Results 81 to 90 of about 43,726 (267)
Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach
The Chemical Record, EarlyView.This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos +3 more
wiley +1 more source
Somatostatin receptor scintigraphy with 68Ga-DOTATATE PET/CT: initial experience in Cuba
Nucleus, 2017 In 1870, Rudolf Heidenhain discovered neuroendocrine cells, which can lead to the development of the Neuroendocrine Tumors (NER), a rare form of cancer, most of which express somatostatin receptors.
Juan P. Oliva González
doaj
Circulating hsa-miR-5096 predicts 18F-FDG PET/CT positivity and modulates somatostatin receptor 2 expression: a novel miR-based assay for pancreatic neuroendocrine tumors [PDF]
, 2023 Martine Bocchini +13 more
openalex +1 more source
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology, EarlyView.Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey +3 more
wiley +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim +6 more
wiley +1 more source
Signaling Can Be Uncoupled from Imaging of the Somatostatin Receptor Type 2
Molecular Imaging, 2007 Endogenous and exogenous somatostatin receptors are commonly targeted for imaging using radiopharmaceutical analogues of somatostatin. Ligand binding activates receptor-mediated signaling.
Lin Han, Dan Yang, Vikas Kundra
doaj +1 more source
Somatostatinergic systems: an update on brain functions in normal and pathological aging
Frontiers in Endocrinology, 2012 Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory and cognitive processes. Five somatostatin receptors have been described: sst1, sst2 (A and B), sst3 to 5, all belonging to
Guillaume eMartel +7 more
doaj +1 more source
Epilepsia, EarlyView.Abstract This study was undertaken to systematically evaluate the efficacy of cell therapy in reducing seizures in animal models of chronic epilepsy. Three databases, Ovid MEDLINE, Ovid Embase, and Web of Science, were searched using predetermined eligibility criteria.
Afaf S. Altalhi +6 more
wiley +1 more source
Regulation of Insulin Secretion Through Long‐Chain Fatty Acid Receptors
iNew Medicine, EarlyView.
Stefan Offermanns
wiley +1 more source