Results 121 to 130 of about 43,726 (267)

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Figure S5 from A Somatostatin Receptor Subtype-3 (SST₃) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors [PDF]

, 2023
Mari C. Vázquez‐Borrego, Vandana Gupta, Alejandro Ibáñez‐Costa, Manuel D. Gahete, Eva Venegas‐Moreno, Álvaro Toledano-Delgado, David A. Cano, Cristóbal Blanco-Acevedo, Rosa Ortega‐Salas, Miguel Á. Japón, Ana Barrera-Martín, Alexandre Vasiljevic, Jason Hill, Shengwen Zhang, Heather Halem, Juan Solivera, Gérald Raverot, María A. Gálvez, Alfonso Soto‐Moreno, Marcelo Páez-Pereda, Michael D. Culler, Justo P. Castaño, Raúl M. Luque   +22 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

Lu-177 Labeled Somatostatin Receptors and PSMA Dosimetry [PDF]

Türkay Toklu, Burcu Kozanlılar, Nami Yeyin, Tuğba Hacıosmanoğlu, Mustafa Demır, Sena Zeynep Usta   +5 more
openalex   +1 more source

Medial Septal GABAergic Neurons Express the Somatostatin sst_2AReceptor: Functional Consequences on Unit Firing and Hippocampal Theta [PDF]

, 2005
Marie‐Hélène Bassant, Axelle Simon, Frédérique Poindessous‐Jazat, Zsolt Csaba, Jacques Epelbaum, Pascal Dournaud   +5 more
openalex   +1 more source

Preoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Somatotroph tumors, a rare subtype of pituitary adenomas, can be histologically classified into sparsely granulated (SGSTs) and densely granulated somatotroph tumors (DGSTs) based on cytokeratin staining. SGSTs are generally more invasive and less responsive to medical therapy, making their early identification clinically important.
Le Chen, Jiaming Wang, Ailiang Zeng, Farhana Akter, Shanshan Wang, Shitong Liu, Weiyu Hu, Shun Yao, Konstantinos Margetis, Zongming Wang, Haipeng Liu, Xin Wang   +11 more
wiley   +1 more source

Ultraviolet A radiation induces cortistatin overexpression and activation of somatostatin receptors in ARPE‑19 cells

, 2018
Maria Elisabetta Clementi, Beatrice Sampaolese, Giacomo Lazzarino, Giuseppe Tringali   +3 more
openalex   +2 more sources

From Struggling (With) Screening Tests to Mouse Models of Depression‐Relevant Neurobehavioral States

Current Protocols, Volume 6, Issue 2, February 2026.
Abstract A major, serendipitous psychiatric discovery is monoamine‐transporter reuptake inhibition as an antidepressant mechanism of action. Chronic treatment with such antidepressants is efficacious, with onset requiring 1‐2 weeks, in many but by no means all patients with major depressive or another stress‐related neuropsychiatric disorder.
Christopher R. Pryce
wiley   +1 more source

Quad‐SPIM: A High‐Speed, Multi‐Color Light‐Sheet Microscope for 3D Imaging of Large Cleared Human Brain Tissues

Laser &Photonics Reviews, Volume 20, Issue 3, 5 February 2026.
A high‐speed, multi‐color light‐sheet microscope, named quad‐SPIM, enables rapid three dimensional (3D) imaging of large cleared human brain samples with simultaneous four‐channel acquisition. This custom‐built system achieves subcellular resolution across centimeter‐scale volumes, maintaining high image quality.
Laura Perego, Franco Cheli, Samuel Bradley, Danila Di Meo, Luca Giannoni, Josephine Ramazzotti, Federica Fenizi Caria, Giuseppe Sancataldo, Michele Sorelli, Giacomo Mazzamuto, Irene Costantini, Francesco Saverio Pavone   +11 more
wiley   +1 more source