Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin [PDF]
Guisheng Zhou +10 more
openalex +1 more source
18F-Labeled Somatostatin Analogs as PET Tracers for the Somatostatin Receptor: Ready for Clinical Use [PDF]
Hannes Leupe +7 more
openalex +1 more source
Lifespan‐Extending Endogenous Metabolites
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley +1 more source
Glutamate Delta 1 Receptor in Synapses, Circuits, and Disease
This review discusses our current understanding of the structure–function, expression and roles in neural circuits of the less studied glutamate delta 1 (GluD1) receptor. Converging data suggests many unique features of GluD1 including expression at both excitatory and inhibitory synapses and binding to D‐serine and GABA.
Diane Choi +3 more
wiley +1 more source
sst2 Somatostatin Receptor Mediates Cell Cycle Arrest and Induction of p27 [PDF]
Philippe Pagès +8 more
openalex +1 more source
Astrocyte Regulation of Spinal Circuit Function
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff +2 more
wiley +1 more source
Expression of somatostatin receptors, dopamine D2 receptors, noradrenaline transporters, and vesicular monoamine transporters in 52 pheochromocytomas and paragangliomas [PDF]
Alexandru Saveanu +10 more
openalex +1 more source
Ex vivo brain slice preparation is a popular technique in neuroscience research with many variations in preparation method. We compared two popular variations in brain slice preparation and found that the choice of brain slice preparation technique significantly affects the viability of neuronal preparation.
Felix Chan +12 more
wiley +1 more source
Determinants of incidence trends in pancreatic neuroendocrine neoplasms
Abstract The incidence of pancreatic neuroendocrine neoplasms (NENs) is rising; whether this reflects a true increase in disease occurrence or improved detection remains uncertain. We conducted a retrospective, population‐based study using data from the Surveillance, Epidemiology, and End Results (SEER) Program (1975–2021) to examine temporal trends in
Giuseppe Lamberti +5 more
wiley +1 more source

