

A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera [PDF]

International Immunology, 2001
CD83 is an inducible glycoprotein expressed predominantly by dendritic cells (DC) and B lymphocytes. Expression of membrane CD83 (mCD83) is widely used as a marker of differentiated/activated DC but its function and ligand(s) are presently unknown. We report the existence of a soluble form of CD83 (sCD83).
Hock, BD, Kato, M, McKenzie, JL, Hart, DNJ   +3 more
openaire   +5 more sources

Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property. [PDF]

Int J Biol Sci, 2020
Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in the alleviation of experimental AR.
Wu YJ, Song YN, Geng XR, Ma F, Mo LH, Zhang XW, Liu DB, Liu ZG, Yang PC.   +8 more
europepmc   +4 more sources

Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14⁺ Monocytes. [PDF]

J Immunol, 2017
AbstractThe transmembrane protein CD83, expressed on APCs, B cells, and T cells, can be expressed as a soluble form generated by alternative splice variants and/or by shedding. Soluble CD83 (sCD83) was shown to be involved in negatively regulating the immune response.
Horvatinovich JM, Grogan EW, Norris M, Steinkasserer A, Lemos H, Mellor AL, Tcherepanova IY, Nicolette CA, DeBenedette MA.   +8 more
europepmc   +5 more sources

Soluble CD83 ameliorates experimental colitis in mice [PDF]

Mucosal Immunology, 2014
The physiological balance between pro- and anti-inflammatory processes is dysregulated in inflammatory bowel diseases (IBD) as in Crohn's disease and ulcerative colitis. Conventional therapy uses anti-inflammatory and immunosuppressive corticosteroids to treat acute-phase symptoms.
J, Eckhardt, S, Kreiser, M, Döbbeler, C, Nicolette, M A, DeBenedette, I Y, Tcherepanova, C, Ostalecki, A J, Pommer, C, Becker, C, Günther, E, Zinser, T W, Mak, A, Steinkasserer, M, Lechmann   +13 more
openaire   +2 more sources

Alternative Splicing Generates Putative Soluble CD83 Proteins That Inhibit T Cell Proliferation [PDF]

The Journal of Immunology, 2005
Abstract CD83 is expressed on mature dendritic cells and activated lymphocytes and has been implicated to play an important role during T cell development in the thymus. In contrast, not much is known about the function of CD83 in the periphery.
Diana, Dudziak, Falk, Nimmerjahn, Georg W, Bornkamm, Gerhard, Laux   +3 more
openaire   +2 more sources

Nsp1α of Porcine Reproductive and Respiratory Syndrome Virus Strain BB0907 Impairs the Function of Monocyte-Derived Dendritic Cells via the Release of Soluble CD83. [PDF]

J Virol, 2018
ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV), a virulent pathogen of swine, suppresses the innate immune response and induces persistent infection. One mechanism used by viruses to evade the immune system is to cripple the antigen-processing machinery in monocyte-derived dendritic cells (MoDCs).
Chen X, Bai J, Liu X, Song Z, Zhang Q, Wang X, Jiang P.   +6 more
europepmc   +4 more sources

Porcine Reproductive and Respiratory Syndrome Virus Modulates the Switch of Macrophage Polarization from M1 to M2 by Upregulating MoDC-Released sCD83

Viruses, 2023
Porcine reproductive and respiratory syndrome virus (PRRSV), the most economically important infectious disease of pigs, elicits poor innate and adaptive immune responses. Soluble CD83 (sCD83), a secretion from various immune cell populations, especially
Xingyu Gong, Tianyi Ma, Qiaoya Zhang, Yanhong Wang, Chengchuang Song, Min Lai, Chunlei Zhang, Xingtang Fang, Xi Chen   +8 more
doaj   +1 more source

CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma

Haematologica, 2018
Chemotherapy and hematopoietic stem cell transplantation are effective treatments for most Hodgkin lymphoma patients, however there remains a need for better tumor-specific target therapy in Hodgkin lymphoma patients with refractory or relapsed disease ...
Ziduo Li, Xinsheng Ju, Kenneth Lee, Candice Clarke, Jennifer L. Hsu, Edward Abadir, Christian E. Bryant, Suzanne Pears, Neroli Sunderland, Scott Heffernan, Annemarie Hennessy, Tsun-Ho Lo, Geoffrey A. Pietersz, Fiona Kupresanin, Phillip D. Fromm, Pablo A. Silveira, Con Tsonis, Wendy A. Cooper, Ilona Cunningham, Christina Brown, Georgina J. Clark, Derek N.J. Hart   +21 more
doaj   +1 more source

Anisakis pegreffii impacts differentiation and function of human dendritic cells [PDF]

, 2018
Human dendritic cells (DCs) show remarkably phenotypic changes when matured in presence of helminth-derived products. These modifications frequently elicited a polarization towards Th2 cells and regulatory T cells thus contributing to immunological ...
Allen, Alonso-Gómez, Annunziato, Aranzamendi, Babal, Baeza, Battisti, Becher, Blanco, Coakley, Cortés, Cvetkovic, D'Amelio, Das Mohapatra, Daschner, Dowling, Entwistle, Gerbe, Giri, Gruden-Movsesijan, Hall, Hartmann, Hiemstra, Iborra, Ivanova, Johnson, Klaver, Kotsias, Kuijk, Lian, Lim, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Messina, Mladineo, Morris, Motran, Nakahara, Nieuwenhuizen, Pulendran, Rescigno, Rodríguez, Rughetti, Silva, Swofford, Terrazas, Ueno, Umehara, Witkowska, Zizzari   +55 more
core   +1 more source

Soluble human CD83 ameliorates lupus in NZB/W F1 mice

Immunobiology, 2013
In the present study we explored the immunomodulatory potential of prokaryotically expressed soluble CD83 in the treatment of murine lupus using the NZB/W F1 mouse model. Therefore female NZB/W F1 lupus mice were treated either with sCD83 or PBS for 4 weeks.
Starke, Charlotte, Steinkasserer, Alexander, Voll, Reinhard E., Zinser, Elisabeth   +3 more
openaire   +3 more sources