225Ac-Labeled Somatostatin Analogs in the Management of Neuroendocrine Tumors: From Radiochemistry to Clinic [PDF]
Pharmaceutics, 2023 The widespread use of peptide receptor radionuclide therapy (PRRT) represents a major therapeutic breakthrough in nuclear medicine, particularly since the introduction of 177Lu-radiolabeled somatostatin analogs. These radiopharmaceuticals have especially
Léa Rubira +4 more
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Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy [PDF]
Molecules, 2020 Identified in 1973, somatostatin (SST) is a cyclic hormone peptide with a short biological half-life. Somatostatin receptors (SSTRs) are widely expressed in the whole body, with five subtypes described. The interaction between SST and its receptors leads
Romain Eychenne +5 more
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Treatment with somatostatin analogs induces differentially expressed let-7c-5p and mir-3137 in small intestine neuroendocrine tumors [PDF]
BMC Cancer, 2019 Background Distant metastases frequently occur in gastroenteropancreatic neuroendocrine tumors. If hepatic surgery is not feasible, patients are treated with somatostatin analogs.
Florian Bösch +10 more
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Radiolabeled Somatostatin Analogs-A Continuously Evolving Class of Radiopharmaceuticals. [PDF]
Cancers (Basel), 2022 Simple Summary Somatostatin receptors (SSTs) are of particular interest in oncology because these proteins are overexpressed on the cell membranes of different human malignancies, especially neuroendocrine tumors (NETs) and neuroendocrine neoplasms (NENs)
Fani M, Mansi R, Nicolas GP, Wild D.
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Frontiers in Endocrinology, 2021 Neuroendocrine tumors overexpress somatostatin receptors, which serve as important and unique therapeutic targets for well-differentiated advanced disease.
Mayank Patel +5 more
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Somatostatin analogs: Clinical application in relation to human somatostatin receptor subtypes [PDF]
Biochemical Pharmacology, 1995 Although in situ hybridization has been used to examine the distribution of messenger RNA for somatostatin receptor subtypes (sst) in human tumors, the cellular localization of sst1 and sst2A receptors has not been ...
Hofland, L.J. (Leo) +2 more
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Somatostatin Analogs in Clinical Practice: a Review. [PDF]
Int J Mol Sci, 2020 Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of somatotropinomas, thyrotropinomas, and functioning and non-functioning gastroenteropancreatic neuroendocrine tumors.
Gomes-Porras M +2 more
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Insights into Structure-Activity Relationships of Somatostatin Analogs Containing Mesitylalanine [PDF]
Molecules, 2013 The non-natural amino acid mesitylalanine (2,4,6-trimethyl-L-phenylalanine; Msa) has an electron-richer and a more conformationally restricted side-chain than that of its natural phenylalanine counterpart.
Pablo Martín-Gago +12 more
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EJNMMI Research, 2018 Background Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs.
Silvia Taralli +7 more
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A case of malignant insulinoma responsive to somatostatin analogs treatment [PDF]
BMC Endocrine Disorders, 2018 Background Insulinoma is a rare tumour representing 1–2% of all pancreatic neoplasms and it is malignant in only 10% of cases. Locoregional invasion or metastases define malignancy, whereas the dimension (> 2 cm), CK19 status, the tumor staging and ...
Mariasmeralda Caliri +9 more
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