Results 41 to 50 of about 202,290 (315)

Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease.

Biochimica et biophysica acta. Molecular cell research, 2021
The pleiotropic cytokine interleukin-6 (IL-6) is involved in numerous physiological and pathophysiological functions that include development, immune cell differentiation, inflammation and cancer.
Tim Schumertl, J. Lokau, S. Rose-John, Christoph Garbers   +3 more
semanticscholar   +1 more source

Interleukin 6, soluble interleukin 2 receptor alpha (CD25), monocyte colony-stimulating factor, and hepatocyte growth factor linked with systemic hyperinflammation, innate immunity hyperactivation, and organ damage in COVID-19 pneumonia

Cytokine, 2021
Background Patients infected by SARS-CoV-2 can develop interstitial pneumonia, requiring hospitalisation or mechanical ventilation. Increased levels of inflammatory biomarkers are associated with development of acute respiratory distress syndrome (ARDS).
L. Quartuccio, M. Fabris, A. Sonaglia, M. Peghin, R. Domenis, A. Cifù, F. Curcio, C. Tascini   +7 more
semanticscholar   +1 more source

BODY IRON STATUS INDICATORS AND INFLAMMATION INDICATORS DURING INFLAMMATORY BOWEL DISEASE THERAPY IN CHILDREN AND ADOLESCENTES [PDF]

Arquivos de Gastroenterologia, 2021
BACKGROUND: The treatment of patients with inflammatory bowel disease (IBD) consists of the induction and maintenance remission of the disease. Iron status indicators would be useful for the diagnosis of iron deficiency anemia, whereas the inflammation ...
Fernanda F CORRÊA, Vera L SDEPANIAN
doaj   +1 more source

Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder

BMC Psychiatry, 2023
Background It has been hypothesized that the IL-6/sIL-6R/sgp130 complex, an inflammatory complex, plays a critical role in the pathogenesis of major depressive disorder (MDD).
Ting Sun, Qian Chen, Junchi Mei, Yan Li
doaj   +1 more source

Effects of the Interleukin-6 Receptor Blocker Sarilumab on Metabolic Activity and Differentiation Capacity of Primary Human Osteoblasts

Pharmaceutics, 2022
Interleukin (IL-) 6 is a key factor in the inflammatory processes of rheumatoid arthritis. Several biologic agents target the IL-6 signaling pathway, including sarilumab, a monoclonal antibody that blocks the IL-6 receptor and inhibits IL-6-mediated cis-
Annett Klinder, Janine Waletzko-Hellwig, Marie-Luise Sellin, Anika Seyfarth-Sehlke, Markus Wolfien, Franziska Prehn, Rainer Bader, Anika Jonitz-Heincke   +7 more
doaj   +1 more source

A case of autoimmune enteropathy with CTLA4 haploinsufficiency [PDF]

Intestinal Research, 2022
Autoimmune enteropathy (AIE) is a rare disease, characterized by intractable diarrhea, villous atrophy of the small intestine, and the presence of circulating anti-enterocyte autoantibodies. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked
Haruka Miyazaki, Namiko Hoshi, Michitaka Kohashi, Eri Tokunaga, Yuna Ku, Haruka Takenaka, Makoto Ooi, Nobuyuki Yamamoto, Suguru Uemura, Noriyuki Nishimura, Kazumoto Iijima, Keisuke Jimbo, Tsubasa Okano, Akihiro Hoshino, Kohsuke Imai, Hirokazu Kanegane, Ichiro Kobayashi, Yuzo Kodama   +17 more
doaj   +1 more source

A Potential Role of IL-6/IL-6R in the Development and Management of Colon Cancer

Membranes, 2021
Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise following somatic mutations, while about 10% are hereditary cancers caused by ...
Mimmo Turano, Francesca Cammarota, Francesca Duraturo, Paola Izzo, Marina De Rosa   +4 more
doaj   +1 more source

Role of Soluble Interleukin-6 Receptor With Interleukin-6 in Human Hematopoiesis

Hematology, 1997
A complex of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 has been shown to play some roles in human hematopoiesis. It activates gp130 signal to stimulate human erythroid, megakaryocytic and primitive hematopoietic progenitor cells, which express gp130 but not IL-6R, in the presence of c-Kit signal mediated by stem cell factor (SCF).
K, Tsuji, T, Nakahata
openaire   +2 more sources

Modification of Soluble Immunological Parameters during Treatment with Interleukin-2

The International Journal of Biological Markers, 1993
In the present study we tested numerous soluble immunological parameters (soluble Interleukin 2 receptor, Beta 2 microglobulin, Neopterin, soluble CD8 antigen, gamma Interferon and alpha Tumor Necrosis Factor) in sera obtained from 18 advanced cancer ...
I. Abbate, M. Correale, M.D. Musci, M. Guida, C.D. Dragone, M. De Santis, M. De Lena   +6 more
doaj   +1 more source

Role of interleukin-15 and interleukin-18 in the secretion of sIL-6R and sgp130 by human neutrophils

Mediators of Inflammation, 2003
Background: Available data indicate that neutrophils (PMN) produce a wide range of cytokines with the potential to modulate immune response. Recent investigation have shown that interleukin (IL)-15 and IL-18 potentiated several functions of normal ...
E. Jablonska, M. Marcinczyk
doaj   +1 more source