Results 61 to 70 of about 15,414 (258)

Soluble epoxide hydrolase in the human placenta throughout gestation

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: To investigate the spatial and temporal changes of soluble epoxide hydrolase (sEH) in the human placenta throughout gestation and to study the effects of hypoxia-reoxygenation (HR) on the expression of sEH in villous explants in vitro ...
Tai-Ho Hung, Szu-Fu Chen, T'sang-T'ang Hsieh   +2 more
doaj   +1 more source

TPPU inhibits inflammation-induced excessive autophagy to restore the osteogenic differentiation potential of stem cells and improves alveolar ridge preservation

Scientific Reports, 2023
Inflammation-induced autophagy is a double-edged sword. Dysfunction of autophagy impairs the differentiation capacity of mesenchymal stem cells and enhances inflammation-induced bone loss.
Haixia Dang, Weixian Chen, Lan Chen, Xinru Huo, Fu Wang   +4 more
doaj   +1 more source

Soluble Epoxide Hydrolase

Asian Journal of Pharmaceutical Research and Development
Epoxyeicosatrienoic acids (EETs) have numerous cardiovascular benefits, including vasodilation, anti-inflammatory actions, and anti-migratory effects on vascular smooth muscle cells. However, sEH, an enzyme that breaks down EETs into diols, limits these benefits.
Pooja M. Sontakke, Suraj G. Malpani, Pooja R. Tange, MD Rayees Ahmad, Vishweshwar M. Dharashive   +4 more
openaire   +1 more source

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins

Advanced Science, EarlyView.
Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang, Yihang Xiao, Yingxiao Gao, Mingxuan Wu   +3 more
wiley   +1 more source

Role of soluble epoxide hydrolase in pain and depression comorbidity

Neurobiology of Disease
The coexistence of chronic pain and depression in clinical practice places a substantial social burden and profoundly impacts in patients. Although a clear correlation exists, the underlying mechanism of comorbidity between chronic pain and depression ...
Yuchen Bu, Siqi Yang, Di Wang, Suwan Hu, Qi Zhang, Zifeng Wu, Chun Yang   +6 more
doaj   +1 more source

Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. [PDF]

PLoS ONE, 2014
Acute pancreatitis (AP) is a frequent gastrointestinal disorder that causes significant morbidity, and its incidence has been progressively increasing. AP starts as a local inflammation in the pancreas that often leads to systemic inflammatory response ...
Ahmed Bettaieb, Samah Chahed, George Tabet, Jun Yang, Christophe Morisseau, Stephen Griffey, Bruce D Hammock, Fawaz G Haj   +7 more
doaj   +1 more source

Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors [PDF]

Bioorganic & Medicinal Chemistry Letters, 2014
A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM. 1,6-(Hexamethylene)bis[(adamant-1-yl)urea] (3b) was found to be a potent slow tight binding inhibitor (IC50=0.5 nM) with a strong binding to sEH (Ki=3.1 nM) and a ...
Vladimir Burmistrov, Christophe Morisseau, Kin Sing Stephen Lee, Diyala S. Shihadih, Todd R. Harris, Gennady M. Butov, Bruce D. Hammock   +6 more
openaire   +4 more sources

Molecular changes in agroinfiltrated leaves of Nicotiana benthamiana expressing suppressor of silencing P19 and coronavirus‐like particles

Plant Biotechnology Journal, EarlyView.
Summary The production of coronavirus disease 2019 vaccines can be achieved by transient expression of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 in agroinfiltrated leaves of Nicotiana benthamiana. Relying on bacterial vector Agrobacterium tumefaciens, this process is favoured by co‐expression of viral silencing suppressor
Louis‐Philippe Hamel, Francis Poirier‐Gravel, Marie‐Ève Paré, Rachel Tardif, Marc‐André Comeau, Pierre‐Olivier Lavoie, Andréane Langlois, Marie‐Claire Goulet, Dominique Michaud, Marc‐André D'Aoust   +9 more
wiley   +1 more source

Association between the soluble epoxide hydrolase gene and preeclampsia

Hypertension in Pregnancy, 2017
Objective: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women.
Ismail Sari, Hatice Pinarbasi, Ergun Pinarbasi, Caglar Yildiz   +3 more
doaj   +1 more source