Results 31 to 40 of about 7,600 (256)

Low cholesterol levels are good markers for central hypothyroidism in case with dialysis using roxadustat

Clinical Case Reports, Volume 12, Issue 9, September 2024.
Key Clinical Message Recently, hypoxia‐inducible factor prolyl hydroxylase (HIF‐PH) inhibitors have been used for renal anemia, but side effects have also been reported. We report on the association of central hypothyroidism and cholesterol with roxadustat.
Serina Kita, Hiroshi Okuyama, Takaya Kondo, Mizuki Hayashi, Shinichiro Nakao, Toshitaka Sawamura, Keiji Fujimoto, Atsushi Nakagawa, Hitoshi Yokoyama, Kengo Furuichi   +9 more
wiley   +1 more source

Proteomic exploration of potential blood biomarkers in haemophilic arthropathy

Health Science Reports, Volume 7, Issue 9, September 2024.
Abstract Background and Aims The pathophysiology of haemophilic arthropathy (HA) is complex and largely undefined. Proteomic analyses provide insights into the intricate mechanisms of the HA. Our study aimed to identify differentially expressed proteins in relation to the severity of HA, explore their pathophysiological roles, and evaluate their ...
Nataša Kalebota, Ruđer Novak, Stela Hrkač, Porin Perić, Grgur Salai, Marko Močibob, Marija Pranjić, Zbyněk Zdráhal, Václav Pustka, Nadica Laktašić Žerjavić, Milan Milošević, Marijo Vodanović, Silva Zupančić Šalek, Lovorka Grgurević   +13 more
wiley   +1 more source

Scale‐Dependent Rheology of Synovial Fluid Lubricating Macromolecules

Small, Volume 20, Issue 21, May 23, 2024.
A multiscale methodology using optical tweezers is developed to examine the interactions between hyaluronic acid (HA) and proteoglycan‐4 (PRG4/lubricin), which are major lubricating biomolecules of synovial fluid in the joints. For the first time, the length scale dependent structure and rheology in solution are characterized, providing a framework for
Leonardo Martin‐Alarcon, Aleksandra Govedarica, Randy H. Ewoldt, Steven L. Bryant, Gregory D. Jay, Tannin A. Schmidt, Milana Trifkovic   +6 more
wiley   +1 more source

Effects of glucocorticoids on growth and bone mineralization [PDF]

, 2011
OBJETIVO: Revisar os mecanismos de ações dos glicocorticoides e sua capacidade de induzir osteoporose e déficits de crescimento. FONTES DOS DADOS: A revisão bibliográfica de artigos científicos foi realizada na base de dados MEDLINE e utilizou as ...
DONATTI, Teresinha Lermen, KOCH, Vera Hermina Kalika, PEREIRA, Rosa Maria Rodrigues, TAKAYAMA, Liliam   +3 more
core   +2 more sources

Proteoglycan 4 (PRG4) treatment improves skin wound healing in a porcine model

The FASEB Journal, Volume 38, Issue 6, 31 March 2024.
Proteoglycan 4 (PRG4) is commonly found in synovial fluid of the articular joint and serves as a boundary lubricant of articular cartilage. Interestingly, we show that human recombinant proteoglycan 4 (rhPRG4) improves healing of porcine full‐thickness skin injuries. rhPRG4 treatment decreases fibrosis, increases vascularization, and retains adipocytes
Nicoletta Ninkovic, Holly D. Sparks, Dragana Ponjevic, Greg Muench, Jeff A. Biernaskie, Roman J. Krawetz   +5 more
wiley   +1 more source

Advances in the Use of Biologics and Biomaterials toward the Improvement of Pancreatic Islet Graft Survival in Type 1 Diabetes

Advanced NanoBiomed Research, Volume 4, Issue 3, March 2024.
Although islet transplantation has the potential to serve as a curative treatment for type 1 diabetes, there are many hurdles to achieving long‐term islet graft survival. This review discusses the recent advances in strategies to improve islet survival function using exogenous compounds and conformal coatings as a promising tool for improving islet ...
Michael Yilma Yitayew, Marina Luginina, Maryam Tabrizian   +2 more
wiley   +1 more source

The biophysical and compositional properties of human basement membranes

The FEBS Journal, Volume 291, Issue 3, Page 477-488, February 2024.
Basement membranes are exceptionally adaptable materials with both extremely stiff and highly elastic properties. This article highlights these features on a selection of human membranes and links them to compositional, biomechanical, and structural profiles down to a molecular level. The role of water in modulating these attributes is also scrutinized
Monica S. Schoenenberger, Willi Halfter, Alexia Ferrand, Kathrin Halfter, Alexandar Tzankov, Hendrik P. N. Scholl, Paul Bernhard Henrich, Christophe A. Monnier   +7 more
wiley   +1 more source

A hundred years of the hepatotrophic controversy. [PDF]

, 1977
Venous blood returning from the splanchnic viscera has liver-supporting (hepatotrophic) qualities not found to the same degree in other kinds of arterial or venous blood.
Benichou, J, Francavilla, JA, Porter, KA, Putnam, CW, Starzl, TE   +4 more
core  

Quantification of insulin‐like growth factor‐I by liquid chromatography–mass spectrometry

Rapid Communications in Mass Spectrometry, Volume 38, Issue S1, January 2024.
We describe three methods of sample preparation for the liquid chromatography coupled with mass spectrometric measurement of insulin‐like growth factor‐I concentration in blood. One method involves trypsin digestion, the second involves intact protein quantification and the third method is a combination of the first two.
Danielle A. Moncrieffe, David A. Cowan
wiley   +1 more source

Molecular crosstalk between insulin‐like growth factors and follicle‐stimulating hormone in the regulation of granulosa cell function

Reproductive Medicine and Biology, Volume 23, Issue 1, January/December 2024.
Crosstalk between insulin‐like growth factors and follicle‐stimulating hormone in the regulation of ovarian antral follicles. Abstract Background The last phase of folliculogenesis is driven by follicle‐stimulating hormone (FSH) and locally produced insulin‐like growth factors (IGFs), both essential for forming preovulatory follicles.
Emily Hayes, Nicola Winston, Carlos Stocco   +2 more
wiley   +1 more source