Results 51 to 60 of about 68,999 (229)
Animals, 2022 Animal growth traits are directly linked with the economics of livestock species. A somatostatin DNA vaccine has been developed to improve the growth of animals. However, the growth-promoting effect is still unsatisfying.
Xuan Luo +9 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Paltusotine is a novel, nonpeptide, selective somatostatin receptor 2 agonist in development for the treatment of acromegaly and carcinoid syndrome. This study investigated the mass balance, routes of excretion, absolute bioavailability and metabolite profile of orally administered paltusotine.
Rosa Luo +6 more
wiley +1 more source
Somatostatin and Somatostatin-Containing Interneurons—From Plasticity to Pathology
Biomolecules, 2022 Despite the obvious differences in the pathophysiology of distinct neuropsychiatric diseases or neurodegenerative disorders, some of them share some general but pivotal mechanisms, one of which is the disruption of excitation/inhibition balance.
Monika Liguz-Lecznar +2 more
doaj +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Development of extrahepatic bile ducts and mechanisms of tumorigenesis: Lessons from mouse models
Pathology International, Volume 72, Issue 12, Page 589-605, December 2022., 2022 Abstract The biliary system is a highly branched tubular network consisting of intrahepatic bile ducts (IHBDs) and extrahepatic bile ducts (EHBDs). IHBDs are derived from hepatic progenitor cells, while EHBDs originate directly from the endoderm through a separate branching morphogenetic process.
Hiroyuki Tomita, Akira Hara
wiley +1 more source
Pathophysiology of GPCR Homo- and Heterodimerization: Special Emphasis on Somatostatin Receptors
Pharmaceuticals, 2012 G-protein coupled receptors (GPCRs) are cell surface proteins responsible for translating >80% of extracellular reception to intracellular signals.
Rishi K. Somvanshi, Ujendra Kumar
doaj +1 more source
Pharmaceutics, 2023 (1) Background: Hydrophobicity (or lipophilicity) is a limiting factor in the ability of molecules to pass through cell membranes and to perform their function.
Dancho Danalev +8 more
doaj +1 more source
Tryptophan‐Selective Chemical Modification of Peptides by Thioether‐Mediated Sulfenylation
ChemistryEurope, EarlyView.A thioether‐mediated sulfenylation method based on 4‐fluorophenyl 3‐nitro‐2‐pyridinesulfenate (Npys‐OPh(pF)) is developed for Trp‐selective chemical modification. This sulfenylation proceeds under mild, metal‐free, and weakly acidic conditions and is broadly applicable to the chemical modification of various Trp‐containing peptides as well as the late ...
Hayate Shida +11 more
wiley +1 more source
Retrospective study of 20 cats surgically treated for insulinoma
Veterinary Surgery, Volume 52, Issue 1, Page 42-50, January 2023., 2023 Abstract Objective To report the clinical signs, histopathology results, and prognostic factors for outcomes following excision for feline insulinoma (INS). Study design Retrospective study. Sample population Twenty client‐owned cats. Methods Medical records from 2006 to 2020 were reviewed by Veterinary Society of Surgical Oncology members for cats ...
Stan Veytsman +10 more
wiley +1 more source
Slovenian Veterinary Research, 2023 The pancreas is a complex gland that possesses both endocrine and exo-crine functions. The present study investigated the gross anatomy, histochemical fea-tures, and immunohistochemical expression of insulin, glucagon, somatostatin, and pancreatic ...
Ahmed Abdellatif
doaj +1 more source