Results 21 to 30 of about 534,042 (160)

A Limited Course of Soluble CD83 Delays Acute Cellular Rejection of MHC-Mismatched Mouse Skin Allografts. [PDF]

Transplant International, 2007
CD83 is a surface marker expressed on matured dendritic cells (DCs). It plays a pivotal role in the mediation of DC/T cell interaction and induction of T-cell activation. Previous studies have suggested that a soluble form of CD83 could suppress DC maturation and inhibit T-cell activation and, as a result, it can prevent paralysis associated with ...
Min Fang, Cong-Yi Wang, Hui Yin
exaly   +3 more sources

Ferritin nanoparticles displaying rift valley fever virus glycoprotein elicit potent dendritic cell activation in vitro. [PDF]

Virol J
Rift Valley fever (RVF) is a mosquito-borne zoonosis of major concern for human and animal health, yet no licensed human vaccine exists. Here, we engineered a self-assembling nanoparticle vaccine candidate by genetically fusing the RVF virus glycoprotein
Rodrigues MQ, Cardoso I, Duarte N, Alves PM, Roldão A.   +4 more
europepmc   +2 more sources

Soluble CD83 Inhibits Acute Rejection by Up Regulating TGF-β and IDO Secretion in Rat Liver Transplantation

Transplant Immunology, 2021
Allogeneic transplantation immune tolerance is currently a hot research issue and soluble CD83(sCD83) is a novel immunomodulator with great potential in inducing transplantation tolerance.To investigate the mechanism of the immune tolerance effect of sCD83 on rat liver transplantation.A rat liver transplantation model was established to study the ...
Danxin Wang
exaly   +3 more sources

Eukaryotic Expression of Functionally Active Recombinant Soluble CD83 From HEK 293T Cells

Immunobiology, 2010
The cell surface protein CD83 belongs to the immunoglobulin super family and is highly expressed on mature dendritic cells (DCs). A membrane bound and a soluble form of CD83 (sCD83) have been described. Previously, the isolation of a purified recombinant sCD83 molecule from bacterial cultures using high pressure liquid chromatography was reported. This
Alexander Steinkasserer, Mirko Kummer, Petra Mühl-Zürbes   +2 more
exaly   +3 more sources

Alpha-toxin-elicited CX₃CL1 release in <i>Staphylococcus aureus</i> pneumonia impairs bactericidal function of human monocytes. [PDF]

mBio
Staphylococcus aureus is an important human pathogen causing severe invasive infections. Pathogenesis is attributed to a wide array of virulence factors, including several potent exotoxins such as the pore-forming α-toxin.
Mairpady Shambat S, Chen P, Barilla RM, Huemer M, Snäll J, Welin A, Cohen TS, Takahashi V, Berry SB, Gómez-Mejia A, Schweizer TA, Cunoosamy DM, Cajander S, Lourda M, Özenci V, Maggio EM, Schüpbach RA, Strålin K, Zinkernagel AS, Norrby-Teglund A, Svensson M.   +20 more
europepmc   +2 more sources

Determination of the Inhibitory Activity and Biological Half-Live of Soluble CD83: Comparison of Wild Type and Mutant Isoforms

Immunobiology, 2006
A soluble form of CD83 ("sCD83") has been shown to block DC-mediated T cell stimulation in vitro and an immunosuppressive role has also been shown in vivo using an experimental-autoimmune-encephalomyelits (EAE) model. Using recombinant mutational analyses, recently, we could show that sCD83 forms a homo-dimer, whereby four cysteines are involved in the
Alexander Steinkasserer, Matthias Lechmann   +1 more
exaly   +3 more sources

Integrative Network Analysis and Machine Learning Identify Cell Adhesion-Related Biomarkers and Immune Heterogeneity in Allergic Rhinitis. [PDF]

Immun Inflamm Dis
ABSTRACT Background Allergic rhinitis (AR) represents a highly prevalent inflammatory disorder of the nasal mucosa, but molecular indicators capable of capturing its disease‐specific transcriptional features remain insufficiently defined. This study aimed to identify cell adhesion‐related diagnostic biomarkers for AR and to investigate their immune ...
He G, Zhang L.
europepmc   +2 more sources

Tolerogenic Programming Promotes Human Cytomegalovirus Permissiveness in Dendritic Cells. [PDF]

Eur J Immunol
Tolerogenic programming renders dendritic cells more permissive to HCMV infection and limits their capacity to stimulate T cells. These findings suggest that tolerogenic DCs serve as a permissive cellular niche that may facilitate HCMV immune evasion. ABSTRACT Dendritic cells (DCs) are important targets of human cytomegalovirus (HCMV), yet the factors ...
Rahmel-Stein K, Becker J, Lange B, Krajewski L, Eiz-Vesper B, Kalinke U.   +5 more
europepmc   +2 more sources

Nsp1α of Porcine Reproductive and Respiratory Syndrome Virus Strain BB0907 Impairs the Function of Monocyte-Derived Dendritic Cells via the Release of Soluble CD83. [PDF]

J Virol, 2018
Porcine reproductive and respiratory syndrome virus (PRRSV), a virulent pathogen of swine, suppresses the innate immune response and induces persistent infection.
Chen X, Bai J, Liu X, Song Z, Zhang Q, Wang X, Jiang P.   +6 more
europepmc   +2 more sources

Porcine Reproductive and Respiratory Syndrome Virus Modulates the Switch of Macrophage Polarization from M1 to M2 by Upregulating MoDC-Released sCD83

Viruses, 2023
Porcine reproductive and respiratory syndrome virus (PRRSV), the most economically important infectious disease of pigs, elicits poor innate and adaptive immune responses. Soluble CD83 (sCD83), a secretion from various immune cell populations, especially
Xingyu Gong, Tianyi Ma, Qiaoya Zhang, Yanhong Wang, Chengchuang Song, Min Lai, Chunlei Zhang, Xingtang Fang, Xi Chen   +8 more
doaj   +1 more source