Human β‐Cell Dedifferentiation and Diabetes
Journal of Diabetes, Volume 18, Issue 10, October 2026.Human β‐cell dedifferentiation is inversely associated with HOMA‐β and occurs in Type 2 diabetes, Type 3c diabetes, and age‐related diabetes, potentially before hyperglycemia develops. Progressive loss of β‐cell identity is accompanied by dedifferentiation and transdifferentiation, suggesting that reversing these cell‐state changes may help restore ...
Jiajun Sun, Jinsook Son, Qidi Wang
wiley +1 more source
The effects of somatostatin analogs on mortality and quality of life in acromegaly
, 2010 Background Acromegaly is a disease characterized by growth hormone excess. It is associated with increased mortality and impaired quality of life. The treatment of choice is transsphenoidal surgery, but often surgical curation is not achieved. In case of
Postma, M.R.
core
A Real-World Observational Study of the Use and Associated Costs of Treating Neuroendocrine Tumors With Somatostatin Analogs in Canada. [PDF]
Pancreas, 2022 Cheung WY +4 more
europepmc +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Aging induces hyperglucagonemia through direct effects on pancreatic α‐cells or indirect systemic effects. This correlates with increased α‐cell mass as well as various alterations in α‐cell identity and function, which are exacerbated in the context of insulin resistance.
Eva Tudurí +17 more
wiley +1 more source
The Antiproliferative Activity of High-Dose Somatostatin Analogs in Gastro-Entero-Pancreatic Neuroendocrine Tumors: A Systematic Review and Meta-Analysis. [PDF]
J Clin Med, 2022 Panzuto F +7 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó +14 more
wiley +1 more source
Efficacy of cabergoline add-on therapy in patients with acromegaly resistance to somatostatin analogs treatment and the review of literature. [PDF]
Arch Endocrinol Metab, 2022 Kizilgul M +9 more
europepmc +1 more source
Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm
British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley +1 more source
Cancer Science, Volume 117, Issue 10, Page 2619-2635, October 2026.Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe +5 more
wiley +1 more source
Complete remission of recurrent multiple insulin-producing neuroendocrine tumors of the pancreas with somatostatin analogs: a case report and literature review. [PDF]
Discov Oncol, 2022 Tartaglia A +5 more
europepmc +1 more source