Results 31 to 40 of about 15,414 (258)

Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

Alzheimer’s Research & Therapy, 2021
Background Alzheimer’s disease, cardiovascular disease, and other cardiometabolic disorders may share inflammatory origins. Lipid mediators, including oxylipins, endocannabinoids, bile acids, and steroids, regulate inflammation, energy metabolism, and ...
Kamil Borkowski, Theresa L. Pedersen, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, Chadwick M. Hales, Eric B. Dammer, Colette Blach, Gregory Louie, Rima Kaddurah-Daouk, John W. Newman, Alzheimer’s Disease Metabolomics Consortium   +11 more
doaj   +1 more source

Soluble epoxide hydrolase inhibition alleviates chemotherapy induced neuropathic pain

Frontiers in Pain Research, 2023
Chemotherapy induced peripheral neuropathy (CIPN) is a particularly pernicious form of neuropathy and the associated pain is the primary dose-limiting factor of life-prolonging chemotherapy treatment.
Ashley A. Takeshita, Bruce D. Hammock, Bruce D. Hammock, Karen M. Wagner, Karen M. Wagner   +4 more
doaj   +1 more source

Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies.
Aline Mello, Ming-Fo Hsu, Shinichiro Koike, Bryan Chu, Jeff Cheng, Jun Yang, Christophe Morisseau, Natalie J. Torok, Bruce D. Hammock, Fawaz G. Haj   +9 more
doaj   +1 more source

Soluble Epoxide Hydrolase [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Objective— Sex differences in cerebral ischemic injury are, in part, arrtibutable to the differences in cerebrovascular perfusion. We determined whether the brain microvascular endothelial cells (ECs) isolated from the female brain are more resistant to ischemic injury compared with male ECs, and whether the difference is ...
Nandita C, Gupta, Catherine M, Davis, Jonathan W, Nelson, Jennifer M, Young, Nabil J, Alkayed   +4 more
openaire   +2 more sources

Evidence for the role of EPHX2 gene variants in anorexia nervosa. [PDF]

, 2013
Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants.
Bansal, V, Berenson, G, Bergen, AW, Berrettini, W, Bloss, CS, Brandt, H, Bulik, CM, Carson, A, Chen, W, Crawford, S, Crow, S, Darst, BF, Duvvuri, V, Fichter, MM, Galvez, L, Halmi, KA, Johnson, C, Kaplan, AS, Kaye, W, Keel, P, Klump, KL, La Via, M, Levy, S, Libiger, O, Lilenfeld, L, Magistretti, P, Mitchell, JE, Murray, S, Pham, P, Phillips, T, Plotnicov, K, Rotondo, A, Schork, NJ, Scott-Van Zeeland, AA, Shih, PB, Smith, EN, Srinivasan, S, Strober, M, Tewhey, R, Tisch, R, Topol, EJ, Torkamani, A, Treasure, J, Villarasa, N, Wineinger, N, Woodside, DB, Zhang, G   +46 more
core   +1 more source

Orally Bioavailable Potent Soluble Epoxide Hydrolase Inhibitors [PDF]

Journal of Medicinal Chemistry, 2007
A series of N,N'-disubstituted ureas having a conformationally restricted cis- or trans-1,4-cyclohexane alpha to the urea were prepared and tested as soluble epoxide hydrolase (sEH) inhibitors. This series of compounds showed low nanomolar to picomolar activities against recombinant human sEH.
Sung Hee, Hwang, Hsing-Ju, Tsai, Jun-Yan, Liu, Christophe, Morisseau, Bruce D, Hammock   +4 more
openaire   +2 more sources

Primary Structure and Catalytic Mechanism of the Epoxide Hydrolase from Agrobacterium radiobacter AD1 [PDF]

, 1997
The epoxide hydrolase gene from Agrobacterium radiobacter AD1, a bacterium that is able to grow on epichlorohydrin as the sole carbon source, was cloned by means of the polymerase chain reaction with two degenerate primers based on the N-terminal and C ...
Altschul, Andrade, Arand, Arand, Armstrong, Ausubel, Beetham, Beetham, Bell, Burley, Dick B. Janssen, Dı́az, Falany, Fujio, Geourjon, Grant, Hassett, Hecht, Heidelbach, Innis, Itzhaki, Jacobs, Janssen, Janssen, Johnson, Kawasaki, Kiyosue, Knehr, Kunkel, Lacourciere, Loewenthal, Marko Fennema, Mehta, Miller, Minke Smids, Noble, Ollis, Pries, Provencher, Rick Rink, Rost, Sambrook, Sanger, Schanstra, Skoda, Solovyev, Sreerama, Stapleton, Studier, Thomas, Thompson, Uwe Dehmel, Van den Wijngaard, Verschueren, Verschueren, Wang, Wilson, Winkler, Wojtasek, Yanisch-Perron   +59 more
core   +3 more sources

Soluble Epoxide Hydrolase Inhibitors Regulate Ischemic Arrhythmia by Targeting MicroRNA-1

Frontiers in Physiology, 2021
Background: Soluble epoxide hydrolase inhibitors (sEHis) inhibit the degradation of epoxyeicosatrienoic acids (EETs) in cells, and EETs have antiarrhythmic effects.
Yanying Chen, Qiong Liu, Tian Yang, Li Shen, Danyan Xu   +4 more
doaj   +1 more source

Soluble Epoxide Hydrolase Dimerization Is Required for Hydrolase Activity [PDF]

Journal of Biological Chemistry, 2013
Soluble epoxide hydrolase (sEH) plays a key role in the metabolic conversion of the protective eicosanoid 14,15-epoxyeicosatrienoic acid to 14,15-dihydroxyeicosatrienoic acid. Accordingly, inhibition of sEH hydrolase activity has been shown to be beneficial in multiple models of cardiovascular diseases, thus identifying sEH as a valuable therapeutic ...
Jonathan W, Nelson, Rishi M, Subrahmanyan, Sol A, Summers, Xiangshu, Xiao, Nabil J, Alkayed   +4 more
openaire   +2 more sources

Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase

Current Issues in Molecular Biology, 2022
The quaternary isoquinoline alkaloids of palmatine (1), berberine (2), and jatrorrhizine (3) were evaluated in terms of their ability to inhibit soluble epoxide hydrolase (sEH). They had similar inhibitory activities, with IC50 values of 29.6 ± 0.5, 33.4
Jang Hoon Kim, Chong Woon Cho, Mok Hur, Woo Tae Park, Youn-Ho Moon, Sung-Cheol Koo, Yun-Chan Hur, Jong Seong Kang, Ik Soo Lee   +8 more
doaj   +1 more source