Results 131 to 140 of about 179,431 (364)
Somatostatin/somatostatin receptor signalling: Phosphotyrosine phosphatases [PDF]
Molecular and Cellular Endocrinology, 2008 Activation of phosphotyrosine phosphatases (PTPs) by somatostatin receptor (SSTR) represents one of the main intracellular mechanisms involved in the antiproliferative effect of somatostatin (SST) and analogues. Since their molecular cloning, the role of PTPs is emerging as a major regulator of different cell functions including cell proliferation ...
openaire +4 more sources
Epilepsia, EarlyView.Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim +6 more
wiley +1 more source
Primary Structure of Somatostatin, A Hypothalamic Peptide That Inhibits the Secretion of Pituitary Growth Hormone [PDF]
, 1973 Roger Burgus +3 more
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Synchronous primary papillary breast cancer, medullary thyroid carcinoma and neuroendocrine tumor in postmenopausal woman. [PDF]
, 2016 Multiple endocrine neoplasia are syndromes involving two or more endocrine tissues, often correlated to RET proto-oncogene mutations. We herein present the first reported case of a 57-years-old woman with three synchronous primary cancers of breast ...
DE IULIIS, Francesca +7 more
core
Epilepsia, EarlyView.Abstract This study was undertaken to systematically evaluate the efficacy of cell therapy in reducing seizures in animal models of chronic epilepsy. Three databases, Ovid MEDLINE, Ovid Embase, and Web of Science, were searched using predetermined eligibility criteria.
Afaf S. Altalhi +6 more
wiley +1 more source
Zeitschrift für Naturforschung B, 1980 The total synthesis of the octacosapeptide corresponding to the proposed primary structure of porcine somatostatin-28, a possible precursor of somatostatin, is described. The primary structure of somatostatin-28 corresponds to that of somatostatin elongated at the N-terminus by a tetradecapeptide sequence.
Lucien Pradayrol +6 more
openaire +2 more sources
Epilepsia, EarlyView.Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Samantha L. Reed +8 more
wiley +1 more source
Use of octadecasilyl-silica for the extraction and purification of peptides in biological samples. Application to the identification of circulating metabolites of corticotropin-(1-24)-tetracosapeptide and somatostatin in vivo [PDF]
, 1977 H.P.J. Bennett +3 more
openalex +1 more source
Neocortical neurogenesis: a proneural gene perspective
The FEBS Journal, EarlyView.The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan +3 more
wiley +1 more source
The use of octreotide in pediatric patients: Practical applications for gastrointestinal disorders and beyond: A narrative review. [PDF]
Nutr Clin PractAbstract Somatostatin is a naturally occurring polypeptide hormone that exerts its effect on the gastrointestinal tract by reducing exocrine and endocrine secretion, resulting in decreased motility, gastric emptying, splanchnic blood flow, fat absorption, lymphatic flow, and gallbladder contraction.
Dunn B +4 more
europepmc +2 more sources