Results 61 to 70 of about 819,741 (161)

Pyrophosphatase and DNA Polymerase activity of wt and site-specific variants of α subunit.

, 2016
A) Pyrophosphatase activity of 17 nM wt (green dots), 17 nM H12A (blue dots), or 13 nM D19A (red dots) α subunit. B,C) DNA Polymerase activity as determined in the presence (B) or in the absence of E. coli inorganic pyrophosphatase (C).
Massimiliano Lanzi (1463971), Perceval Vellosillo Gonzalez (2601454), Alejandro Hochkoeppler (2082769), Fabio Lapenta (2601445), Sofia Perticarari (2601448), Alejandro Montón Silva (2601451), Renato Brandimarti (617022), Fabio Lino Gratani (2601457)   +7 more
core   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Proton pumping inorganic pyrophosphatase of pea stem submitochondrial particles

, 1991
Pea stem submitochondrial particles have an inorganic pyrophosphatase (pyrophosphate phosphohydrolase, EC 3.6.1.1) which is able to couple PP(i) hydrolysis with the generation of an inside positive proton gradient.
ZANCANI, Marco, BRAIDOT, Enrico, PETRUSSA, Elisa, VIANELLO, Angelo, MACRI', Francesco Arturo   +4 more
core   +1 more source

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source

Metal Binding Sites in Plant Soluble Inorganic Pyrophosphatases. An Example of the Use of ROSETTA Design and Hidden Markov Models to Guide the Homology Modeling of Proteins

Journal of the Mexican Chemical Society, 2017
In contrast to their counterparts in bacteria and animals the soluble inorganic pyrophosphatases from plant cells are active as monomers. The isoforms 1 and 4 from Arabidopsis thaliana have been characterized with more detail, but their three-dimensional structure is unavailable.
Luis Rosales-León, Eric Edmundo Hernández-Domínguez, Samantha Gaytán-Mondragón, Rogelio Rodríguez-Sotres   +3 more
openaire   +3 more sources

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

The Role of the C-terminus in Bacillus subtilis inorganic pyrophosphatase activity [PDF]

, 2003
Inorganic pyrophosphatases hydrolyse inorganic pyrophosphate ensuring that the pool of phosphate is continuously available in a cell for subsequent metabolic reactions.
Konopka, Monika
core   +5 more sources

PHR1 mediates rapid high light responses and acclimation to high photosynthetic activity

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Changing light intensity requires immediate metabolic adjustment which involves reprogramming of both plastidial and nuclear gene expression, but the signaling pathways behind such responses are not fully understood. Here we report that an increase in light intensity causes fluctuations of Pi levels in the chloroplasts of Arabidopsis thaliana ...
Lukas Ackermann, Agnes Fekete, Laura Schröder, Thomas Nägele, Alina J. Hieber, Monika Müller, Martin J. Mueller, Maria Klecker   +7 more
wiley   +1 more source

Characterization of the Human Blood Group Glycosyltransferases GTA and GTB for the Synthesis of Blood Group Antigens

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
This study presents the highly efficient heterologous production of the human blood group glycosyltransferases GTA/R176A and GTB, along with their comprehensive biochemical and kinetic characterization. Tailored enzyme cascades, involving the bacterial fucosyltransferase FutC and GTA or GTB, generate milligram quantities of various blood group ABH ...
Katja Pöstges, Philip Palm, Kai P. Hussnaetter, Eliška Filipová, Helena Pelantová, Lucie Petrásková, Pavla Bojarová, Vladimír Křen, Lothar Elling   +8 more
wiley   +1 more source

Generation of inorganic pyrophosphate (PPi).

, 2012
PPi is produced by the hydrolysis of ATP into AMP in cells. Inorganic pyrophosphatase (PPA1) catalyzes the hydrolysis of PPi to form 2 orthophosphates (2Pi), resulting in energy release.
Young-Joo Yi (174190), Miriam Sutovsky (174199), Chelsey Kennedy (174206), Peter Sutovsky (174218)   +3 more
core   +1 more source