Results 91 to 100 of about 15,414 (258)

Insights into the potential role of sEH inhibition in the prevention and progression of neurological disorders

Endocrine and Metabolic Science
Neurological disorders are associated with decreased blood supply to the brain, neuronal damage, oxidative stress, and inflammation. While treatments are limited, soluble epoxide hydrolase inhibitors can be useful in alleviating neurological disorders ...
Mamatha Gavisiddaiah, Sumanta Kumar Goswami, Manali Somanna, Bruce D. Hammock, Kenganora Mruthunjaya, Abigail Fielding, Dithu Thekkekkara, Santhepete Nanjundaiah Manjula   +7 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibitor: A Novel Potential Therapeutic or Prophylactic Drug for Psychiatric Disorders

Frontiers in Pharmacology, 2019
Psychiatric disorders, including depression and schizophrenia, affect millions of individuals worldwide. However, the precise neurobiology of psychiatric disorders remains unclear. Accumulating evidence suggests that various inflammatory processes play a
Qian Ren, Qian Ren
doaj   +1 more source

The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension [PDF]

, 2016
Metabolic pathways enriched with genes differentially expressed in ISIAH and WAG renal medulla.
Arcady L. Markel, Larisa A. Fedoseeva, Marina A. Ryazanova, Nikita I. Ershov, Olga E. Redina, Vadim M. Efimov   +5 more
core   +6 more sources

Technological Advancements in Carotenoid‐Based Encapsulated Systems: Emerging Trends in Health‐Promoting Benefits and Their Role in Nutrient Delivery

eFood, Volume 6, Issue 6, December 2025.
Encapsulation has emerged as a promising strategy to enhance carotenoid stability, bioavailability, and antioxidant capacity. This technique involves enclosing carotenoids within protective materials at the micro or nanoscale, protecting against environmental, processing, and gastrointestinal stresses.
Mian Shamas Murtaza, Bismillah Mubeen, Sanabil Yaqoob, Tabussam Tufail, Mian Anjum Murtaza, Umar Farooq, Ali Ikram, Muhammad Tayyab Arshad, Yongkun Ma, Muhammed Adem Abdullahi   +9 more
wiley   +1 more source

Soluble Epoxide Hydrolase Inhibition Protected against Angiotensin II-induced Adventitial Remodeling

Scientific Reports, 2017
Epoxyeicosatrienoic acids (EETs), the metabolites of cytochrome P450 epoxygenases derived from arachidonic acid, exert important biological activities in maintaining cardiovascular homeostasis.
Chi Zhou, Jin Huang, Qing Li, Jiali Nie, Xizhen Xu, Dao Wen Wang   +5 more
doaj   +1 more source

Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low‐density lipoproteins in isolated perfused rat livers

Physiological Reports, 2021
Oxylipins are metabolites of polyunsaturated fatty acids that mediate cardiovascular health by attenuation of inflammation, vascular tone, hemostasis, and thrombosis.
Rachel E. Walker, Olga V. Savinova, Theresa L. Pedersen, John W. Newman, Gregory C. Shearer   +4 more
doaj   +1 more source

Immobilization of α-amylase from anoxybacillus sp. SK3-4 on relizyme and immobead supports [PDF]

, 2016
α-Amylase from Anoxybacillus sp. SK3-4 (ASKA) is a thermostable enzyme that produces a high level of maltose from starches. A truncated ASKA (TASKA) variant with improved expression and purification efficiency was characterized in an earlier study.
Chan, K. G., Goh, K. M., Kahar, U. M., Sani, M. H.   +3 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver. Role for omega-3 epoxides [PDF]

, 2018
Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases that have inflammation as a common underlying cause. sEH limits tissue levels of cytochrome P450 (CYP) epoxides derived from omega-6 and omega-3 polyunsaturated ...
Alcaraz-Quiles, José, Arroyo, Vicente, Clària i Enrich, Joan, García-Alonso, Verónica, Hammock, Bruce D., Hwang, Sung H., Lopategi, Aritz, López Vicario, Cristina, Rius, Bibiana, Titos Rodríguez, Esther   +9 more
core   +1 more source

EETs Reduction Contributes to Granulosa Cell Senescence and Endometriosis‐Associated Infertility via the PI3K/AKT/mTOR Signaling Pathway

Advanced Science, Volume 12, Issue 42, November 13, 2025.
1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin, Weijia Gu, Xiaomei Tong, Mengru Lai, Yi Zhang, Na Liu, Xiaoying Jin, Chao Li, Dong Huang, Feng Zhou, Yongdong Dai, Songying Zhang   +11 more
wiley   +1 more source