Results 101 to 110 of about 15,414 (258)

Improving the 'tool box' for robust industrial enzymes. [PDF]

, 2017
This is the final version of the article. Available from Springer Verlag via the DOI in this record.The speed of sequencing of microbial genomes and metagenomes is providing an ever increasing resource for the identification of new robust biocatalysts ...
Littlechild, JA
core   +1 more source

Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids[S]

Journal of Lipid Research, 2010
Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely accepted but the mechanism(s) by which these fatty acids act remains unclear.
Christophe Morisseau, Bora Inceoglu, Kara Schmelzer, Hsing-Ju Tsai, Steven L. Jinks, Christine M. Hegedus, Bruce D. Hammock   +6 more
doaj   +1 more source

Regulation of KCa2.3 andendothelium-dependent hyperpolarization (EDH) in the rat middle cerebral artery: the role of lipoxygenase metabolites and isoprostanes [PDF]

, 2014
Background and Purpose. In rat middle cerebral arteries, endothelium-dependent hyperpolarization (EDH) is mediated by activation of calcium-activated potassium(KCa) channels specifically KCa2.3 and KCa3.1.
Campbell, William B, Gauthier, Kathryn M, McNeish, Alister J   +2 more
core   +1 more source

Enriching stabilizing mutations through automated analysis of molecular dynamics simulations using BoostMut

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Thermostability is a critical goal in protein engineering for applications of biocatalysts and biomedicines. Despite striking advances in biomolecular predictive modeling, reliably identifying stabilizing mutations remains challenging. Previously, molecular dynamics (MD) simulations and visual inspection have been used as a secondary filter to
Kerlen T. Korbeld, Maximilian J. L. J. Fürst   +1 more
wiley   +1 more source

Phosphatase activity of soluble Epoxide Hydrolase (sEH) [PDF]

, 2016
関西学院大
Endang Rinawati Purba, Rinawati Purba Endang   +1 more
core   +3 more sources

Comparative Structural Analysis of Escherichia Coli Cyay at Room and Cryogenic Temperatures Using Macromolecular and Serial Crystallography

ChemBioChem, Volume 26, Issue 20, October 31, 2025.
Room‐temperature (RT) crystallography of E. coli CyaY, the bacterial frataxin homolog, reveals subtle but functionally relevant differences from cryogenic structures. The conserved fold shows distinct side‐chain conformations and water networks, highlighting dynamics often hidden at low temperatures.
Alaleh Shafiei, Nilufer Baldir, Jongbum Na, Jin Hae Kim, Hasan DeMirci   +4 more
wiley   +1 more source

Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer’s disease

Journal of Neuroinflammation, 2019
Background Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with COOH-terminal hydrolase and NH2-terminal lipid phosphatase activities. It is expressed in various cell types in the brain and is involved in the pathogenesis of inflammatory and ...
Hsueh-Te Lee, Kuan-I Lee, Chia-Hui Chen, Tzong-Shyuan Lee   +3 more
doaj   +1 more source

Gene evolution of epoxide hydrolases and recommended nomenclature [PDF]

, 1995
We have analyzed amino acid sequence relationships among soluble and microsomal epoxide hydrolases, haloacid dehalogenases, and a haloalkane dehalogenase.
Arand, Michael, Beetham, J K, Belknap, W R, Garbarino, J, Grant, D, Hammock, B D, Kiyosue, T, Oesch, F, Pinot, F, Shinozaki, K   +9 more
core   +1 more source

Tailoring Regioselectivity‐Controlled UDP‐Glycosyltransferase for Bidirectional Glycosylation of Tyrosol via Free Energy‐Driven Pocket Reshaping and Tunnel Engineering

Advanced Science, Volume 12, Issue 40, October 27, 2025.
To address inherent limitations in regioselectivity and catalytic efficiency of UDP‐glycosyltransferases, an integrated strategy combining free‐energy driven pocket reshaping and tunnel engineering is developed. This strategy enables UGTBL1 to bidirectional glycosylation of tyrosol, synthesizing salidroside or icariside D2 without extensive screening ...
Ziyu Zhang, Jingyi Chen, Zuozhi Liang, Wenming Shao, Zhen Gao, Bin Wu, Bingfang He, Gerhard Schenk   +7 more
wiley   +1 more source

Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis

Frontiers in Pharmacology, 2019
Osteoarthritis (OA) is a degenerative joint disease that causes pain and bone deterioration driven by an increase in prostaglandins (PGs) and inflammatory cytokines.
Cindy B. McReynolds, Cindy B. McReynolds, Sung Hee Hwang, Sung Hee Hwang, Jun Yang, Jun Yang, Debin Wan, Karen Wagner, Karen Wagner, Christophe Morisseau, Dongyang Li, William K. Schmidt, Bruce D. Hammock, Bruce D. Hammock   +13 more
doaj   +1 more source