Results 221 to 230 of about 217,506 (260)

Soluble interleukin‐6 (IL‐6) receptor augments central effects of IL‐6 in vivo

The FASEB Journal, 1995
The pleiotropic cytokine interleukin‐6 (IL‐6) controls both the peripheral and central components of the acute‐phase response. These activities are mediated via the IL‐6 membrane receptor, but probably also via agonistic soluble IL‐6 receptors (sIL‐6Rs).
Schöbitz, Bernd, Pezeshki, G., Pohl, Thomas M., Hemmann, Ulrike, Heinrich, Peter, Holsboer, Florian, Reul, J. M.   +6 more
openaire   +3 more sources

Chimeric molecule IL‐6/soluble IL‐6 receptor is a potent mitogen for fetal hepatocytes

Journal of Cellular Physiology, 2004
AbstractA novel recombinant molecule, termed IL‐6c and consisting of a chimera of interleukin 6 (IL‐6) and its soluble receptor is extremely potent in stimulating proliferation of hematopoietic progenitors. We investigated the effect of the IL‐6c on the proliferation and differentiation of E14 fetal hepatocytes.
Isabel, Zvibel, Shlomo, Brill, Revital, Kariv, Alexandra, Traister, Talia, Golan, Judith, Chebath, Zamir, Halpern, Michel, Revel, Ran, Oren   +8 more
openaire   +2 more sources

Role of IL-6 and the Soluble IL-6 Receptor in Inhibition of VCAM-1 Gene Expression

The Journal of Immunology, 1998
Abstract Adhesion molecules such as VCAM-1 and ICAM-1 are increased in the central nervous system (CNS) during inflammatory responses and contribute to extravasation of leukocytes across the blood-brain barrier (BBB) and into CNS parenchyma. Astrocytes contribute to the structural integrity of the BBB and can be induced to express VCAM-1
J W, Oh, N J, Van Wagoner, S, Rose-John, E N, Benveniste   +3 more
openaire   +2 more sources

Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia

European Archives of Psychiatry and Clinical Neuroscience, 1997
The cytokines interleukin-2 (IL-2) and interleukin-6 (IL-6) increase during immune activation, they are released from activated astrocytes and microglial cells in the central nervous system (CNS), and they are able to enhance the catecholaminergic neurotransmission. This study focused on the soluble receptors of IL-2 and IL-6 (sIL-2R, sIL-6R) as a part
N, Müller, M, Empl, M, Riedel, M, Schwarz, M, Ackenheil   +4 more
openaire   +2 more sources

URINARY SOLUBLE IL-6 RECEPTOR LEVELS AFTER CARDIOPULMONARY BYPASS

Cytokine, 2000
To investigate the possible role of soluble interleukin 6 receptor (sIL-6r) in the inflammatory response to cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC), we examined the levels of sIL-6r in the urine of 50 patients undergoing coronary artery bypass surgery.
Sutherland AG, Deehan DJ
openaire   +3 more sources

Alternative assay procedures for cytokines and soluble receptors of the IL-6 family

Journal of Immunological Methods, 1996
Human hepatoma cells (HepG2 cells) were transfected with expression vectors for human IL-6 (hIL-6) and rat IL-6R (rIL-6-R). The cell lines were used for testing the biological activity of different IL-6 species, soluble hIL-6R (shIL-6R) and some members of the IL-6 cytokine family by means of an ELISA procedure.
B, Oppmann, T, Stoyan, M, Fischer, N, Voltz, P, März, S, Rose-John   +5 more
openaire   +2 more sources

Endothelial Cell Protein S Synthesis Is Upregulated by the Complex of IL-6 and Soluble IL-6 Receptor

Thrombosis and Haemostasis, 1997
SummaryWe have recently demonstrated that the proinflammatory cytokine, interleukin-6 (IL-6), could upregulate the production of protein S in the human hepatoma cell line, HepG-2, but not in endothelial cells. In this study, we have demonstrated that the combination of exogenous IL-6 and soluble IL-6 receptor (sIL-6R) could significantly upregulate ...
W C, Hooper, D J, Phillips, B L, Evatt
openaire   +2 more sources

Effects of IL-6 and Soluble IL-6 Receptor on the Expression of Cartilage Matrix Proteins in Human Chondrocytes

Connective Tissue Research, 2007
Elevated concentrations of interleukin (IL)-6 and soluble IL-6 receptor (sIL-6Ralpha) in synovial fluid have been implicated in joint cartilage destruction. We examined the effect of IL-6 and sIL-6Ralpha on cell growth, alkaline phosphatase (ALPase) activity, and the expression of Sox-9, type II collagen, aggrecan core, link protein, BMP-7, and BMP ...
Aki, Namba, Yukiko, Aida, Naoto, Suzuki, Yusuke, Watanabe, Takayuki, Kawato, Masafumi, Motohashi, Masao, Maeno, Hideo, Matsumura, Mitsuhiko, Matsumoto   +8 more
openaire   +2 more sources

[The IL-6 soluble receptors in hemodialyzed patients].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2004
Pro-inflammatory cytokines, in addition to their role in host defence, can be considered a disease mediator; therefore, a reduction in cytokine synthesis or its effects is becoming a target of many diseases. Interleukin-6 (IL-6) is a pro-inflammatory cytokine that could play a role in several clinical problems related to dialysis treatment.
Memoli B, Soccio M, Procino A, Pertosa G., GRANDALIANO, GIUSEPPE   +4 more
openaire   +2 more sources

Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins

The Journal of Immunology, 1992
Abstract IL-6 is a major regulator of acute phase protein synthesis in the liver. It exerts its action via a plasma membrane receptor consisting of two subunits, a ligand binding 80-kDa glycoprotein and a 130-kDa glycoprotein involved in signal transduction. We genetically generated a soluble form of the 80-kDa subunit of the human IL-
Mackiewicz, Andrzej, Schooltink, Heidi, Heinrich, Peter, Rose-John, Stefan   +3 more
openaire   +2 more sources