Results 81 to 90 of about 15,414 (258)

Chemical Proteomics Reveals Soluble Epoxide Hydrolase as a Therapeutic Target for Ocular Neovascularization [PDF]

, 2018
The standard-of-care therapeutics for the treatment of ocular neovascular diseases like wet age-related macular degeneration (AMD) are biologics targeting vascular endothelial growth factor signaling.
Boulton, Michael E., Corson, Timothy W., Fei, Xiang, Kharwadkar, Rakshin, Lee, Bit, Meroueh, Samy, Mitter, Sayak K., Park, Bomina, Qi, Xiaoping, Sardar Pasha, Sheik Pran Babu, Seo, Seung-Yong, Si, Yubing, Sulaiman, Rania S., Sun, Wei   +13 more
core   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Abstract Aging is a complex, multifaceted process affecting all organ systems, with vascular aging playing a central role in organismal health decline. Beyond its role in circulation, the vascular system acts as a dynamic interface between tissues, influencing countless physiological functions such as tissue regeneration and repair, immune responses ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Effects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patients [PDF]

, 2014
BACKGROUND: The aim of this study was to investigate the effect of two genetic polymorphisms in the coding regions (exon 3 and exon 4) of the EPHX1 gene, ie, 337T>C and 416A>G, respectively, on the metabolism of carbamazepine (CBZ) 10,11-epoxide (the ...
AGNELLO, Luisa, BAZZA, Federica, BELLIA, Chiara, BIVONA, Giulia, CARUSO, Antonietta, CIACCIO, Marcello, LO SASSO, Bruna, Pivetti, A, SCAZZONE, Concetta   +8 more
core   +2 more sources

Lipoprotein‐Mediated Esterified Oxylipins Changed in Alzheimer's Disease

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Inflammation is crucial in Alzheimer's Disease (AD) pathology, with oxylipins – oxidized lipid derivatives of polyunsaturated fatty acids – serving as potent modulators. Particularly, dysregulation of soluble epoxide hydrolase (sEH), which converts pro‐resolving epoxides to pro‐inflammatory diols, has been observed in blood and ...
Sitong Zhou, Kamil Borkowski, Angela M. Zivkovic, Izumi Maezawa, John W. Newman, Lee‐Way Jin   +5 more
wiley   +1 more source

Detoxification Strategy of Epoxide Hydrolase [PDF]

, 2003
The human microsomal epoxide hydrolase, a single enzyme, has to detoxify a broad range of structurally diverse, potentially genotoxic epoxides that are formed in the course of xenobiotic metabolism. The enzyme has developed a unique strategy to combine a
Arand, Michael, Cronin, Annette, Hengstler, Jan G., Herrero Plana, Maria Elena, Lohmann, Matthias, Oesch, Franz   +5 more
core  

The role of epoxyeicosatrienoic acids in the cardiovascular system. [PDF]

, 2015
There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ...
Cheriyan, J, McEniery, C, Mäki-Petäjä, K, Wilkinson, IB, Yang, L   +4 more
core   +2 more sources

Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis [PDF]

, 2018
• Cyp2j4 deletion in rats offers a simplified genetic landscape as opposed to the mice locus, which is under significant allelic expansion. • Under different metabolic stresses (aging, cafeteria diet), Cyp2j4−/− rats show an accelerated adipogenesis ...
Abraham, Abreu-Vieira, Behmoaras, Behmoaras, Brons, Crewe, Cristancho, Darlington, Dennis, du Plessis, Farmer, Fleming, Fleming, Forman, Fujiki, Fujimori, Giordano, Imig, Inceoglu, Khan, Kim, Kliewer, Kusminski, Lefterova, Li, Liu, Luo, Luria, Mariman, Martinez-Micaelo, Martinez-Micaelo, Medina-Gomez, Morisseau, Nadler, Ng, Odegaard, Oga, Otero, Palmer, Panigrahy, Panigrahy, Pellegrinelli, Rosen, Sampey, Schafer, Scherer, Semple, Serhan, Soccio, Sun, Sun, Sun, Tanaka, Tontonoz, Uccelli, Umek, van der Poorten, Voigt, Waldman, Wamberg, Wang, Wang, Wei, Wernstedt Asterholm, Wernstedt Asterholm, Wu, Yaghootkar, Zeldin, Zha, Zhang, Zhang, Zhou   +71 more
core   +4 more sources

Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress

Cell Reports, 2019
Summary: Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few have evaluated the role of peripheral organs in ...
Xi-He Qin, Zhou Wu, Jing-Hua Dong, Yuan-Ning Zeng, Wen-Chao Xiong, Ce Liu, Meng-Yao Wang, Min-Zhen Zhu, Wen-Jun Chen, Yuan Zhang, Qi-Yuan Huang, Xin-Hong Zhu   +11 more
doaj   +1 more source

Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation [PDF]

, 2017
Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus ...
Abete, Lorena, Barile, Fabio, Bozovic, Mijat, DI GIACOMO, Silvia, DI SOTTO, Antonella, Izzo, Angelo A, Mazzanti, Gabriela, Parisi, Olga A, Ragno, Rino, Vitalone, Annabella   +9 more
core   +1 more source

The Role and Therapeutic Potential of the cGAS‐STING Signaling Pathway in Alzheimer's Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
This work reveals the relationship between the cGAS‐STING signaling pathway and the pathological mechanisms of Alzheimer's disease.The role of the cGAS‐STING signaling pathway in AD pathology. AD leads to the production of neutrophil extracellular traps (NETs), endoplasmic reticulum (ER) stress, and the release of mitochondrial DNA (mtDNA) and nuclear ...
Xue Li, Wei Gao, Qiuyan Ye, Honglin Li
wiley   +1 more source