Results 131 to 140 of about 31,554 (221)

Impact of Neuroendocrine Neoplasm-Specific Systemic Treatments on Somatostatin Receptors Expression and Function in Neuroendocrine Tumor Cells. [PDF]

Cancers (Basel)
Däubler C, Böttcher C, Landwehr LS, Hartrampf PE, Meining A, Werner RA, Zhi Y, Kimpel O, Kloock S, Dischinger U, Weich A, Rogoll D.   +11 more
europepmc   +1 more source

Somatostatin Receptors and Chemokine Receptor CXCR4 in Lymphomas: A Histopathological Review of Six Lymphoma Subtypes. [PDF]

Front Oncol, 2021
Juntikka T, Vaittinen S, Vahlberg T, Jyrkkiö S, Minn H.   +4 more
europepmc   +1 more source

Human β‐Cell Dedifferentiation and Diabetes

Journal of Diabetes, Volume 18, Issue 10, October 2026.
Human β‐cell dedifferentiation is inversely associated with HOMA‐β and occurs in Type 2 diabetes, Type 3c diabetes, and age‐related diabetes, potentially before hyperglycemia develops. Progressive loss of β‐cell identity is accompanied by dedifferentiation and transdifferentiation, suggesting that reversing these cell‐state changes may help restore ...
Jiajun Sun, Jinsook Son, Qidi Wang
wiley   +1 more source

Aging Affects Pancreatic α‐Cell Function and Promotes Hyperglucagonemia: Implications in Age‐Associated Diabetes

Aging Cell, Volume 25, Issue 10, October 2026.
Aging induces hyperglucagonemia through direct effects on pancreatic α‐cells or indirect systemic effects. This correlates with increased α‐cell mass as well as various alterations in α‐cell identity and function, which are exacerbated in the context of insulin resistance.
Eva Tudurí, Lucía Almagro, Ana Ojeda‐Rodríguez, Raquel Pascua‐Maestro, Henver S. Brunetta, Sergi Soriano, Alejandro López‐Moreno, Talía Boronat‐Belda, Sergio Velasco‐Avilés, Joel Alves da Silva Junior, Manuel Castellano‐Muñoz, Alex Rafacho, Irene Cózar‐Castellano, Ángel Nadal, Paloma Alonso‐Magdalena, Beatriz Merino, José López‐Miranda, Ivan Quesada   +17 more
wiley   +1 more source

Somatostatin receptors 3 and 5 potentiate cholinergic-nerve-mediated contraction in human bronchus. [PDF]

Front Pharmacol
Brollo M, Grassin-Delyle S, Roquencourt C, Longchampt E, Miguet-Besson I, Glorion M, Salvator H, Devillier P.   +7 more
europepmc   +1 more source

Epigenetic regulation of somatostatin and somatostatin receptors in neuroendocrine tumors and other types of cancer. [PDF]

Rev Endocr Metab Disord, 2021
Klomp MJ, Dalm SU, de Jong M, Feelders RA, Hofland J, Hofland LJ.   +5 more
europepmc   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Theranostic Radiopharmaceuticals of Somatostatin Receptors for Patients with Neuroendocrine Tumors: Agonists Versus Antagonists-A Systematic Review and Meta-Analysis. [PDF]

Int J Mol Sci
Wang Q, Librizzi D, Bagheri S, Ebrahimifard A, Hojjat Shamami A, Rinke A, Eilsberger F, Luster M, Hooshyar Yousefi B.   +8 more
europepmc   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, Volume 117, Issue 10, Page 2619-2635, October 2026.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source