Results 11 to 20 of about 15,414 (258)

Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism

Frontiers in Molecular Neuroscience, 2020
The bifunctional enzyme soluble epoxide hydrolase (sEH) is found in all regions of the brain. It has two different catalytic activities, each assigned to one of its terminal domains: the C-terminal domain presents hydrolase activity, whereas the N ...
Michelle Flores Domingues, Michelle Flores Domingues, Natalia Callai-Silva, Natalia Callai-Silva, Angela Regina Piovesan, Celia Regina Carlini, Celia Regina Carlini, Celia Regina Carlini   +7 more
doaj   +3 more sources

Inhibition of Soluble Epoxide Hydrolase for Renal Health [PDF]

Frontiers in Pharmacology, 2019
A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the corresponding vicinal diols, which are usually inactive or less active than the epoxide substrates.
Jun-Yan Liu, Jun-Yan Liu
doaj   +3 more sources

Disrupting Dimerization Translocates Soluble Epoxide Hydrolase to Peroxisomes.

PLoS ONE, 2016
The epoxyeicosatrienoic acid (EET) neutralizing enzyme soluble epoxide hydrolase (sEH) is a neuronal enzyme, which has been localized in both the cytosol and peroxisomes.
Jonathan W Nelson, Anjali J Das, Anthony P Barnes, Nabil J Alkayed   +3 more
doaj   +3 more sources

Polycyclic compounds as soluble epoxide hydrolase inhibitors

Invention Disclosure
In this invention, a novel family of benzohomoadamantane-based soluble epoxide hydrolase inhibitors is disclosed. The benzohomoadamantane scaffold is a polycyclic, readily accessible, system that features a homoadamantane unit fused with an aromatic ring.
S. Codony, E. Valverde, C. Galdeano, A.L. Turcu, R. Leiva, S. Vázquez   +5 more
doaj   +2 more sources

Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology [PDF]

Physiological Reviews, 2012
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis.
John D. Imig
openalex   +4 more sources

Soluble Epoxide Hydrolase Inhibition Confers Neuroprotection via PPAR-α Activation During Intracerebral Hemorrhage. [PDF]

J Neurosci Res
Inhibition of soluble epoxide hydrolase (sEH) exerts a neuroprotective effect in a collagenase‐induced hemorrhagic stroke model, likely by increasing EETs. This neuroprotection appears to be mediated, at least in part, by the regulation of antioxidant balance.
Martínez-Torres AM, Navarro-Mabarak C, Morán J.   +2 more
europepmc   +2 more sources

Mechanism of Soluble Epoxide Hydrolase [PDF]

Journal of Biological Chemistry, 1995
Two rapid assays for the soluble epoxide hydrolase (sEH) are described. First, a sensitive radiometric assay based on thin-layer chromatography of [(14)C]-cis-9,10-epoxystearic acid and its corresponding diol ((14)C]-9,10-dihydroxystearic acid) is described.
Babak Borhan, A. Daniel Jones, Franck Pinot, David F. Grant, Mark J. Kurth, Bruce D. Hammock   +5 more
  +7 more sources

Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors [PDF]

Frontiers in Pharmacology, 2020
John D. Imig, Christophe Morisseau
doaj   +3 more sources

Soluble Epoxide Hydrolase and Diabetes Complications

International Journal of Molecular Sciences, 2022
Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to macrovascular complications, such as heart failure, peripheral arterial disease, and large vessel stroke.
Natasha Z. Anita, Walter Swardfager
openaire   +2 more sources

Soluble Epoxide Hydrolase in Atherosclerosis [PDF]

Current Atherosclerosis Reports, 2010
Like many eicosanoids, epoxyeicosatrienoic acids (EETs) have multiple biological functions, including reduction of blood pressure, inflammation, and atherosclerosis in multiple species. Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols.
Wang, Yi-Xin Jim, Ulu, Arzu, Zhang, Le-Ning, Hammock, Bruce   +3 more
openaire   +4 more sources