Results 91 to 100 of about 170,108 (362)

Distinct Alterations of Inflammatory Biomarkers in Cluster Headache: A Case Control Study

Annals of Neurology, EarlyView.
Objective Investigate the immune system's role in cluster headache by analyzing cytokines in people with cluster headache and headache‐free controls, and explore if certain cytokines could predict a specific phenotype. Methods We measured 45 cytokines in adult participants from the Danish Cluster Headache Biobank in a prospective case–control setup ...
Nunu Laura Timotheussen Lund, Connar Stanley James Westgate, Marie‐Louise Kulas Søborg, Agneta Henriette Snoer, Rigmor Højland Jensen, Thomas Folkman Hansen, Anja Sofie Petersen   +6 more
wiley   +1 more source

Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paltusotine is a novel, nonpeptide, selective somatostatin receptor 2 agonist in development for the treatment of acromegaly and carcinoid syndrome. This study investigated the mass balance, routes of excretion, absolute bioavailability and metabolite profile of orally administered paltusotine.
Rosa Luo, Ajay Madan, Christine T. Ferrara‐Cook, Deepak Dalvie, Lance Goulet, R. Scott Struthers, Alan S. Krasner   +6 more
wiley   +1 more source

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

Proceedings of the National Academy of Sciences of the United States of America, 1986
We have examined the regulation of somatostatin gene expression by cAMP in PC12 rat pheochromocytoma cells transfected with the rat somatostatin gene. Forskolin at 10 microM caused a 4-fold increase in somatostatin mRNA levels within 4 hr of treatment in
M. Montminy, K. Sevarino, John A. Wagner, G. Mandel, R. Goodman   +4 more
semanticscholar   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Development of extrahepatic bile ducts and mechanisms of tumorigenesis: Lessons from mouse models

Pathology International, Volume 72, Issue 12, Page 589-605, December 2022., 2022
Abstract The biliary system is a highly branched tubular network consisting of intrahepatic bile ducts (IHBDs) and extrahepatic bile ducts (EHBDs). IHBDs are derived from hepatic progenitor cells, while EHBDs originate directly from the endoderm through a separate branching morphogenetic process.
Hiroyuki Tomita, Akira Hara
wiley   +1 more source

Somatostatin Neurons in the Basal Forebrain Promote High-Calorie Food Intake

Cell Reports, 2017
Obesity has become a global issue, and the overconsumption of food is thought to be a major contributor. However, the regulatory neural circuits that regulate palatable food consumption remain unclear.
Chen Zhu, Yun Yao, Yan Xiong, Mingxiu Cheng, Jing Chen, Rui Zhao, Fangzhou Liao, Runsheng Shi, Sen Song   +8 more
doaj   +1 more source

Somatostatin-Mediated Regulation of Retinoic Acid-Induced Differentiation of SH-SY5Y Cells: Neurotransmitters Phenotype Characterization

Biomedicines, 2022
During brain development, neurite formation plays a critical role in neuronal communication and cognitive function. In the present study, we compared developmental changes in the expression of crucial markers that govern the functional activity of ...
Sneha Singh, Rishi K. Somvanshi, Ujendra Kumar   +2 more
doaj   +1 more source

Somatostatin agonist pasireotide inhibits exercise stimulated growth in the male Siberian hamster (Phodopus sungorus) [PDF]

, 2017
R.Dumbell was supported by a University of Aberdeen PhD studentship and a research visit grant awarded by the British Society of Neuroendocrinology. Further support was provided by the Scottish Government Rural and Environment Science and Analytical ...
Barrett, P, Diedrich, V, Dumbell, R, Petri, I, Scherbarth, F, Schmid, H A, Steinlechner, S   +6 more
core   +2 more sources

Tryptophan‐Selective Chemical Modification of Peptides by Thioether‐Mediated Sulfenylation

ChemistryEurope, EarlyView.
A thioether‐mediated sulfenylation method based on 4‐fluorophenyl 3‐nitro‐2‐pyridinesulfenate (Npys‐OPh(pF)) is developed for Trp‐selective chemical modification. This sulfenylation proceeds under mild, metal‐free, and weakly acidic conditions and is broadly applicable to the chemical modification of various Trp‐containing peptides as well as the late ...
Hayate Shida, Akihiro Taguchi, Yuma Tokita, Yan Cui, Momoka Sakamaki, Sho Konno, Atsuhiko Taniguchi, Young Sook Yun, Yuuta Fujikawa, Hiroshi Kaneko, Hidemasa Nakaminami, Yoshio Hayashi   +11 more
wiley   +1 more source

Retrospective study of 20 cats surgically treated for insulinoma

Veterinary Surgery, Volume 52, Issue 1, Page 42-50, January 2023., 2023
Abstract Objective To report the clinical signs, histopathology results, and prognostic factors for outcomes following excision for feline insulinoma (INS). Study design Retrospective study. Sample population Twenty client‐owned cats. Methods Medical records from 2006 to 2020 were reviewed by Veterinary Society of Surgical Oncology members for cats ...
Stan Veytsman, Pierre Amsellem, Brian D. Husbands, Aaron K. Rendahl, Philip J. Bergman, Guillaume Chanoit, Colleen Hickey, Kristy R. Cash, Karl C. Maritato, Francesco Collivignarelli, Jolle Kirpensteijn   +10 more
wiley   +1 more source