Results 91 to 100 of about 137,964 (298)
Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling [PDF]
The International Journal of Biochemistry & Cell Biology, 2010 Hedgehog (Hh) signalling is mediated through the Patched-1 (Ptch1) receptor. Hh-binding to Ptch1 blocks the inhibitory effects of Ptch1 on the activity of the transmembrane protein, Smoothened (Smo), resulting induction of target genes by the Gli-family of transcription factors. We demonstrate here that Hh-binding to Ptch1 stimulates activation of Erk1/
Michael T. Lewis +4 more
openaire +3 more sources
Developmental Dynamics, EarlyView.Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino +3 more
wiley +1 more source
Genomic factors that shape craniofacial outcome and neural crest vulnerability in FASD
Frontiers in Genetics, 2014 Prenatal alcohol exposure (PAE) causes distinctive facial characteristics in some pregnancies and not others; genetic factors may contribute to this differential vulnerability.
Susan M. Smith +3 more
doaj +1 more source
Developmental Dynamics, EarlyView.Abstract Background Previous experiments inducing leakage of embryonic cerebrospinal fluid (CSF) suggest the necessity of intraventricular CSF pressure (PCSF) for brain morphogenesis. Nevertheless, how embryonic PCSF occurs is unclear, especially in utero. Results Using a Landis water manometer, we measured PCSF in fetal mice isolated from the amniotic
Koichiro Tsujikawa +2 more
wiley +1 more source
Nature Communications, 2017 Ciliary membrane composition is controlled by transition zone (TZ) proteins such as RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse signalling systems like the Sonic hedgehog (Shh) pathway.
K. Schou +12 more
semanticscholar +1 more source
Biochemistry and Biophysics Reports, 2019 Oxysterols are 27-carbon oxidation products of cholesterol metabolism. Oxysterols possess several biological actions, including the promotion of cell death. Here, we examined the ability of 7-ketocholesterol (7-KC), cholestane-3β-5α-6β-triol (triol), and
Debora Levy +7 more
doaj
Developmental Dynamics, EarlyView.Abstract Background Mouse nodal immotile cilia mechanically sense the bending direction for left–right (L–R) determination and activate the left‐side‐specific signaling cascade, leading to increased Nodal activity. Asymmetric distribution of Pkd2, a crucial channel for L–R determination, on immotile cilia has been reported recently. However, the causal
Takanobu A. Katoh +5 more
wiley +1 more source
Genes & Development, 2016 Zhang et al. show that hair follicles’ transit-amplifying cells (HF-TACs) play an essential role in orchestrating dermal adipogenesis through secreting Sonic Hedgehog (SHH).
Bing Zhang +7 more
semanticscholar +1 more source
Ontogenetic expression of Sonic Hedgehog in the chicken subpallium [PDF]
Frontiers in Neuroanatomy, 2010 Sonic hedgehog (SHH) is a secreted signaling factor that is implicated in the molecular patterning of the central nervous system (CNS), somites, and limbs in vertebrates. SHH has a crucial role in the generation of ventral cell types along the entire rostrocaudal axis of the neural tube.
Bardet, Sylvia +3 more
openaire +6 more sources
Sonic Hedgehog Signaling Switches the Mode of Division in the Developing Nervous System
Cell Reports, 2013 The different modes of stem cell division are tightly regulated to balance growth and differentiation during organ development and homeostasis, and these regulatory processes are subverted in tumor formation.
Murielle Saade +6 more
doaj +1 more source