Results 191 to 200 of about 2,397,304 (343)

In vivo monitoring of a cAMP-stimulated DNA-binding activity [PDF]

, 1990
Boshart, Michael, Nitsch, Doris, Schlitz, Günther, Stewart, A. F., Weih, Falk   +4 more
core   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science, Volume 12, Issue 41, November 6, 2025.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
wiley   +1 more source

Role of somatostatin receptor 2 (SSTR2) in pituitary adenomas. [PDF]

Clin Transl Med
Power Y, Liu J, Rehman U, Kjerimi A, Schartinger V, Counsell N, Starup-Hansen J, Newall N, Lund VJ, Mohyeldin A, Fernandez-Miranda JC, Lavezo J, Patel ZM, Nayak JV, Hwang PH, Brandner S, Marcus H, West RB, Lechner M.   +18 more
europepmc   +1 more source

Expression Analysis of Dopamine Receptor Subtypes in Normal Human Pituitaries, Nonfunctioning Pituitary Adenomas and Somatotropinomas, and the Association between Dopamine and Somatostatin Receptors with Clinical Response to Octreotide-LAR in Acromegaly [PDF]

, 2009
Leonardo Vieira Neto, Ednildo A. Machado, Raúl M. Luque, Giselle Fernandes Taboada, Jorge B Marcondes, Leila Chimelli, Leonardo Pereira Quintella, Paulo Niemeyer, Denise Pires de Carvalho, Rhonda D. Kineman, Mônica R. Gadelha   +10 more
openalex   +1 more source

Cerebrospinal fluid proteins in relation to longitudinal cognitive trajectories

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION We investigated longitudinal cognitive trajectories in relation to cerebrospinal fluid (CSF) proteomics in Alzheimer's disease (AD). METHODS Differential protein abundance analysis of proteomics (SomaScan 7K) data was performed for composite scores for domain‐specific cognitive functions (memory [MEM], executive function [EF], and
Bo‐Hyun Kim, Sang Won Seo, JunPyo Kim, Kwangsik Nho, for the Alzheimer's Disease Neuroimaging Initiative#   +4 more
wiley   +1 more source

"Not All That Glitters Is Gold": Paraspinal Cavernous Hemangioma Mimicking Paraganglioma on Somatostatin Receptor PET/CT. [PDF]

Diagnostics (Basel)
Iacovitti CM, Cabrilo I, Martinello C, Cuzzocrea M, Paone G, Treglia G.   +5 more
europepmc   +1 more source

J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine [PDF]

Andy Kuo, Mohammad Zafar Imam, R. Li, Li Lin, A. Raboczyj, Ana Elisa Böhmer, Janet R. Nicholson, Laura Corradini, Maree T. Smith   +8 more
openalex   +1 more source

The human somatostatin receptor type 2 as an imaging and suicide reporter gene for pluripotent stem cell-derived therapy of myocardial infarction [PDF]

, 2018
Katrien Neyrinck, Natacha Breuls, Bryan Holvoet, Wouter Oosterlinck, Esther Wolfs, H Vanbilloen, Olivier Gheysens, Robin Duelen, Willy Gsell, Ivo Lambrichts, Uwe Himmelreich, Catherine M. Verfaillie, Maurilio Sampaolesi, Christophe M. Deroose   +13 more
openalex   +1 more source

Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid-beta degrading enzyme in brain [PDF]

, 2020
Per Nilsson, Karin Sörgjerd, Naomasa Kakiya, Hiroki Sasaguri, Naoto Watamura, Makoto Shimozawa, Satoshi Tsubuki, Zhulin Zhou, Raúl Loera‐Valencia, Risa Takamura, Misaki Sekiguchi, Aline Petrich, Stefan Schulz, Takashi Saito, Bengt Winblad, Takaomi C. Saido   +15 more
openalex   +1 more source

Vasoactive neuropeptide dysregulation: A novel mechanism of microvascular dysfunction in vascular cognitive impairment

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Neuropeptide dysregulation and microvascular injury are involved in pathogenesis of vascular cognitive impairment (VCI); however, the underlying etiology of this pathological axis remains unclear. METHODS We investigated pathological mediators across varying severities of VCI in a rat model of chronic cerebral hypoperfusion (CCH).
Willians Tambo, Keren Powell, Steven Wadolowski, Prashin Unadkat, Eric H. Chang, Christopher LeDoux, Daniel Sciubba, Ping Wang, Patricio Huerta, Chunyan Li   +9 more
wiley   +1 more source