Results 21 to 30 of about 15,414 (258)

Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease

Cells, 2022
Cell responses to changes in their redox state are significantly mediated by reversible oxido-reductive post-translational modifications of proteins, potentially altering their activities or interactions.
Rebecca Charles, Philip Eaton
doaj   +1 more source

Identifying simultaneous matrix metalloproteinases/soluble epoxide hydrolase inhibitors [PDF]

Molecular and Cellular Biochemistry, 2021
Abstract Matrix metalloproteinase (MMP) and soluble epoxide hydrolase (sEH) have completely unrelated biological functions, however, their dysregulation produce similar effects on biological systems. Based on the similarity in the reported structural requirements for their inhibition, the current study aimed to identify a simultaneous inhibitor
Ahmed A. El-Sherbeni, Rabia Bhatti, Fadumo A. Isse, Ayman O.S. El-Kadi   +3 more
openaire   +2 more sources

Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation

Frontiers in Pharmacology, 2021
The soluble epoxide hydrolase (sEH) enzyme is a major regulator of bioactive lipids. The enzyme is highly expressed in liver and kidney and modulates levels of endogenous epoxy-fatty acids, which have pleiotropic biological effects including limiting ...
Karen M. Wagner, Jun Yang, Christophe Morisseau, Bruce D. Hammock   +3 more
doaj   +1 more source

11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction [PDF]

, 2012
In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca2+-activated potassium (BK) channels. However, in
Daiber, Andreas, Fleming, Ingrid, Keserü, Benjamin, Loot, Annemarieke E., Moneke, Isabelle, Oelze, Matthias, Syzonenko, Tetyana   +6 more
core   +12 more sources

Synthesis and evaluation of isoquinolinyl and pyridinyl-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase to alleviate orofacial hyperalgesia in the rat. [PDF]

Biochem Biophys Rep
Carr D, Gunari S, Gorostiza G, Mercado M, Pavana L, Duong L, Gomez K, Salinas S, Garcia C, Tsang A, Morisseau C, Hammock BD, Pecic S, Kandasamy R.   +13 more
europepmc   +2 more sources

Inhibition of soluble epoxide hydrolase by natural isothiocyanates. [PDF]

Biochem Biophys Res Commun
The long-term goal of our research is to develop safe and effective soluble epoxide hydrolase (sEH) inhibitors. The objective of this study is to evaluate the potency and selectivity of six natural isothiocyanates (ITCs) as sEH inhibitors.Molecular docking was used to model likely interactions between the ligands and receptors.
Elbarbry F, Espiritu MJ, Soo K, Yee B, Taylor J.   +4 more
europepmc   +3 more sources

Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese

International Journal of Hypertension, 2020
Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives.
Liang Ma, Hailing Zhao, Meijie Yu, Yumin Wen, Tingting Zhao, Meihua Yan, Qian Liu, Yongwei Jiang, Yongtong Cao, Ping Li, Wenquan Niu   +10 more
doaj   +1 more source

Total plasma cytochrome P450‐soluble epoxide hydrolase oxylipins, apolipoprotein E ε4 carrier status, and white matter hyperintensities in cerebrovascular disease [PDF]

Alzheimers Dement
Abstract Background The cytochrome P450‐soluble epoxide hydrolase (CYP450‐sEH) pathway has been implicated in cerebral small vessel disease (cSVD) due to the anti‐inflammatory and vasoactive effects of epoxide species produced by CYP450, which are converted into diols by sEH.
Lin W, Ryoo S, Magliocco A, Anita N, Ruthirakuhan M, Huang C, Perfetto S, Munoz D, Roberts A, Binns M, Lang A, Symons S, Taha A, Swardfager W.   +13 more
europepmc   +2 more sources

Soluble epoxide hydrolase‐derived linoleic acid diols, cerebral small vessel disease markers and white matter microstructural integrity in type 2 diabetes mellitus [PDF]

Alzheimers Dement
Abstract Background While polyunsaturated fatty acids can be metabolized into beneficial, anti‐inflammatory epoxides, they are subsequently converted to inactive, cytotoxic diols by soluble epoxide hydrolase (sEH). Increased linoleic acid (LA)‐derived diols have been associated with poorer cognitive performance in type 2 diabetes mellitus (T2DM ...
Ryoo S, Lin W, Ruthirakuhan M, Wong Y, Anita N, Binns M, Montero‐Odasso M, Arnott S, Tartaglia C, Lang A, Symons S, Hegele R, MacIntosh B, Lanctôt K, Taha A, Black S, Swardfager W.   +16 more
europepmc   +2 more sources

Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice [PDF]

, 2019
Epoxy-fatty-acids (EpFAs), cytochrome P450 dependent arachidonic acid derivatives, have been suggested to have anti-inflammatory properties, though their effects on autoimmune diseases like systemic lupus erythematosus (SLE) have yet to be investigated ...
Dragun, Duska, Enghard, Philipp, Gollasch, Maik, Hammock, Bruce D., Klocke, Jan, Riemekasten, Gabriela, Rudolph, Birgit, Schunck, Wolf-Hagen, Ulu, Arzu, Wu, Kaiyin   +9 more
core   +2 more sources