Results 211 to 220 of about 217,506 (260)

Soluble IL-6 Receptor Potentiates the Antagonistic Activity of Soluble gp130 on IL-6 Responses

The Journal of Immunology, 1998
Abstract Soluble receptors for several cytokines have been detected in body fluids and are believed to modulate the cytokine response by binding the ligand and thereby reducing its bioavailability. In the case of IL-6, the situation is more complex.
Müller-Newen, Gerhard, Küster, Andrea, Hemmann, Ulrike, Keul, Radovan, Horsten, Ursula, Martens, Astrid, Graeve, Lutz, Wijdenes, John N. N., Heinrich, Peter   +8 more
openaire   +2 more sources

Preparation of soluble murine IL-6 receptor and anti-murine IL-6 receptor antibodies

The Journal of Immunology, 1991
Abstract Starting with a previously isolated cDNA clone encoding murine IL-6R, a stable transformed Chinese hamster ovary cell line constitutively expressing soluble murine IL-6R (smIL-6R) has been established. The smIL-6R was purified to homogeneity by sequential filtration and chromatography of culture medium.
T, Saito, K, Yasukawa, H, Suzuki, K, Futatsugi, T, Fukunaga, C, Yokomizo, Y, Koishihara, H, Fukui, Y, Ohsugi, H, Yawata   +9 more
openaire   +2 more sources

Trans-signaling of interleukin-6 (IL-6) is mediated by the soluble IL-6 receptor, but not by soluble CD5

Biochemical and Biophysical Research Communications, 2017
IL-6 exerts its pleiotropic activities on its target cells via the IL-6 alpha-receptor (IL-6R), which is expressed on a limited number of cell types. IL-6 can further signal via soluble forms of its receptor (sIL-6R), a process that has been termed trans-signaling. Recently, CD5 was described as an alternative alpha-receptor for IL-6 on B cells leading
Samadhi Aparicio-Siegmund, Malte Deseke, Annett Lickert, Christoph Garbers   +3 more
openaire   +2 more sources

Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130

Immunology Letters, 1992
IL-6 mediates its pleiotropic functions through two membrane proteins, a ligand-binding molecule (IL-6 receptor, IL-6R) and a non-ligand-binding signal transducer (gp130). Starting with a previously isolated cDNA clone encoding human gp130, recombinant soluble gp130 (sgp130) lacking the transmembrane and cytoplasmic regions was expressed in COS7 cells ...
K, Yasukawa, K, Futatsugi, T, Saito, H, Yawata, M, Narazaki, H, Suzuki, T, Taga, T, Kishimoto   +7 more
openaire   +2 more sources

IL-6-soluble IL-6 receptor complex inhibits the proliferation of dermal fibroblasts

International Journal of Immunopharmacology, 1996
A number of investigators has reported that there is increased production of interleukin-6 (IL-6) by fibroblasts and monocytes from the patients with systemic sclerosis (SS). However, the precise role of IL-6 in the pathogenesis of SS remains unclear. On the basis of our previous study showing that the complex of IL-6 and soluble IL-6 receptor (sIL-6R)
M, Mihara, Y, Moriya, Y, Ohsugi
openaire   +2 more sources

Activation of gp 130 by IL‐6/soluble IL‐6 receptor induces neuronal differentiation

European Journal of Neuroscience, 1997
AbstractInterleukin‐6 (IL‐6) on target cells binds to the specific IL‐6 receptor (IL‐6R) and subsequently induces homodimerization of the signal‐transducing protein gpl30. Cells which express gpl30 but no IL‐6R and which therefore do not respond to IL‐6 can be stimulated by the complex of IL‐6 and soluble IL‐6R (slL‐6R).
P, März, T, Herget, E, Lang, U, Otten, S, Rose-John   +4 more
openaire   +2 more sources

Normal platelets possess the soluble form of IL-6 receptor

Cytokine, 2004
Interleukin 6 is a multifunctional cytokine that exerts its biological activity through binding to an 80 Kd specific receptor (IL-6Ralpha) and a 130 Kd signal-transducing unit (gp130). A 55 Kd soluble IL-6R (IL-6sR) has also been described which, after binding to IL-6 is also able to activate gp130.
Rosana F, Marta, Nora P, Goette, Paola R, Lev, Carlos D, Chazarreta, Carlos J, Pirola, Felisa C, Molinas   +5 more
openaire   +2 more sources

Soluble IL-6 receptor levels in patients on chronic hemodialysis

Clinical Nephrology, 2002
Osteitis fibrosa, a part of the spectrum of renal osteodystrophy, is characterized by high bone turnover as a result of high circulating levels of parathyroid hormone (PTH). It is well accepted that the bone resorptive effects of PTH occur, at least in part, by inducing osteoblasts to secrete cytokines that stimulate both differentiation and activation
S, Disthabanchong, E A, González, K J, Martin   +2 more
openaire   +2 more sources

Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients

Journal of Psychiatric Research, 2011
Recent studies indicate a role of excessive interleukin-6 (IL-6) signaling in the pathogenesis of schizophrenia. A previous study reported a significant association of schizophrenia with the IL-6 receptor (IL-6R) gene Asp358Ala polymorphism, which is known to regulate circulating IL-6 and soluble IL-6R (sIL-6R) levels in healthy subjects.
Daimei, Sasayama, Chisato, Wakabayashi, Hiroaki, Hori, Toshiya, Teraishi, Kotaro, Hattori, Miho, Ota, Masanori, Ishikawa, Kunimasa, Arima, Teruhiko, Higuchi, Naoji, Amano, Hiroshi, Kunugi   +10 more
openaire   +2 more sources

FACTORS INFLUENCING THE EFFECT OF THE SOLUBLE IL-6 RECEPTOR ON IL-6 RESPONSES IN HepG2 HEPATOCYTES

Cytokine, 2000
The soluble IL-6 receptor (sIL-6R) can increase IL-6-induced signalling by forming a complex with IL-6 and membrane-bound gp130 (the receptor beta chain which transduces signals). The conditions affecting this response to sIL-6R were studied using fibrinogen release from HepG2 hepatocytes.
J, Paysant, R, Blanqué, M, Vasse, C, Soria, J, Soria, C R, Gardner   +5 more
openaire   +2 more sources