Results 91 to 100 of about 280,773 (255)

A source of the single stranded DNA substrate for activation-induced deaminase during somatic hypermutation

Nature Communications, 2014
During somatic hypermutation (SHM), activation-induced deaminase (AID) mutates deoxycytidine on single-stranded DNA (ssDNA) generated by the transcription machinery, but the detailed mechanism remains unclear.
Xiaohuan Wang, M. Fan, Susan L. Kalis, Lirong Wei, M. Scharff   +4 more
semanticscholar   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells

Journal of Experimental Medicine, 2014
Fanca contributes to both somatic hypermutation and class switch recombination events in splenic B cells.
T. Nguyen, L. Riou, S. Aoufouchi, F. Rosselli   +3 more
semanticscholar   +1 more source

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells

Nature Genetics, 2021
Brice Laffleur, Junghyun Lim, Wanwei Zhang, Yiyun Chen, Evangelos Pefanis, Jonathan Bizarro, Carolina Batista, Lijing Wu, A. Economides, Jiguang Wang, Uttiya Basu   +10 more
semanticscholar   +1 more source

Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo–activated cells

Journal of Experimental Medicine, 2014
Maul et al. show that proteins associated with variable gene hypermutation, such as Spt5 and AID, are recruited to the initiating form of RNA polymerase II specifically in cells activated in germinal centers but not in culture.
R. Maul, Zheng Cao, L. Venkataraman, C. Giorgetti, J. L. Press, Y. Denizot, H. Du, R. Sen, P. Gearhart   +8 more
semanticscholar   +1 more source

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

Cell Reports, 2014
Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs).
Xiang Chen, Armita Bahrami, Alberto Pappo, John Easton, James Dalton, Erin Hedlund, David Ellison, Sheila Shurtleff, Gang Wu, Lei Wei, Matthew Parker, Michael Rusch, Panduka Nagahawatte, Jianrong Wu, Shenghua Mao, Kristy Boggs, Heather Mulder, Donald Yergeau, Charles Lu, Li Ding, Michael Edmonson, Chunxu Qu, Jianmin Wang, Yongjin Li, Fariba Navid, Najat C. Daw, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Jinghui Zhang, Michael A. Dyer   +30 more
doaj   +1 more source

Checkpoint kinase 1 negatively regulates somatic hypermutation

Nucleic Acids Research, 2014
Immunoglobulin (Ig) diversification by somatic hypermutation in germinal center B cells is instrumental for maturation of the humoral immune response, but also bears the risk of excessive or aberrant genetic changes.
Samantha Frankenberger, Kathrin Davari, Sabine Fischer-Burkart, Katrin Böttcher, Nils-Sebastian Tomi, U. Zimber-Strobl, B. Jungnickel   +6 more
semanticscholar   +1 more source

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

Aging Cell, Volume 25, Issue 2, February 2026.
Hematopoietic aging arises from intrinsic stem‐cell decline and bone‐marrow niche dysfunction, leading to myeloid skewing, immunosenescence, and clonal hematopoiesis. These changes drive systemic inflammation and multi‐organ disease, which in turn further disrupt the bone‐marrow niche and hematopoietic stem cell (HSC) function, creating a vicious cycle
Masashi Miyawaki, Seiji Hashimoto, Sumito Ogawa, Yoshitaka Kase   +3 more
wiley   +1 more source

Teleost IgD+IgM− B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles

Cell Reports, 2019
Summary: Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD+IgM− plasmablasts constitute a major lymphocyte
Pedro Perdiguero, Alba Martín-Martín, Ottavia Benedicenti, Patricia Díaz-Rosales, Esther Morel, Estefanía Muñoz-Atienza, Mónica García-Flores, Rocío Simón, Irene Soleto, Andrea Cerutti, Carolina Tafalla   +10 more
doaj   +1 more source